5-((4-Ethylpiperazin-1-yl)methyl)pyridin-2-amine

Physical Form

Product Name: 5-((4-Ethylpiperazin-1-yl)methyl)pyridin-2-amine
CAS No.: 1180132-17-5
Chemical Name: 5-((4-Ethylpiperazin-1-yl)methyl)pyridin-2-amine
Synonyms: Abemaciclib Impurity 4;LY2835219 Intermediate 1;5-[(4-ethyl-1-piperazinyl)methyl]-2-pyridin;5-((4-Ethylpiperazin-1-y)methyDpyridin-2-amine;5-((4-ethylpiperazin-1-yl)methyl)pyridin-2-amin;-((4-Ethylpiperazin-1-yl)Methyl)pyridin-2-aMine;5-((4-Ethylpiperazin-1-yl)methyl)pyridin-2-amine;5-[(4-Ethyl-1-piperazinyl)methyl]-2-pyridinamine;2-Amino-5-[(4-ethyl-1-piperazinyl)methyl]pyridine;5-((4-ethylpiperazin-1-yl)methyl)pyridine-2-amine
CBNumber: CB72500105
Molecular Formula: C12H20N4
Formula Weight: 220.31
MOL File: 1180132-17-5.mol

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5-((4-Ethylpiperazin-1-yl)methyl)pyridin-2-amine Property

Boiling point:: 362℃
Density: 1.101
Flash point:: 173℃
storage temp.: 2-8°C(protect from light)
pka: 7.71±0.10(Predicted)
Appearance: White to yellow Solid
InChI: InChI=1S/C12H20N4/c1-2-15-5-7-16(8-6-15)10-11-3-4-12(13)14-9-11/h3-4,9H,2,5-8,10H2,1H3,(H2,13,14)
InChIKey: MNJBMPQTXVZMFZ-UHFFFAOYSA-N
SMILES: C1(N)=NC=C(CN2CCN(CC)CC2)C=C1

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Safety

HS Code: 2933599590

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H318Causes serious eye damage

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC

Product number: E926858
Product name: 5-((4-Ethylpiperazin-1-yl)methyl)pyridin-2-amine
Packaging: 100mg
Price: $60
Updated: 2021/12/16

TRC

Product number: E926858
Product name: 5-((4-Ethylpiperazin-1-yl)methyl)pyridin-2-amine
Packaging: 500mg
Price: $155
Updated: 2021/12/16

AK Scientific

Product number: 2951AA
Product name: 5-((4-Ethylpiperazin-1-yl)methyl)pyridin-2-amine
Packaging: 5g
Price: $195
Updated: 2021/12/16

Apolloscientific

Product number: OR471684
Product name: 2-Amino-5-[(4-ethyl-1-piperazinyl)methyl]pyridine
Packaging: 5g
Price: $226
Updated: 2021/12/16

SynQuest Laboratories

Product number: 3H30-1-KV
Product name: 2-Amino-5-[(4-ethyl-1-piperazinyl)methyl]pyridine
Purity: 95%
Packaging: 5G
Price: $268
Updated: 2021/12/16

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5-((4-Ethylpiperazin-1-yl)methyl)pyridin-2-amine Chemical Properties,Usage,Production

Physical Form

Solid

Uses

5-((4-Ethylpiperazin-1-yl)methyl)pyridin-2-amine is a useful research chemical.

Flammability and Explosibility

Not classified

Synthesis

121-44-8

156973-09-0

1180132-17-5

To a 500 mL four-necked round-bottomed flask equipped with a thermometer and condenser tube were added 100 g of 1,2-dichloroethane, 12.5 g (0.1 mol) of 5-(aminomethyl)pyridin-2-amine (IV) and 30.0 g of potassium carbonate. A solution consisting of 25.0 g (0.15 mol) N,N-diethylethylamine and 20 g of 1,2-dichloroethane was added slowly and dropwise over a period of about 2 hours at 30 to 35 °C. The reaction temperature was maintained at 30~35°C and stirring was continued for 6 hours. After completion of the reaction, it was cooled to 20~25°C and layered. The aqueous layer was extracted twice with 1,2-dichloroethane at 20 g. The organic phases were combined and the 1,2-dichloroethane was removed by distillation. To the residue was added 75 g of methyl tert-butyl ether and 0.5 g of activated charcoal and stirred at 80~82°C for 1 hr. After hot filtration, the filtrate was cooled to 0~5°C for crystallization, filtered and dried to afford 18.2 g of 5-((4-ethylpiperazin-1-yl)methyl)pyridin-2-amine as a white solid in 82.7% yield and 99.3% purity of the liquid phase.

References

[1] Patent: CN107337634, 2017, A. Location in patent: Paragraph 0040; 0053; 0054; 0057; 0058; 0061; 0062

5-((4-Ethylpiperazin-1-yl)methyl)pyridin-2-amine Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 5-((4-Ethylpiperazin-1-yl)methyl)pyridin-2-amine manufacturers

Jinan Ruitong Biotech Co., Ltd.

Product: 5-((4-ethylpiperazin-1-yl)methyl)pyridine-2-amine 1180132-17-5
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 1
Release date: 2025-08-28

Shaanxi Dideu New Materials Co. Ltd

Product: 5-((4-Ethylpiperazin-1-yl)methyl)pyridin-2-amine 1180132-17-5
Price: US $0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1000kg
Release date: 2025-06-10

Yangzhou Qinyuan Pharmatech Co.,ltd

Product: 5-((4-Ethylpiperazin-1-yl)methyl)pyridin-2-amine 1180132-17-5
Price: US $10.00/g
Min. Order: 10g
Purity: 0.99
Supply Ability: 1ton
Release date: 2025-05-14

1180132-17-5, 5-((4-Ethylpiperazin-1-yl)methyl)pyridin-2-amineRelated Search:

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5-((4-Ethylpiperazin-1-yl)methyl)pyridin-2-amine

[5-[(4-Ethylpiperazin-1-yl)methyl]pyridin-2-yl]amine

5-[(4-Ethyl-1-piperazinyl)methyl]-2-pyridinamine

2-PyridinaMine, 5-[(4-ethyl-1-piperazinyl)Methyl]-

-((4-Ethylpiperazin-1-yl)Methyl)pyridin-2-aMine

5-((4-ethylpiperazin-1-yl)methyl)pyridin-2-amin

LY2835219 Intermediate 1

2-Amino-5-[(4-ethyl-1-piperazinyl)methyl]pyridine

Abemaciclib Impurity 4

5-((4-Ethylpiperazin-1-yl)methyl)pyridin-2-amine ISO 9001：2015 REACH

5-[(4-ethyl-1-piperazinyl)methyl]-2-pyridin

5-((4-Ethylpiperazin-1-y)methyDpyridin-2-amine

5-((4-ethylpiperazin-1-yl)methyl)pyridine-2-amine

1180132-17-5