ChemicalBook > CAS DataBase List > CYCLO(-PRO-VAL)

CYCLO(-PRO-VAL)

Product Name: CYCLO(-PRO-VAL)
CAS No.: 2854-40-2
Chemical Name: CYCLO(-PRO-VAL)
Synonyms: c(Pro-Val);Cyclo(Val-Pro);CYCLO(-PRO-VAL);Cyclo(L-Val-L-Pro-);Cyclo(L-Pro-L-Val-);2854-40-2/5654-87-5;Cyclo(L-prolyl-L-valyl);CYCLO(L-PROLYL-L-VALINE);Vildagliptin Impurity 114;Cyclo(L-Pro-L-Val),CYCLO(-PRO-VAL)
CBNumber: CB0132749
Molecular Formula: C10H16N2O2
Formula Weight: 196.25
MOL File: 2854-40-2.mol

Less

CYCLO(-PRO-VAL) Property

Melting point:: 190-192 °C
Boiling point:: 420.7±34.0 °C(Predicted)
Density: 1.17±0.1 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
solubility: Chloroform (Slightly, Sonicated), Methanol (Slightly)
form: Solid
pka: 13.15±0.40(Predicted)
color: White to Off-White
Sequence: Cyclo(Pro-Val)

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Less

N-Bromosuccinimide Price

TCI Chemical

Product number: C3893
Product name: Cyclo(L-Pro-L-Val)
Purity: min. 95.0 %
Packaging: 25MG
Price: $73
Updated: 2025/07/31

Cayman Chemical

Product number: 27961
Product name: Cyclo(L-Pro-L-Val)
Packaging: 25mg
Price: $37
Updated: 2024/03/01

Cayman Chemical

Product number: 27961
Product name: Cyclo(L-Pro-L-Val)
Packaging: 50mg
Price: $68
Updated: 2024/03/01

Cayman Chemical

Product number: 27961
Product name: Cyclo(L-Pro-L-Val)
Packaging: 100mg
Price: $129
Updated: 2024/03/01

Cayman Chemical

Product number: 27961
Product name: Cyclo(L-Pro-L-Val)
Packaging: 250mg
Price: $283
Updated: 2024/03/01

Less

CYCLO(-PRO-VAL) Chemical Properties,Usage,Production

Description

Cyclo(L-Pro-L-Val) is a diketopiperazine that has been found in the marine sponge T. ignis, the bacterium B. pumilus, and the fungus A. fumigatus, among others. It is active against the bacteria S. aureus and B. subtilis (MICs = 16.3 and 18.2 μg/ml, respectively) but not E. coli (MIC = >20 μg/ml). Cyclo(L-Pro-L-Val) inhibits activation of a LuxR-dependent E. coli biosensor by the quorum-sensing molecule 3-oxo-hexanoyl-homoserine lactone (IC₅₀ = 0.4 mM) and activates violacein pigment production in the LuxR-dependent C. violaceum acyl homoserine lactone reporter strain CV026. However, it does not activate or inhibit lacZ-based reporter fusions in S. liquefaciens or A. tumefaciens.

Uses

Cyclo(L-Pro-L-Val) is a diketopiperazine formed by the fusion of valine and proline, reported as a secondary metabolite of fungi and bacteria. In Pseudomonas aeruginosa, cyclo(L-Pro-L-Val) is capable of activating N-acylhomoserine lactones (AHLs). Cyclo(L-Pro-L-Val) is also capable of activating or antagonizing other LuxR-based quorum-sensing systems. While the mode of action of the cyclo(L-Pro-L-Val) is not known, its activity suggests the existence of cross talk among bacterial signalling systems.

Uses

Cyclo(L-prolyl-L-valyl) is a metabolite found in various marine fungi and bacteria. It is a diketopiperazine derivative isolated from Bacillus thuringiensis and Bacillus endophyticus.

Definition

ChEBI: Cyclo(L-Pro-L-Val) is a piperazinone. It has a role as a metabolite.

