ChemicalBook > CAS DataBase List > 1H-BenziMidazole, 6-(2-chloro-5-fluoro-4-pyriMidinyl)-4-fluoro-2-Methyl-1-(1-Methylethyl)-

1H-BenziMidazole, 6-(2-chloro-5-fluoro-4-pyriMidinyl)-4-fluoro-2-Methyl-1-(1-Methylethyl)-

Product Name
1H-BenziMidazole, 6-(2-chloro-5-fluoro-4-pyriMidinyl)-4-fluoro-2-Methyl-1-(1-Methylethyl)-
CAS No.
1231930-42-9
Chemical Name
1H-BenziMidazole, 6-(2-chloro-5-fluoro-4-pyriMidinyl)-4-fluoro-2-Methyl-1-(1-Methylethyl)-
Synonyms
6-(2-chloro-5-fluoropyriMidin-4-yl)-4-fluoro-1-isopropyl-2-Methyl-1H-benzo[d]iMidazole;Abemaciclib Impurity 3;LY2835219 intermediate;Abemaciclib impurity A;Abemaciclib Impurity N3;Abemaciclib intermediate;6-(2-chloro-5-fluoropyriMidin-4-yl)-4-fluoro;6-(2-chloro-5-fluoro-4-pyrimidinyl)-4-fluoro-2-methyl-1-(1-m...;6-(2-Chloro-5-fluoro-4-pyrimidinyl)-4-fluoro-1-isopropyl-2-methylbenzimidazole;6-(2-chloro-5-fluoropyrimidin-4-yl)-4-fluoro-1-isopropyl-2-methyl-1H-benzimidazole
CBNumber
CB02668114
Molecular Formula
C15H13ClF2N4
Formula Weight
322.74
MOL File
1231930-42-9.mol
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1H-BenziMidazole, 6-(2-chloro-5-fluoro-4-pyriMidinyl)-4-fluoro-2-Methyl-1-(1-Methylethyl)- Property

Boiling point:
509.6±45.0 °C(Predicted)
Density 
1.42±0.1 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
pka
2.32±0.10(Predicted)
Appearance
Off-white to light yellow Solid
InChI
InChI=1S/C15H13ClF2N4/c1-7(2)22-8(3)20-14-10(17)4-9(5-12(14)22)13-11(18)6-19-15(16)21-13/h4-7H,1-3H3
InChIKey
BDVDXNYOCBUMNP-UHFFFAOYSA-N
SMILES
C1(C)N(C(C)C)C2=CC(C3C(F)=CN=C(Cl)N=3)=CC(F)=C2N=1
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
C368873
Product name
6-(2-Chloro-5-fluoropyrimidin-4-yl)-4-fluoro-2-methyl-1-(propan-2-yl)-1H-1,3-benzodiazole
Packaging
500mg
Price
$110
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0620738
Product name
6-(2-CHLORO-5-FLUOROPYRIMIDIN-4-YL)-4-FLUORO-1-ISOPROPYL-2-METHYL-1H-BENZO[D]IMIDAZOLE
Purity
95.00%
Packaging
5MG
Price
$501.69
Updated
2021/12/16
AK Scientific
Product number
1695DY
Product name
6-(2-Chloro-5-fluoropyrimidin-4-yl)-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole
Packaging
1g
Price
$147
Updated
2021/12/16
Ambeed
Product number
A209941
Product name
6-(2-Chloro-5-fluoropyrimidin-4-yl)-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole
Purity
97%
Packaging
10g
Price
$200
Updated
2021/12/16
Chemenu
Product number
CM161840
Product name
6-(2-chloro-5-fluoropyrimidin-4-yl)-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole
Purity
95%
Packaging
5g
Price
$224
Updated
2021/12/16
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1H-BenziMidazole, 6-(2-chloro-5-fluoro-4-pyriMidinyl)-4-fluoro-2-Methyl-1-(1-Methylethyl)- Chemical Properties,Usage,Production

Flammability and Explosibility

Not classified

Synthesis

1231930-37-2

2927-71-1

1231930-42-9

The general procedure for the synthesis of 6-(2-chloro-5-fluoropyrimidin-4-yl)-4-fluoro-1-isopropyl-2-methyl-6-boronic acid pinacol esteryl-1H-benzo[d]imidazole from 4-fluoro-1-isopropyl-2-methyl-6-boronic acid pinacol esteryl-1H-benzo[d]imidazole and 2,4-dichloro-5-fluoropyrimidine was carried out in the following manner: under nitrogen protection, the synthesized 6-(2-chloro-5-fluoropyrimidin-4-yl)-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole was prepared by applying the following method to the 4-fluoro-1-isopropyl-2-methyl-6-(4 ,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-benzo[d]imidazole (318 mg, 1 mmol) and 2,4-dichloro-5-fluoropyrimidine (166 mg, 1 mmol) in suspension in 6 mL of acetonitrile was added to tetrakis(triphenylphosphine)palladium (115.6 mg, 0.1 mmol) and 2 mL of a saturated sodium carbonate aqueous solution. The reaction mixture was heated to 85 °C and stirred for 8 hours. After completion of the reaction, it was cooled to room temperature and extracted with a solvent mixture of chloroform and isopropanol (4:1, v/v). The organic layers were combined, washed with saturated saline, dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography with the eluent being a mixture of dichloromethane and methanol (methanol v/v 0-10%) to afford 6-(2-chloro-5-fluoropyrimidin-4-yl)-4-fluoro-1-isopropyl-2-methyl-1H-benzoimidazole (277 mg, 86% yield) as a gray solid.LC-MS (m/z): 323.1 [M+H]+.

