N-((S)-1-(((S)-1-Hydroxy-3-Methylbutyl)aMino)-1-oxo-3-phenylpropan-2-yl)pyrazine-2-carboxaMide

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N-((S)-1-(((S)-1-Hydroxy-3-Methylbutyl)aMino)-1-oxo-3-phenylpropan-2-yl)pyrazine-2-carboxaMide

Product Name: N-((S)-1-(((S)-1-Hydroxy-3-Methylbutyl)aMino)-1-oxo-3-phenylpropan-2-yl)pyrazine-2-carboxaMide
CAS No.: 289472-81-7
Chemical Name: N-((S)-1-(((S)-1-Hydroxy-3-Methylbutyl)aMino)-1-oxo-3-phenylpropan-2-yl)pyrazine-2-carboxaMide
Synonyms: Bortezomib EP IMP M;Bortezomib USP IMP J;Bortezomib Impurity D;Bortezomib Impurity J;Bortezomib Impurity 48;Bortezomib impurity 90;Bortezomib USP Impurity J;BortezomibHydroxy(1S,2S)-Isomer;Bortezomib USP Related Compoud J;(S)-Hydroxy Des(boric Acid) BortezoMib
CBNumber: CB02661665
Molecular Formula: C19H24N4O3
Formula Weight: 356.42
MOL File: 289472-81-7.mol

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N-((S)-1-(((S)-1-Hydroxy-3-Methylbutyl)aMino)-1-oxo-3-phenylpropan-2-yl)pyrazine-2-carboxaMide Property

Boiling point:: 672.0±55.0 °C(Predicted)
Density: 1.199±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: Chloroform (Slightly), Methanol (Slightly)
pka: 11.90±0.46(Predicted)
form: Solid
color: White to Off-White

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: H935905
Product name: (S)-HydroxyDes(boricAcid)Bortezomib
Packaging: 5mg
Price: $1455
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CCH0032708
Product name: N-((S)-1-(((S)-1-HYDROXY-3-METHYLBUTYL)AMINO)-1-OXO-3-PHENYLPROPAN-2-YL)PYRAZINE-2-CARBOXAMIDE
Purity: 95.00%
Packaging: 5MG
Price: $496.22
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CCH0032708
Product name: N-((S)-1-(((S)-1-HYDROXY-3-METHYLBUTYL)AMINO)-1-OXO-3-PHENYLPROPAN-2-YL)PYRAZINE-2-CARBOXAMIDE
Purity: 95.00%
Packaging: 1G
Price: $1365
Updated: 2021/12/16

Crysdot

Product number: CD11152974
Product name: N-((S)-1-(((S)-1-Hydroxy-3-methylbutyl)amino)-1-oxo-3-phenylpropan-2-yl)pyrazine-2-carboxamide
Purity: 95+%
Packaging: 1g
Price: $947
Updated: 2021/12/16

Chemenu

Product number: CM168043
Product name: N-((S)-1-(((S)-1-hydroxy-3-methylbutyl)amino)-1-oxo-3-phenylpropan-2-yl)pyrazine-2-carboxamide
Purity: 95%+
Packaging: 1g
Price: $1365
Updated: 2021/12/16

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N-((S)-1-(((S)-1-Hydroxy-3-Methylbutyl)aMino)-1-oxo-3-phenylpropan-2-yl)pyrazine-2-carboxaMide Chemical Properties,Usage,Production

Uses

(S)-Hydroxy Des(boric Acid) Bortezomib is an impurity in the synthesis of Bortezomib (B675700), the first proteasome inhibitor to be approved by the US FDA for multiple myeloma, a blood cancer. A reversible inhibitor of the 26S proteasome-a barrel-shaped multiprotein particle found in the nucleus and cytosol of all eukaryotic cells. Targets the ubiquitin-proteasome pathway.