References

[1] FRANCIS J. SCHMIDTZ. Metabolites from the marine sponge Tedania ignis. A new atisanediol and several known diketopiperazines[J]. The Journal of Organic Chemistry, 1983, 48 22: 3941-3945. DOI: 10.1021/jo00170a011
[2] CHRISTIANE BRACK Frieder S Annett Mikolasch. 2,5-Diketopiperazines Produced by Bacillus pumilus During Bacteriolysis of Arthrobacter citreus[J]. Marine Biotechnology, 2014, 16 4: 385-395. DOI: 10.1007/s10126-014-9559-y
[3] BAHAA EL-DIEN M. EL-GENDY Mostafa E R. Antibacterial activity of diketopiperazines isolated from a marine fungus using t-butoxycarbonyl group as a simple tool for purification[J]. Bioorganic & Medicinal Chemistry Letters, 2015, 25 16: Pages 3125-3128. DOI: 10.1016/j.bmcl.2015.06.010
[4] M T HOLDEN. Quorum-sensing cross talk: isolation and chemical characterization of cyclic dipeptides from Pseudomonas aeruginosa and other gram-negative bacteria.[J]. Molecular Microbiology, 1999, 33 6: 1254-1266. DOI: 10.1046/j.1365-2958.1999.01577.x

CYCLO(-PRO-VAL) Preparation Products And Raw materials

Raw materials

Preparation Products

Less

CYCLO(-PRO-VAL) Suppliers

CHINA 86 India 1 United Kingdom 2 United States 6 Global 95

GL Biochem (Shanghai) Ltd

Tel: 21-61263452 13641803416
Fax: 86-21-61263399
Email: ymbetter@glbiochem.com
Country: China
ProdList: 9981
Advantage: 64

Chemsky (shanghai) International Co.,Ltd

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 15402
Advantage: 60

Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.

Tel: 025-66113011 17798518460
Fax: (1)02557626880
Email: cfzhang@aikonchem.com
Country: China
ProdList: 19913
Advantage: 55

Wuhan ChemFaces Biochemical Co., Ltd.

Tel: 18607101326 15172504745
Fax: +86-27-84254680
Email: aileen@chemfaces.com
Country: China
ProdList: 6905
Advantage: 55

Avantpbc Chemical Tech(Shanghai) Co,Ltd.

Tel: 17802107445
Country: China
ProdList: 185
Advantage: 55

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
Advantage: 60

Nanjing Leon Biological Technology Co., Ltd.

Tel: 17705183659
Fax: 84523390
Email: sales@njleonbiotech.com
Country: China
ProdList: 5501
Advantage: 55

Lynnchem

Tel: 86-(0)29-85992781 17792393971
Email: info@lynnchem.com
Country: China
ProdList: 4587
Advantage: 58

Nanjing Peptide Biotech Ltd.

Tel: 025-58361106-805 15951641583
Fax: 025-58361106-806
Email: zhao.xu@njpeptide.com
Country: China
ProdList: 9979
Advantage: 55

Hangzhou Peptidego Biotech Co.,Ltd.

Tel: 0571-87213919
Email: Eric@peptidego.com
Country: China
ProdList: 7408
Advantage: 58

Shanghai Hongye Biotechnology Co. Ltd

Tel: 400-9205774
Email: sales@glpbio.cn
Country: China
ProdList: 6777
Advantage: 58

Nanjing Digger Medical Technology Co. Ltd.

Tel: 025-025-51191215 18013836722
Fax: 025-51191215
Email: 2399235533@qq.com
Country: China
ProdList: 4933
Advantage: 58

Shenzhen Polymeri Biochemical Technology Co., Ltd.

Tel: +86-400-002-6226 +86-13028896684;
Email: sales@rrkchem.com
Country: China
ProdList: 57422
Advantage: 58

Zhejiang J&C Biological Technology Co.,Limited

Tel: +1-2135480471
Email: sales@sarms4muscle.com
Country: China
ProdList: 10473
Advantage: 58

Nextpeptide Inc

Tel: +86-0571-81612335 +8613336028439
Email: sales@nextpeptide.com
Country: China
ProdList: 19908
Advantage: 58

Shaanxi Xinyan Bomei Biotechnology Co., Ltd.

Tel: 13892832556
Email: 2440688701@qq.com
Country: China
ProdList: 1994
Advantage: 58

Jiangsu Hongmin Pharmaceutical Co., Ltd.

Tel: 18221292452
Email: fannieliu@glschina.com
Country: China
ProdList: 6798
Advantage: 58

ChemeGen(Shanghai) Biotechnology Co.,Ltd.

