2,4-dichloro-N-isopropyl-N-[2-(isopropylamino)ethyl]benzenesulfonamide
- Product Name
- 2,4-dichloro-N-isopropyl-N-[2-(isopropylamino)ethyl]benzenesulfonamide
- CAS No.
- 946387-07-1
- Chemical Name
- 2,4-dichloro-N-isopropyl-N-[2-(isopropylamino)ethyl]benzenesulfonamide
- Synonyms
- PM-0016;RN 1734;TRPV4 Antagonist I, RN-1734;TRPV4 Antagonist I, RN-1734 - CAS 946387-07-1 - Calbiochem;2,4-dichloro-N-isopropyl-N-[2-(isopropylamino)ethyl]benzenesulfonamide;2,4-dichloro-N-propan-2-yl-N-[2-(propan-2-ylamino)ethyl]benzenesulfonamide;RN-1734 (2,4-Dichloro-N-isopropyl-N-(2-isopropylaminoethyl)benzenesulfonamide);2,4-Dichloro-N-isopropyl-N-(2-isopropylaminoethyl)benzenesulphonamide (RN-1734);2,4-Dichloro-N-(1-methylethyl)-N-[2-[(1-methylethyl)amino]ethyl]benzenesulfonamide;Benzenesulfonamide, 2,4-dichloro-N-(1-methylethyl)-N-[2-[(1-methylethyl)amino]ethyl]-
- CBNumber
- CB11529521
- Molecular Formula
- C14H22Cl2N2O2S
- Formula Weight
- 353.31
- MOL File
- 946387-07-1.mol
2,4-dichloro-N-isopropyl-N-[2-(isopropylamino)ethyl]benzenesulfonamide Property
- storage temp.
- 2-8°C
- solubility
- DMSO: >20mg/mL
- form
- Yellow solid
- color
- white to off-white
Safety
- WGK Germany
- nwg
N-Bromosuccinimide Price
- Product number
- R0658
- Product name
- RN-1734
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $84.1
- Updated
- 2024/03/01
- Product number
- 616520
- Product name
- TRPV4 Antagonist I, RN-1734
- Packaging
- 10mg
- Price
- $111
- Updated
- 2024/03/01
- Product number
- 24205
- Product name
- RN-1734
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $61
- Updated
- 2024/03/01
- Product number
- 24205
- Product name
- RN-1734
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $95
- Updated
- 2024/03/01
- Product number
- R0658
- Product name
- RN-1734
- Purity
- ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $335
- Updated
- 2024/03/01
2,4-dichloro-N-isopropyl-N-[2-(isopropylamino)ethyl]benzenesulfonamide Chemical Properties,Usage,Production
Uses
RN 1734 is a novel TRPV4 modulator.
Uses
RN-1734 has been used as a transient receptor potential vanilloid 4 (TRPV4) blocker to study its effects on differentiation of a corneal epithelial cell model, RCE1(5T5) cells.
General Description
A cell-permeable benzenesulfonamide compound that acts as a selective TRPV4 antagonist and inhibits TRPV4 agonist 4α-PDD- (Cat. No. 524394) stimulated Ca2+ influx (IC50 = 2.3, 3.2 and 5.9 μM, respectively, in HEK293 expressing human, rat, or mouse TRPV4) without affecting the activity of three other human TRP (transient receptor potential) channels, including capsaicin- (Cat. No. 211275) activated TRPV1, camphor-activated TRPV3, and methanol-activated TRPM8 (IC50 >30 μM).
Biological Activity
Selective TRPV4 antagonist (IC 50 values are 2.3, 5.9 and 3.2 μ M for hTRPV4, mTRPV4 and rTRPV4 receptors respectively). Displays selectivity for over other TRP channels (IC 50 values are 2.3, >30, >30 and >100 μ M for TRPV4, TRPV3, TRPM8 and TRPV1 respectively).
Biochem/physiol Actions
RN-1734 is a selective TRPV4 antagonist.
storage
+4°C