ChemicalBook > CAS DataBase List > N-((S)-1-(((S)-1-Hydroxy-3-Methylbutyl)aMino)-1-oxo-3-phenylpropan-2-yl)pyrazine-2-carboxaMide

N-((S)-1-(((S)-1-Hydroxy-3-Methylbutyl)aMino)-1-oxo-3-phenylpropan-2-yl)pyrazine-2-carboxaMide

Product Name
N-((S)-1-(((S)-1-Hydroxy-3-Methylbutyl)aMino)-1-oxo-3-phenylpropan-2-yl)pyrazine-2-carboxaMide
CAS No.
289472-81-7
Chemical Name
N-((S)-1-(((S)-1-Hydroxy-3-Methylbutyl)aMino)-1-oxo-3-phenylpropan-2-yl)pyrazine-2-carboxaMide
Synonyms
Bortezomib EP IMP M;Bortezomib USP IMP J;Bortezomib Impurity D;Bortezomib Impurity J;Bortezomib Impurity 48;Bortezomib USP Impurity J;BortezomibHydroxy(1S,2S)-Isomer;Bortezomib USP Related Compoud J;(S)-Hydroxy Des(boric Acid) BortezoMib;(S,S)-Bortezomib Hydroxyisopentyl Amide Analog
CBNumber
CB02661665
Molecular Formula
C19H24N4O3
Formula Weight
356.42
MOL File
289472-81-7.mol
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N-((S)-1-(((S)-1-Hydroxy-3-Methylbutyl)aMino)-1-oxo-3-phenylpropan-2-yl)pyrazine-2-carboxaMide Property

Boiling point:
672.0±55.0 °C(Predicted)
Density 
1.199±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
Chloroform (Slightly), Methanol (Slightly)
pka
11.90±0.46(Predicted)
form 
Solid
color 
White to Off-White
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC
Product number
H935905
Product name
(S)-HydroxyDes(boricAcid)Bortezomib
Packaging
5mg
Price
$1455
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CCH0032708
Product name
N-((S)-1-(((S)-1-HYDROXY-3-METHYLBUTYL)AMINO)-1-OXO-3-PHENYLPROPAN-2-YL)PYRAZINE-2-CARBOXAMIDE
Purity
95.00%
Packaging
5MG
Price
$496.22
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CCH0032708
Product name
N-((S)-1-(((S)-1-HYDROXY-3-METHYLBUTYL)AMINO)-1-OXO-3-PHENYLPROPAN-2-YL)PYRAZINE-2-CARBOXAMIDE
Purity
95.00%
Packaging
1G
Price
$1365
Updated
2021/12/16
Crysdot
Product number
CD11152974
Product name
N-((S)-1-(((S)-1-Hydroxy-3-methylbutyl)amino)-1-oxo-3-phenylpropan-2-yl)pyrazine-2-carboxamide
Purity
95+%
Packaging
1g
Price
$947
Updated
2021/12/16
Chemenu
Product number
CM168043
Product name
N-((S)-1-(((S)-1-hydroxy-3-methylbutyl)amino)-1-oxo-3-phenylpropan-2-yl)pyrazine-2-carboxamide
Purity
95%+
Packaging
1g
Price
$1365
Updated
2021/12/16
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N-((S)-1-(((S)-1-Hydroxy-3-Methylbutyl)aMino)-1-oxo-3-phenylpropan-2-yl)pyrazine-2-carboxaMide Chemical Properties,Usage,Production

Uses

(S)-Hydroxy Des(boric Acid) Bortezomib is an impurity in the synthesis of Bortezomib (B675700), the first proteasome inhibitor to be approved by the US FDA for multiple myeloma, a blood cancer. A reversible inhibitor of the 26S proteasome-a barrel-shaped multiprotein particle found in the nucleus and cytosol of all eukaryotic cells. Targets the ubiquitin-proteasome pathway.