Tel: 18818260767
Fax: QQ 3610331285
Email: sales@chemegen.com
Country: China
ProdList: 11218
Advantage: 58

Nanjing chengqimei Biotechnology Co., Ltd

Tel: 19850819832
Email: 2173594524@qq.com
Country: China
ProdList: 2638
Advantage: 58

BioBioPha Co., Ltd.

Tel: 0871-65217109
Fax: 0871-65215563
Email: y.liu@mail.biobiopha.com
Country: China
ProdList: 1388
Advantage: 58

Nanchang Tianzhen Biotechnology Co., Ltd

Tel: 13758194781 13173652190
Email: 522013271@qq.com
Country: China
ProdList: 2395
Advantage: 58

Shanghai Binsui Biotechnology Co., Ltd.

Tel: 18301908279
Fax: 021-54387656
Email: 1292752157@qq.com
Country: China
ProdList: 7683
Advantage: 58

Wuxi Helen Biotechnology Co., Ltd.,

Tel: 0510-85629785 18013409632
Fax: 0510-85625359
Email: sales@reading-chemicals.com
Country: China
ProdList: 14081
Advantage: 58

Meng Cheng Technology (Shanghai) Co., LTD

Tel: 400-820-6829
Email: sales@mitachieve.com
Country: China
ProdList: 8860
Advantage: 58

Hangzhou Go Top Peptide Biotech

Tel: 15397062932
Email: sales1@gotopbio.com
Country: China
ProdList: 2923
Advantage: 58

Energy Chemical

Tel: 021-58432009 400-005-6266
Fax: 021-58436166
Email: marketing@energy-chemical.com
Country: China
ProdList: 44918
Advantage: 58

Nanjing Shizhou Biology Technology Co.,Ltd

Tel: 13675144456
Fax: 025-85563444
Email: sean.lv@synzest.com
Country: China
ProdList: 10784
Advantage: 58

cjbscvictory

Tel: 13348960310
Email: 3003867561@qq.com
Country: China
ProdList: 10503
Advantage: 58

TCI (Shanghai) Chemical Trading Co., Ltd.

Tel: 021-61109150
Fax: 021-61105897
Email: sales@tcisct.com
Country: China
ProdList: 29668
Advantage: 58

Bide Pharmatech Ltd.

Tel: 400-1647117 13681763483
Email: product02@bidepharm.com
Country: China
ProdList: 59936
Advantage: 58

Shanghai Moqi Biological Technology Co., LTD

Tel: 021-38218169 13681877033
Email: 2702713455@qq.com
Country: China
ProdList: 9997
Advantage: 58

Shaoxing Junyu Biotechnology Co., LTD

Tel: 0571-0571-88211921 19105816207
Email: sales4@gotopbio.com
Country: China
ProdList: 5144
Advantage: 58

TargetMol Chemicals Inc.

Tel: 4008200310
Email: marketing@tsbiochem.com
Country: China
ProdList: 24961
Advantage: 58

Hangzhou Sinoda Pharmaceutical Technology Co. LTD

Tel: 0571-87213919 17306812703
Email: 3007955328@qq.com
Country: China
ProdList: 6979
Advantage: 58

Shanghai Maclean Biochemical Technology Co., LTD

Tel: 021-021-50706066 15221275939
Email: shenlinxing@macklin.cn
Country: China
ProdList: 29784
Advantage: 58

Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 18621169109
Email: market03@meryer.com
Country: China
ProdList: 27987
Advantage: 58

Shanghai Haohong Scientific Co., Ltd.

Tel: 400-8210725 4008210725
Email: malulu@leyan.com
Country: China
ProdList: 39845
Advantage: 58

Shanghai Saikerui Biotechnology Co. , Ltd.

Tel: 021-58000709 15900491054
Email: info@scrbio.com
Country: China
ProdList: 9881
Advantage: 58

Shanghai HongTide Biotechnology Co.,Ltd.

Tel: 15318089928
Email: alex@hanhonggroup.com
Country: China
ProdList: 4604
Advantage: 58

Zhongke Huayao (Jiangsu) Biotechnology Co., Ltd

Tel: 13770887460
Email: wenxi@jszkhy.com
Country: China
ProdList: 1354
Advantage: 58

Combio (Suzhou) Ltd.

