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MACULOSIN

Product Name
MACULOSIN
CAS No.
4549-02-4
Chemical Name
MACULOSIN
Synonyms
A-19C;0/4/49;ML-1532II;MACULOSIN;Maculosin TFA;CYCLO(-PRO-TYR);Antibiotic A-19C;cyclo(L-Pro-L-Tyr);Cyclo(L-Tyr-L-Pro-);MACULOSIN USP/EP/BP
CBNumber
CB0265753
Molecular Formula
C14H16N2O3
Formula Weight
260.29
MOL File
4549-02-4.mol
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MACULOSIN Property

Melting point:
156-159 °C
Boiling point:
581.4±43.0 °C(Predicted)
Density 
1.36±0.1 g/cm3(Predicted)
storage temp. 
-15°C
solubility 
DMF: soluble; DMSO: soluble; Ethanol: soluble; Methanol: soluble
form 
A solid
pka
9.92±0.15(Predicted)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

H311Toxic in contact with skin

H331Toxic if inhaled

H371May cause damage to organs

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P309+P311IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.

P311Call a POISON CENTER or doctor/physician.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P322Specific measures (see …on this label).

P330Rinse mouth.

P361Remove/Take off immediately all contaminated clothing.

P363Wash contaminated clothing before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical
Product number
25019
Product name
Maculosin
Purity
≥95%
Packaging
5mg
Price
$130
Updated
2024/03/01
Cayman Chemical
Product number
25019
Product name
Maculosin
Purity
≥95%
Packaging
25mg
Price
$416
Updated
2024/03/01
TRC
Product number
C988385
Product name
Cyclo(L-prolinyl-L-tyrosine)
Packaging
25mg
Price
$385
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC108323
Product name
Cyclo(-Pro-Tyr)
Packaging
500mg
Price
$155
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC108323
Product name
Cyclo(-Pro-Tyr)
Packaging
1g
Price
$273
Updated
2021/12/16
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MACULOSIN Chemical Properties,Usage,Production

Description

Maculosin is a diketopiperazine metabolite produced by A. alternata, L. capsici, Streptomyces, and the Gram-negative, nonobligate predator bacterial strain 679-2. It acts as a host-specific phytotoxin, inducing formation of weeping necrotic lesions in leaves of spotted knapweed (C. maculosa) when used at a concentration of 10 μM. Maculosin reduces the growth of the plant pathogenic bacteria X. axonopodis and R. solanacearum (MICs = 31.25 μg/ml) as well as the pathogenic oomycetes P. cactorum, P. capsici, P. cinnamomi, P. infestans, and P. ultimum when used at concentrations ranging from 10 to 100 mg/ml. Maculosin also inhibits the growth of M. luteus, M. smegmatis, S. cerevisiae, C. albicans, C. neoformans, and A. niger when used in combination with pyrrolnitrin or banegasin.

Uses

Cyclo(L-prolinyl-L-tyrosine) is a diketopiperazine derivative isolated from Bacillus thuringiensis and Bacillus endophyticus.

Uses

Cyclo(L-Pro-L-Tyr) (maculosin) is a diketopiperazine formed by the fusion of tyrosine and proline, reported as a secondary metabolite of fungi and bacteria. In Pseudomonas aeruginosa, cyclo(L-Pro-L-Tyr) is capable of activating N-acylhomoserine lactones (AHLs). Cyclo(L-Pro-L-Tyr) is also capable of activating or antagonizing other LuxR-based quorum-sensing systems. While the mode of action of cyclo(L-Pro-L-Tyr) is not known, its activity suggests the existence of cross talk among bacterial signalling systems. Cyclo(L-Pro-L-Tyr) was identified as a host-specific toxin produced by Alternaria alternata on spotted knapweed.

Definition

ChEBI: A homodetic cyclic peptide that is a dipeptide composed of L-proline and L-tyrosine joined by peptide linkages.