N-((S)-1-(((S)-1-Hydroxy-3-Methylbutyl)aMino)-1-oxo-3-phenylpropan-2-yl)pyrazine-2-carboxaMide Preparation Products And Raw materials

Raw materials

Preparation Products

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N-((S)-1-(((S)-1-Hydroxy-3-Methylbutyl)aMino)-1-oxo-3-phenylpropan-2-yl)pyrazine-2-carboxaMide Suppliers

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289472-81-7, N-((S)-1-(((S)-1-Hydroxy-3-Methylbutyl)aMino)-1-oxo-3-phenylpropan-2-yl)pyrazine-2-carboxaMideRelated Search:

2,3-Pyrazinedicarboxylic acid Bortezomib Impurity 35 Bortezomib Impurity 23 tert-Butyl Tosylate DISCONTINUED Bortezomib Impurity 5 1-Chloro-2-methylpropane Bortezomib Impurity 45 BOC-D-Phenylalanine bortezoMib iMpurity H Boronic acid, B-[(1S)-3-Methyl-1-[[(2R)-1-oxo-3-phenyl-2-[(2-pyrazinylcarbonyl)aMino]propyl]aMino]butyl]- 2-PyrazinecarboxaMide, N-[(1S)-2-[[(1R)-1-hydroperoxy-3-Methylbutyl]aMino]-2-oxo-1-(phenylMethyl)ethyl]- (S)-N-(1-AMino-1-oxo-3-phenylpropan-2-yl)pyrazine-2-carboxaMide ((R)-3-Methyl-1-((R)-3-phenyl-2-(pyrazine-2-carboxaMido)propanaMido)butyl)boronic acid 2-PyrazinecarboxaMide, N-[(1S)-2-[[(1S)-1-hydroperoxy-3-Methylbutyl]aMino]-2-oxo-1-(phenylMethyl)ethyl]- N-((S)-1-(((R)-1-Hydroxy-3-Methylbutyl)aMino)-1-oxo-3-phenylpropan-2-yl)pyrazine-2-carboxaMide ((S)-3-Methyl-1-((S)-3-phenyl-2-(pyrazine-2-carboxaMido)propanaMido)butyl)boronic acid Bortezomib Impurity 47 HCl 1-Bromo-2-methylpropane

  • 2-PyrazinecarboxaMide, N-[(1S)-2-[[(1S)-1-hydroxy-3-Methylbutyl]aMino]-2-oxo-1-(phenylMethyl)ethyl]-
  • (S)-Hydroxy Des(boric Acid) BortezoMib
  • Bortezomib Impurity 48
  • Bortezomib Impurity J
  • N-[(2S)-1-[[(1S)-1-hydroxy-3-methylbutyl]amino]-1-oxo-3-phenylpropan-2-yl]pyrazine-2-carboxamide
  • Bortezomib USP IMP J
  • (N-[(1S)-1-hydroxy-3-Methylbutyl]-Nα-(pyrazin-2-ylcarbonyl)-L-phenylalaninaMide
  • Bortezomib Impurity D
  • Bortezomib USP Related Compoud J
  • N-[(1S)-2-[[(1S)-1-hydroxy-3-methylbutyl]amino]-2-oxo-1-(phenylmethyl)ethyl]-2-Pyrazinecarboxamide
  • N-[(1S)-2-[[(1S)-1-hydroxy-3-methylbutyl]amino]-2-oxo-1-(phenylmethyl)ethyl]-pyrazi
  • Bortezomib USP Impurity J
  • Bortezomib Related Compund J/ (S,S)-Bortezomib Hydroxyisopentyl Amide Analog (Bortezomib Hydroxy S,S-Isomer Impurity)
  • BortezomibHydroxy(1S,2S)-Isomer
  • (S,S)-Bortezomib Hydroxyisopentyl Amide Analog
  • Bortezomib EP IMP M
  • N-[(2S)-1-[[(1S)-1-hydroxy-3-methylbutyl]amino]-1-oxo-3-phenylprop
  • N-((S)-1-(((S)-1-Hydroxy-3-Methylbutyl)aMino)-1-oxo-3-phenyl
  • 289472-81-7
  • Metabolites & Impurities, Pharmaceuticals, Intermediates & Fine Chemicals