CYCLO(-PRO-VAL)
- Product Name
- CYCLO(-PRO-VAL)
- CAS No.
- 2854-40-2
- Chemical Name
- CYCLO(-PRO-VAL)
- Synonyms
- Cyclo(Val-Pro);CYCLO(-PRO-VAL);Cyclo(L-Val-L-Pro-);Cyclo(L-Pro-L-Val-);2854-40-2/5654-87-5;Cyclo(L-prolyl-L-valyl);CYCLO(L-PROLYL-L-VALINE);Cyclo(L-Pro-L-Val),CYCLO(-PRO-VAL);(3S,8aS)-3-Isopropylhexahydropyrrolo[1,2-a]pyrazine-1,4-dione;(3S,8aα)-3β-Isopropyloctahydropyrrolo[1,2-a]pyrazine-1,4-dione
- CBNumber
- CB0132749
- Molecular Formula
- C10H16N2O2
- Formula Weight
- 196.25
- MOL File
- 2854-40-2.mol
CYCLO(-PRO-VAL) Property
- Melting point:
- 190-192 °C
- Boiling point:
- 420.7±34.0 °C(Predicted)
- Density
- 1.17±0.1 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- Chloroform (Slightly, Sonicated), Methanol (Slightly)
- form
- Solid
- pka
- 13.15±0.40(Predicted)
- color
- White to Off-White
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 27961
- Product name
- Cyclo(L-Pro-L-Val)
- Packaging
- 25mg
- Price
- $37
- Updated
- 2024/03/01
- Product number
- 27961
- Product name
- Cyclo(L-Pro-L-Val)
- Packaging
- 50mg
- Price
- $68
- Updated
- 2024/03/01
- Product number
- 27961
- Product name
- Cyclo(L-Pro-L-Val)
- Packaging
- 100mg
- Price
- $129
- Updated
- 2024/03/01
- Product number
- 27961
- Product name
- Cyclo(L-Pro-L-Val)
- Packaging
- 250mg
- Price
- $283
- Updated
- 2024/03/01
- Product number
- C989825
- Product name
- Cyclo(L-prolyl-L-valyl)
- Packaging
- 25mg
- Price
- $335
- Updated
- 2021/12/16
CYCLO(-PRO-VAL) Chemical Properties,Usage,Production
Description
Cyclo(L-Pro-L-Val) is a diketopiperazine that has been found in the marine sponge T. ignis, the bacterium B. pumilus, and the fungus A. fumigatus, among others. It is active against the bacteria S. aureus and B. subtilis (MICs = 16.3 and 18.2 μg/ml, respectively) but not E. coli (MIC = >20 μg/ml). Cyclo(L-Pro-L-Val) inhibits activation of a LuxR-dependent E. coli biosensor by the quorum-sensing molecule 3-oxo-hexanoyl-homoserine lactone (IC50 = 0.4 mM) and activates violacein pigment production in the LuxR-dependent C. violaceum acyl homoserine lactone reporter strain CV026. However, it does not activate or inhibit lacZ-based reporter fusions in S. liquefaciens or A. tumefaciens.
Uses
Cyclo(L-Pro-L-Val) is a diketopiperazine formed by the fusion of valine and proline, reported as a secondary metabolite of fungi and bacteria. In Pseudomonas aeruginosa, cyclo(L-Pro-L-Val) is capable of activating N-acylhomoserine lactones (AHLs). Cyclo(L-Pro-L-Val) is also capable of activating or antagonizing other LuxR-based quorum-sensing systems. While the mode of action of the cyclo(L-Pro-L-Val) is not known, its activity suggests the existence of cross talk among bacterial signalling systems.
Uses
Cyclo(L-prolyl-L-valyl) is a metabolite found in various marine fungi and bacteria. It is a diketopiperazine derivative isolated from Bacillus thuringiensis and Bacillus endophyticus.
Definition
ChEBI: Cyclo(L-Pro-L-Val) is a piperazinone. It has a role as a metabolite.