MACULOSIN Preparation Products And Raw materials

Raw materials

Preparation Products

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MACULOSIN Suppliers

GL Biochem (Shanghai) Ltd
Tel
21-61263452 13641803416
Fax
86-21-61263399
Email
ymbetter@glbiochem.com
Country
China
ProdList
9981
Advantage
64
Chemsky (shanghai) International Co.,Ltd
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
15421
Advantage
60
Sichuan Wei Keqi Biological Technology Co., Ltd.
Tel
028-81700200 18116577057
Fax
028-81705658
Email
3003855609@qq.com
Country
China
ProdList
7892
Advantage
56
Nanjing Leon Biological Technology Co., Ltd.
Tel
17705183659
Fax
84523390
Email
sales@njleonbiotech.com
Country
China
ProdList
5504
Advantage
55
Lynnchem
Tel
86-(0)29-85992781 17792393971
Email
info@lynnchem.com
Country
China
ProdList
4587
Advantage
58
Nanjing Peptide Biotech Ltd.
Tel
025-58361106-805 13082558573
Fax
025-58361106-806
Email
liugang@njpeptide.com
Country
China
ProdList
9961
Advantage
55
Novachemistry
Tel
44-20819178-90 02081917890
Fax
(0)2080432064
Email
info@novachemistry.com
Country
United Kingdom
ProdList
4381
Advantage
58
Hangzhou Peptidego Biotech Co.,Ltd.
Tel
0571-87213919
Fax
0571-87213919
Email
eric@peptidego.com
Country
China
ProdList
6119
Advantage
58
Shenzhen Polymeri Biochemical Technology Co., Ltd.
Tel
+86-400-002-6226 13028896684
Email
sales@rrkchem.com
Country
China
ProdList
55717
Advantage
58
BOC Sciences
Tel
+16314854226
Email
inquiry@bocsci.com
Country
United States
ProdList
19743
Advantage
58
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View Lastest Price from MACULOSIN manufacturers

Zhejiang J&C Biological Technology Co.,Limited
Product
MACULOSIN 4549-02-4
Price
US $0.00/gram
Min. Order
1gram
Purity
99%
Supply Ability
10kg
Release date
2022-02-17

4549-02-4, MACULOSINRelated Search:


  • MACULOSIN
  • CYCLO(-PRO-TYR)
  • A-19C
  • Antibiotic A-19C
  • Antibiotic ML-1532II
  • Cyclo(L-Tyr-L-Pro-)
  • ML-1532II
  • (3S,8aS)-3-(4-hydroxybenzyl)-2,3,6,7,8,8a-hexahydropyrrolo[1,2-a]pyrazine-1,4-quinone
  • (3S,8aS)-3-[(4-hydroxyphenyl)methyl]-2,3,6,7,8,8a-hexahydropyrrolo[1,2-a]pyrazine-1,4-dione
  • cyclo(L-Pro-L-Tyr)
  • (3S,8aS)-Hexahydro-3-[(4-hydroxyphenyl)methyl]pyrrolo[1,2-a]pyrazine-1,4-dione
  • Cyclo(L-prolinyl-L-tyrosine)
  • Pyrrolo[1,2-a]pyrazine-1,4-dione, hexahydro-3-[(4-hydroxyphenyl)methyl]-, (3S,8aS)-
  • MACULOSIN USP/EP/BP
  • cyclo(L-Pro-L-Tyr),Maculosin
  • inhibit,Cyclo(Tyr-Pro),Alternaria alternata,anti-cancer,liver cancer,non-toxicity,967564,Inhibitor,cyclo(L Pro L Tyr),antioxidant,spotted knapweed,cyclo(LProLTyr),Maculosin
  • 0/4/49
  • Maculosin TFA
  • 4549-02-4
  • Cell Signaling and Neuroscience
  • Cell Biology
  • BioChemical
  • Gene Regulation and Expression
  • Reagents
  • Tools for Gene Regulation Research