MACULOSIN

Product Name: MACULOSIN
CAS No.: 4549-02-4
Chemical Name: MACULOSIN
Synonyms: A-19C;0/4/49;ML-1532II;MACULOSIN;Maculosin TFA;CYCLO(-PRO-TYR);Antibiotic A-19C;cyclo(L-Pro-L-Tyr);Cyclo(L-Tyr-L-Pro-);MACULOSIN USP/EP/BP
CBNumber: CB0265753
Molecular Formula: C14H16N2O3
Formula Weight: 260.29
MOL File: 4549-02-4.mol

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MACULOSIN Property

Melting point:: 156-159 °C
Boiling point:: 581.4±43.0 °C(Predicted)
Density: 1.36±0.1 g/cm3(Predicted)
storage temp.: -15°C
solubility: DMF: soluble; DMSO: soluble; Ethanol: soluble; Methanol: soluble
form: A solid
pka: 9.92±0.15(Predicted)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H311Toxic in contact with skin

H331Toxic if inhaled

H371May cause damage to organs

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P309+P311IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.

P311Call a POISON CENTER or doctor/physician.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P322Specific measures (see …on this label).

P330Rinse mouth.

P361Remove/Take off immediately all contaminated clothing.

P363Wash contaminated clothing before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 25019
Product name: Maculosin
Purity: ≥95%
Packaging: 5mg
Price: $130
Updated: 2024/03/01

Cayman Chemical

Product number: 25019
Product name: Maculosin
Purity: ≥95%
Packaging: 25mg
Price: $416
Updated: 2024/03/01

TRC

Product number: C988385
Product name: Cyclo(L-prolinyl-L-tyrosine)
Packaging: 25mg
Price: $385
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC108323
Product name: Cyclo(-Pro-Tyr)
Packaging: 500mg
Price: $155
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC108323
Product name: Cyclo(-Pro-Tyr)
Packaging: 1g
Price: $273
Updated: 2021/12/16

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MACULOSIN Chemical Properties,Usage,Production

Description

Maculosin is a diketopiperazine metabolite produced by A. alternata, L. capsici, Streptomyces, and the Gram-negative, nonobligate predator bacterial strain 679-2. It acts as a host-specific phytotoxin, inducing formation of weeping necrotic lesions in leaves of spotted knapweed (C. maculosa) when used at a concentration of 10 μM. Maculosin reduces the growth of the plant pathogenic bacteria X. axonopodis and R. solanacearum (MICs = 31.25 μg/ml) as well as the pathogenic oomycetes P. cactorum, P. capsici, P. cinnamomi, P. infestans, and P. ultimum when used at concentrations ranging from 10 to 100 mg/ml. Maculosin also inhibits the growth of M. luteus, M. smegmatis, S. cerevisiae, C. albicans, C. neoformans, and A. niger when used in combination with pyrrolnitrin or banegasin.

Uses

Cyclo(L-prolinyl-L-tyrosine) is a diketopiperazine derivative isolated from Bacillus thuringiensis and Bacillus endophyticus.

Uses

Cyclo(L-Pro-L-Tyr) (maculosin) is a diketopiperazine formed by the fusion of tyrosine and proline, reported as a secondary metabolite of fungi and bacteria. In Pseudomonas aeruginosa, cyclo(L-Pro-L-Tyr) is capable of activating N-acylhomoserine lactones (AHLs). Cyclo(L-Pro-L-Tyr) is also capable of activating or antagonizing other LuxR-based quorum-sensing systems. While the mode of action of cyclo(L-Pro-L-Tyr) is not known, its activity suggests the existence of cross talk among bacterial signalling systems. Cyclo(L-Pro-L-Tyr) was identified as a host-specific toxin produced by Alternaria alternata on spotted knapweed.

Definition

ChEBI: A homodetic cyclic peptide that is a dipeptide composed of L-proline and L-tyrosine joined by peptide linkages.

MACULOSIN Preparation Products And Raw materials

Raw materials

Preparation Products

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MACULOSIN Suppliers

China 35 Switzerland 1 United Kingdom 2 United States 6 Global 44

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View Lastest Price from MACULOSIN manufacturers

Zhejiang J&C Biological Technology Co.,Limited

Product: MACULOSIN 4549-02-4
Price: US $0.00/gram
Min. Order: 1gram
Purity: 99%
Supply Ability: 10kg
Release date: 2022-02-17

4549-02-4, MACULOSINRelated Search:

CYCLO(-PRO-VAL) 1-[[4-[(4-Fluoro-2-methyl-1H-indol-5-yl)oxy]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]oxy]-2-propanol Cyclo(-Phe-Tyr) CYCLO(-MET-PRO) cyclo(Pro-Ser) cyclo(Pro-Asp) cyclo(Pro-Glu) CYCLO(-PHE-PRO) cyclo(Pro-Lys) cyclo(Pro-Asn) cyclo(Pro-Gln) cyclo(Pro-Cys) MACULOSIN CYCLO(-GLY-PHE) (S,S)-3-BENZYL-1,4-DIAZABICYCLO[4.3.0]NONANE (3S)-3-((4-HYDROXYPHENYL)METHYL)-2,5-PIPERAZINEDIONE (R)-HEXAHYDROPYRROLO[1,2-A]PYRAZIN-1(2H)-ONE CYCLO(-GLY-PRO)

MACULOSIN

CYCLO(-PRO-TYR)

A-19C

Antibiotic A-19C

Antibiotic ML-1532II

Cyclo(L-Tyr-L-Pro-)

ML-1532II

(3S,8aS)-3-(4-hydroxybenzyl)-2,3,6,7,8,8a-hexahydropyrrolo[1,2-a]pyrazine-1,4-quinone

(3S,8aS)-3-[(4-hydroxyphenyl)methyl]-2,3,6,7,8,8a-hexahydropyrrolo[1,2-a]pyrazine-1,4-dione

cyclo(L-Pro-L-Tyr)

(3S,8aS)-Hexahydro-3-[(4-hydroxyphenyl)methyl]pyrrolo[1,2-a]pyrazine-1,4-dione

Cyclo(L-prolinyl-L-tyrosine)

Pyrrolo[1,2-a]pyrazine-1,4-dione, hexahydro-3-[(4-hydroxyphenyl)methyl]-, (3S,8aS)-

MACULOSIN USP/EP/BP

cyclo(L-Pro-L-Tyr),Maculosin

inhibit,Cyclo(Tyr-Pro),Alternaria alternata,anti-cancer,liver cancer,non-toxicity,967564,Inhibitor,cyclo(L Pro L Tyr),antioxidant,spotted knapweed,cyclo(LProLTyr),Maculosin

0/4/49

Maculosin TFA

4549-02-4

Cell Signaling and Neuroscience

Cell Biology

BioChemical

Gene Regulation and Expression

Reagents

Tools for Gene Regulation Research