ChemicalBook > CAS DataBase List > CYCLO(-PRO-VAL)

CYCLO(-PRO-VAL)

Product Name
CYCLO(-PRO-VAL)
CAS No.
2854-40-2
Chemical Name
CYCLO(-PRO-VAL)
Synonyms
Cyclo(Val-Pro);CYCLO(-PRO-VAL);Cyclo(L-Val-L-Pro-);Cyclo(L-Pro-L-Val-);2854-40-2/5654-87-5;Cyclo(L-prolyl-L-valyl);CYCLO(L-PROLYL-L-VALINE);Cyclo(L-Pro-L-Val),CYCLO(-PRO-VAL);(3S,8aS)-3-Isopropylhexahydropyrrolo[1,2-a]pyrazine-1,4-dione;(3S,8aα)-3β-Isopropyloctahydropyrrolo[1,2-a]pyrazine-1,4-dione
CBNumber
CB0132749
Molecular Formula
C10H16N2O2
Formula Weight
196.25
MOL File
2854-40-2.mol
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CYCLO(-PRO-VAL) Property

Melting point:
190-192 °C
Boiling point:
420.7±34.0 °C(Predicted)
Density 
1.17±0.1 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
solubility 
Chloroform (Slightly, Sonicated), Methanol (Slightly)
form 
Solid
pka
13.15±0.40(Predicted)
color 
White to Off-White
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
27961
Product name
Cyclo(L-Pro-L-Val)
Packaging
25mg
Price
$37
Updated
2024/03/01
Cayman Chemical
Product number
27961
Product name
Cyclo(L-Pro-L-Val)
Packaging
50mg
Price
$68
Updated
2024/03/01
Cayman Chemical
Product number
27961
Product name
Cyclo(L-Pro-L-Val)
Packaging
100mg
Price
$129
Updated
2024/03/01
Cayman Chemical
Product number
27961
Product name
Cyclo(L-Pro-L-Val)
Packaging
250mg
Price
$283
Updated
2024/03/01
TRC
Product number
C989825
Product name
Cyclo(L-prolyl-L-valyl)
Packaging
25mg
Price
$335
Updated
2021/12/16
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CYCLO(-PRO-VAL) Chemical Properties,Usage,Production

Description

Cyclo(L-Pro-L-Val) is a diketopiperazine that has been found in the marine sponge T. ignis, the bacterium B. pumilus, and the fungus A. fumigatus, among others. It is active against the bacteria S. aureus and B. subtilis (MICs = 16.3 and 18.2 μg/ml, respectively) but not E. coli (MIC = >20 μg/ml). Cyclo(L-Pro-L-Val) inhibits activation of a LuxR-dependent E. coli biosensor by the quorum-sensing molecule 3-oxo-hexanoyl-homoserine lactone (IC50 = 0.4 mM) and activates violacein pigment production in the LuxR-dependent C. violaceum acyl homoserine lactone reporter strain CV026. However, it does not activate or inhibit lacZ-based reporter fusions in S. liquefaciens or A. tumefaciens.

Uses

Cyclo(L-Pro-L-Val) is a diketopiperazine formed by the fusion of valine and proline, reported as a secondary metabolite of fungi and bacteria. In Pseudomonas aeruginosa, cyclo(L-Pro-L-Val) is capable of activating N-acylhomoserine lactones (AHLs). Cyclo(L-Pro-L-Val) is also capable of activating or antagonizing other LuxR-based quorum-sensing systems. While the mode of action of the cyclo(L-Pro-L-Val) is not known, its activity suggests the existence of cross talk among bacterial signalling systems.

Uses

Cyclo(L-prolyl-L-valyl) is a metabolite found in various marine fungi and bacteria. It is a diketopiperazine derivative isolated from Bacillus thuringiensis and Bacillus endophyticus.

Definition

ChEBI: Cyclo(L-Pro-L-Val) is a piperazinone. It has a role as a metabolite.