N-((S)-1-(((S)-1-Hydroxy-3-Methylbutyl)aMino)-1-oxo-3-phenylpropan-2-yl)pyrazine-2-carboxaMide Preparation Products And Raw materials

Raw materials

Preparation Products

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289472-81-7, N-((S)-1-(((S)-1-Hydroxy-3-Methylbutyl)aMino)-1-oxo-3-phenylpropan-2-yl)pyrazine-2-carboxaMideRelated Search:

2,3-Pyrazinedicarboxylic acid Bortezomib Impurity 35 Bortezomib Impurity 23 tert-Butyl Tosylate DISCONTINUED Bortezomib Impurity 5 1-Chloro-2-methylpropane Bortezomib Impurity 45 BOC-D-Phenylalanine bortezoMib iMpurity H Boronic acid, B-[(1S)-3-Methyl-1-[[(2R)-1-oxo-3-phenyl-2-[(2-pyrazinylcarbonyl)aMino]propyl]aMino]butyl]- 2-PyrazinecarboxaMide, N-[(1S)-2-[[(1R)-1-hydroperoxy-3-Methylbutyl]aMino]-2-oxo-1-(phenylMethyl)ethyl]- (S)-N-(1-AMino-1-oxo-3-phenylpropan-2-yl)pyrazine-2-carboxaMide ((R)-3-Methyl-1-((R)-3-phenyl-2-(pyrazine-2-carboxaMido)propanaMido)butyl)boronic acid 2-PyrazinecarboxaMide, N-[(1S)-2-[[(1S)-1-hydroperoxy-3-Methylbutyl]aMino]-2-oxo-1-(phenylMethyl)ethyl]- N-((S)-1-(((R)-1-Hydroxy-3-Methylbutyl)aMino)-1-oxo-3-phenylpropan-2-yl)pyrazine-2-carboxaMide ((S)-3-Methyl-1-((S)-3-phenyl-2-(pyrazine-2-carboxaMido)propanaMido)butyl)boronic acid Bortezomib Impurity 47 HCl 1-Bromo-2-methylpropane

2-PyrazinecarboxaMide, N-[(1S)-2-[[(1S)-1-hydroxy-3-Methylbutyl]aMino]-2-oxo-1-(phenylMethyl)ethyl]-

(S)-Hydroxy Des(boric Acid) BortezoMib

Bortezomib Impurity 48

Bortezomib Impurity J

N-[(2S)-1-[[(1S)-1-hydroxy-3-methylbutyl]amino]-1-oxo-3-phenylpropan-2-yl]pyrazine-2-carboxamide

Bortezomib USP IMP J

(N-[(1S)-1-hydroxy-3-Methylbutyl]-Nα-(pyrazin-2-ylcarbonyl)-L-phenylalaninaMide

Bortezomib Impurity D

Bortezomib USP Related Compoud J

N-[(1S)-2-[[(1S)-1-hydroxy-3-methylbutyl]amino]-2-oxo-1-(phenylmethyl)ethyl]-2-Pyrazinecarboxamide

N-[(1S)-2-[[(1S)-1-hydroxy-3-methylbutyl]amino]-2-oxo-1-(phenylmethyl)ethyl]-pyrazi

Bortezomib USP Impurity J

Bortezomib Related Compund J/ (S,S)-Bortezomib Hydroxyisopentyl Amide Analog (Bortezomib Hydroxy S,S-Isomer Impurity)

BortezomibHydroxy(1S,2S)-Isomer

(S,S)-Bortezomib Hydroxyisopentyl Amide Analog

Bortezomib EP IMP M

N-[(2S)-1-[[(1S)-1-hydroxy-3-methylbutyl]amino]-1-oxo-3-phenylprop

N-((S)-1-(((S)-1-Hydroxy-3-Methylbutyl)aMino)-1-oxo-3-phenyl

N-((S)-1-(((S)-1-Hydroxy-3-Methylbutyl)aMino)-1-oxo-3-phenylpropan-2-yl)pyrazine-2-carboxaMide

Bortezomib impurity 90

289472-81-7

Metabolites & Impurities, Pharmaceuticals, Intermediates & Fine Chemicals