References

[1] Patent: WO2017/185031, 2017, A1. Location in patent: Page/Page column 96
[2] Tetrahedron Letters, 2015, vol. 56, # 7, p. 949 - 951
[3] Patent: US2010/160340, 2010, A1. Location in patent: Page/Page column 11
[4] Patent: WO2015/130540, 2015, A1. Location in patent: Page/Page column 22-23
[5] Patent: CN107266421, 2017, A. Location in patent: Paragraph 0043; 0052; 0053

1H-BenziMidazole, 6-(2-chloro-5-fluoro-4-pyriMidinyl)-4-fluoro-2-Methyl-1-(1-Methylethyl)- Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 1H-BenziMidazole, 6-(2-chloro-5-fluoro-4-pyriMidinyl)-4-fluoro-2-Methyl-1-(1-Methylethyl)- manufacturers

Shaanxi Dideu New Materials Co. Ltd
Product
LY2835219 intermediate 1231930-42-9
Price
US $0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1000kg
Release date
2025-05-16
Yangzhou Qinyuan Pharmatech Co.,ltd
Product
1H-BenziMidazole, 6-(2-chloro-5-fluoro-4-pyriMidinyl)-4-fluoro-2-Methyl-1-(1-Methylethyl) 1231930-42-9
Price
US $10.00/g
Min. Order
10g
Purity
0.99
Supply Ability
1ton
Release date
2025-05-14
Henan Fengda Chemical Co., Ltd
Product
1H-BenziMidazole, 6-(2-chloro-5-fluoro-4-pyriMidinyl)-4-fluoro-2-Methyl-1-(1-Methylethyl)- 1231930-42-9
Price
US $5.00-0.10/KG
Min. Order
1KG
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2024-04-15

1231930-42-9, 1H-BenziMidazole, 6-(2-chloro-5-fluoro-4-pyriMidinyl)-4-fluoro-2-Methyl-1-(1-Methylethyl)-Related Search:

1H-BenziMidazole, 4-fluoro-2-Methyl-1-(1-Methylethyl)-6-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)- 6-Bromo-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole 2-bromo-8-fluoro-4,5-dihydro-1H-azepino[5,4,3-cd]indol-6(3H)-one PF-01367338 5-((4-Ethylpiperazin-1-yl)methyl)pyridin-2-amine 4-(8-fluoro-6-oxo-3,4,5,6-tetrahydro-1H-azepino[5,4,3-cd]indol-2-yl)benzaldehyde

  • 1H-BenziMidazole, 6-(2-chloro-5-fluoro-4-pyriMidinyl)-4-fluoro-2-Methyl-1-(1-Methylethyl)-
  • 6-(2-chloro-5-fluoropyriMidin-4-yl)-4-fluoro-1-isopropyl-2-Methyl-1H-benzo[d]iMidazole
  • 6-(2-chloro-5-fluoro-pyrimidin-4-yl)-4-fluoro-1-isopropyl-2-methyl-1H-benzoimidazole
  • 6-(2-chloro-5-fluoropyriMidin-4-yl)-4-fluoro
  • 6-(2-chloro-5-fluoro-4-pyriMidinyl)-4-fluoro-2-Methyl-1-(1-Methylethyl)-1H-BenziMidazole
  • LY2835219 intermediate
  • 6-(2-chloro-5-fluoropyrimidin-4-yl)-4-fluoro-2-methyl-1-(propan-2-yl)-1H-1,3-benzodiazole
  • Abemaciclib intermediate
  • 1H-BenziMidazole, 6-(2-chloro-5-fluoro-4-pyriMidinyl)-4-fluoro-2-Methyl-1-(1-Methylethy
  • 6-(2-Chloro-5-fluoro-4-pyrimidinyl)-4-fluoro-1-isopropyl-2-methylbenzimidazole
  • Abemaciclib Impurity 3
  • 6-(2-chloro-5-fluoro-4-pyrimidinyl)-4-fluoro-2-methyl-1-(1-m...
  • 6-(2-Chloro-5-fluoro-4-pyrimidinyl)-4-fluoro-2-meth yl-1-(1-methylethy)-LH-benzimidazol
  • Abemaciclib Impurity N3
  • 6-(2-chloro-5-fluoropyrimidin-4-yl)-4-fluoro-1-isopropyl-2-methyl-1H-benzimidazole
  • Abemaciclib impurity A
  • 1231930-42-9
  • 231930-42-9