CYCLO(-PRO-VAL) Preparation Products And Raw materials

Raw materials

Preparation Products

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CYCLO(-PRO-VAL) Suppliers

CHINA 58 India 1 United Kingdom 2 United States 4 Global 65
GL Biochem (Shanghai) Ltd
Tel
21-61263452 13641803416
Fax
86-21-61263399
Email
ymbetter@glbiochem.com
Country
China
ProdList
9981
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64
Chemsky (shanghai) International Co.,Ltd
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
15421
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60
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.
Tel
025-66099280 17798518460
Fax
(1)02557626880
Email
cfzhang@aikonchem.com
Country
China
ProdList
19918
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55
Avantpbc Chemical Tech(Shanghai) Co,Ltd.
Tel
17802107445
Country
China
ProdList
185
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55
Nanjing Leon Biological Technology Co., Ltd.
Tel
17705183659
Fax
84523390
Email
sales@njleonbiotech.com
Country
China
ProdList
5503
Advantage
55
Lynnchem
Tel
86-(0)29-85992781 17792393971
Email
info@lynnchem.com
Country
China
ProdList
4587
Advantage
58
Nanjing Peptide Biotech Ltd.
Tel
025-58361106-805 13082558573
Fax
025-58361106-806
Email
liugang@njpeptide.com
Country
China
ProdList
9961
Advantage
55
Novachemistry
Tel
44-20819178-90 02081917890
Fax
(0)2080432064
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info@novachemistry.com
Country
United Kingdom
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4381
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58
Hangzhou Peptidego Biotech Co.,Ltd.
Tel
0571-87213919
Fax
0571-87213919
Email
eric@peptidego.com
Country
China
ProdList
6347
Advantage
58
Shanghai Hongye Biotechnology Co. Ltd
Tel
400-9205774
Email
sales@glpbio.cn
Country
China
ProdList
6870
Advantage
58

2854-40-2, CYCLO(-PRO-VAL)Related Search:

CYCLO(-PHE-PRO) MACULOSIN Cyclo(-Phe-Tyr) CYCLO(-MET-PRO) cyclo(Pro-Ser) cyclo(Pro-Asp) cyclo(Pro-Glu) cyclo(Pro-Lys) cyclo(Pro-Asn) cyclo(Pro-Gln) cyclo(Pro-Cys) (S)-3-Isopropyl-2,5-piperazinedione CYCLO(-PRO-VAL) 3-ISOPROPYL-PIPERAZIN-2-ONE (R)-HEXAHYDROPYRROLO[1,2-A]PYRAZIN-1(2H)-ONE (3S)-3-ISOPROPYL-1-METHYLPIPERAZINE (2S)-ISOPROPYLPIPERAZINE

  • CYCLO(-PRO-VAL)
  • (3S,8aS)-3-Isopropyl-6,7,8,8aα-tetrahydropyrrolo[1,2-a]pyrazine-1,4(2H,3H)-dione
  • (3S,8aS)-3β-Isopropyl-6,7,8,8a-tetrahydropyrrolo[1,2-a]pyrazine-1,4(2H,3H)-dione
  • (3S,8aS)-Octahydro-3-(1-methylethyl)pyrrolo[1,2-a]pyrazine-1,4-dione
  • (3S,8aα)-3β-Isopropyloctahydropyrrolo[1,2-a]pyrazine-1,4-dione
  • Cyclo(L-Pro-L-Val-)
  • Cyclo(L-Val-L-Pro-)
  • Pyrrolo[1,2-a]pyrazine-1,4-dione, hexahydro-3-(1-methylethyl)-, (3S,8aS)-
  • (3S,8aS)-3-propan-2-yl-2,3,6,7,8,8a-hexahydropyrrolo[1,2-a]pyrazine-1,4-dione
  • Cyclo(L-prolyl-L-valyl)
  • CYCLO(L-PROLYL-L-VALINE)
  • (3S,8aS)-3-(propan-2-yl)-octahydropyrrolo[1,2-a]p yrazine-1,4-dione
  • (3S,8aS)-3-Isopropylhexahydropyrrolo[1,2-a]pyrazine-1,4-dione
  • Cyclo(L-Pro-L-Val),CYCLO(-PRO-VAL)
  • 2854-40-2/5654-87-5
  • Cyclo(Val-Pro)
  • 2854-40-2