Tel: 17751201929
Email: office@combiosz.com
Country: China
ProdList: 3000
Advantage: 58

Nanjing Yushengkang Biotechnology Co., Ltd

Tel: 13327808530
Email: 2670965693@qq.com
Country: China
ProdList: 2179
Advantage: 58

Zhejiang Jiekun Biotechnology Co., Ltd

Tel: 0571-88211951 13735575465
Email: sales1@gotopbio.com
Country: China
ProdList: 4880
Advantage: 58

Taiyuan Bailihengkang Biotechnology Co., Ltd

Tel: 19135651983
Email: 18611134419@163.com
Country: China
ProdList: 4416
Advantage: 58

Hangzhou Bingochem Co., Ltd.

Tel: 0571-8512-5372
Email: sales@bingochem.com
Country: China
ProdList: 21669
Advantage: 58

Nanjing Shizhou Biology Technology Co.,Ltd

Tel: 025-85560043 15850508050
Fax: 025-85563444
Email: cindy.huang@synzest.com
Country: China
ProdList: 12000
Advantage: 58

xinguokeji

Tel: 13120711461
Email: 363372932@qq.com
Country: China
ProdList: 498
Advantage: 58

Sichuan BioCrick Biotech Co., Ltd

Tel: 28-86-28-8543-3893 13260669172
Email: sales@biocrick.com
Country: China
ProdList: 5020
Advantage: 58

Tanmo Quality Inspection Technology Co., Ltd.

Tel: 4008-099-669
Email: 23419001name@qq.com
Country: CHINA
ProdList: 6043
Advantage: 58

Hubei Danding Pharmaceutical Technology Co., Ltd

Tel: 17701422019
Email: 1559451077@qq.com
Country: China
ProdList: 8167
Advantage: 58

2854-40-2, CYCLO(-PRO-VAL)Related Search:

CYCLO(-PHE-PRO) MACULOSIN Cyclo(-Phe-Tyr) CYCLO(-MET-PRO) cyclo(Pro-Ser) cyclo(Pro-Asp) cyclo(Pro-Glu) cyclo(Pro-Lys) cyclo(Pro-Asn) cyclo(Pro-Gln) cyclo(Pro-Cys) (S)-3-Isopropyl-2,5-piperazinedione CYCLO(-PRO-VAL) 3-ISOPROPYL-PIPERAZIN-2-ONE (R)-HEXAHYDROPYRROLO[1,2-A]PYRAZIN-1(2H)-ONE (3S)-3-ISOPROPYL-1-METHYLPIPERAZINE (2S)-ISOPROPYLPIPERAZINE

CYCLO(-PRO-VAL)

(3S,8aS)-3-Isopropyl-6,7,8,8aα-tetrahydropyrrolo[1,2-a]pyrazine-1,4(2H,3H)-dione

(3S,8aS)-3β-Isopropyl-6,7,8,8a-tetrahydropyrrolo[1,2-a]pyrazine-1,4(2H,3H)-dione

(3S,8aS)-Octahydro-3-(1-methylethyl)pyrrolo[1,2-a]pyrazine-1,4-dione

(3S,8aα)-3β-Isopropyloctahydropyrrolo[1,2-a]pyrazine-1,4-dione

Cyclo(L-Pro-L-Val-)

Cyclo(L-Val-L-Pro-)

Pyrrolo[1,2-a]pyrazine-1,4-dione, hexahydro-3-(1-methylethyl)-, (3S,8aS)-

(3S,8aS)-3-propan-2-yl-2,3,6,7,8,8a-hexahydropyrrolo[1,2-a]pyrazine-1,4-dione

Cyclo(L-prolyl-L-valyl)

CYCLO(L-PROLYL-L-VALINE)

(3S,8aS)-3-(propan-2-yl)-octahydropyrrolo[1,2-a]p yrazine-1,4-dione

(3S,8aS)-3-Isopropylhexahydropyrrolo[1,2-a]pyrazine-1,4-dione

Cyclo(L-Pro-L-Val),CYCLO(-PRO-VAL)

2854-40-2/5654-87-5

Cyclo(Val-Pro)

c(Pro-Val)

Vildagliptin Impurity 114

2854-40-2