ChemicalBook > CAS DataBase List > RKI1447

RKI1447

Product Name
RKI1447
CAS No.
1342278-01-6
Chemical Name
RKI1447
Synonyms
RKI-1447;RKI 1447;CS-855;RKI1447;RKI-1447, >=98%;RKI 1447; RKI1447;RKI1447 USP/EP/BP;7-Pentahydroxyflavone;1-(3-HYDROXYBENZYL)-3-(4-(PYRIDIN-4-YL)THIAZOL-2-YL)UREA;RKI-1447, 98%, a potent small molecule inhibitor of ROCK1 and ROCK2
CBNumber
CB42660015
Molecular Formula
C16H14N4O2S
Formula Weight
326.37
MOL File
1342278-01-6.mol
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RKI1447 Property

Melting point:
>205oC (dec.)
Density 
1.408±0.06 g/cm3(Predicted)
storage temp. 
-20°C Freezer
solubility 
DMSO (Slightly), Methanol (Slightly, Heated)
pka
6.36±0.70(Predicted)
form 
Solid
color 
Pale Yellow to Pale Beige
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
16278
Product name
RKI-1447
Purity
≥98%
Packaging
5mg
Price
$61
Updated
2024/03/01
Cayman Chemical
Product number
16278
Product name
RKI-1447
Purity
≥98%
Packaging
10mg
Price
$109
Updated
2024/03/01
Cayman Chemical
Product number
16278
Product name
RKI-1447
Purity
≥98%
Packaging
50mg
Price
$422
Updated
2024/03/01
TRC
Product number
R550000
Product name
RKI-1447
Packaging
100mg
Price
$875
Updated
2021/12/16
Biorbyt Ltd
Product number
orb181117
Product name
RKI-1447
Purity
>98%
Packaging
250mg
Price
$1356.6
Updated
2021/12/16
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RKI1447 Chemical Properties,Usage,Production

Description

RKI-1447 is an inhibitor of the Rho-associated kinases ROCK1 and 2 (IC50s = 14.5 and 6.2 nM, respectively) that functions by binding to the ATP binding site of the kinase. In cancer cells, RKI-1447 at a concentration of 100 nM has been found to suppress the activation of ROCK substrates myosin light chain (MLC)-2 and the MLC phosphatase PP1 regulatory subunit MYPT1 without effect on the phosphorylation of Akt, MEK, or S6 kinase. Furthermore, it can prevent ROCK-mediated migration, invasion, and anchorage-independent growth of MDA-MB-231 breast cancer cells (IC50 = 709 nM).

Uses

RKI-1447 is a potent and selective ROCK1 and ROCK2 inhibitor with significant anti-invasive and anti-tumor activies.

References

[1] patel r a et al. , rki-1447 is a potent inhibitor of the rho-associated rock kinases with anti-invasive and antitumor activities in breast cancer. cancer res, 2012, 72(19): 5025-5034.

RKI1447 Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from RKI1447 manufacturers

Career Henan Chemical Co
Product
RKI1447 1342278-01-6
Price
US $5.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
1ton
Release date
2019-09-03

1342278-01-6, RKI1447Related Search:

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  • CS-855
  • RKI 1447; RKI1447
  • RKI 1447
  • RKI1447
  • RKI-1447
  • 1-(3-HYDROXYBENZYL)-3-(4-(PYRIDIN-4-YL)THIAZOL-2-YL)UREA
  • Urea, N-[(3-hydroxyphenyl)methyl]-N'-[4-(4-pyridinyl)-2-thiazolyl]-
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  • RKI 1447 1-(3-Hydroxybenzyl)-3-[4-(pyridin-4-yl)thiazol-2-yl]urea
  • RKI-1447, >=98%
  • RKI-1447, 98%, a potent small molecule inhibitor of ROCK1 and ROCK2
  • 1-[(3-hydroxyphenyl)methyl]-3-(4-pyridin-4-yl-1,3-thiazol-2-yl)urea
  • RKI1447 USP/EP/BP
  • 7-Pentahydroxyflavone
  • 1342278-01-6
  • Inhibitors