1H-BenziMidazole, 6-(2-chloro-5-fluoro-4-pyriMidinyl)-4-fluoro-2-Methyl-1-(1-Methylethyl)-

Product Name: 1H-BenziMidazole, 6-(2-chloro-5-fluoro-4-pyriMidinyl)-4-fluoro-2-Methyl-1-(1-Methylethyl)-
CAS No.: 1231930-42-9
Chemical Name: 1H-BenziMidazole, 6-(2-chloro-5-fluoro-4-pyriMidinyl)-4-fluoro-2-Methyl-1-(1-Methylethyl)-
Synonyms: 6-(2-chloro-5-fluoropyriMidin-4-yl)-4-fluoro-1-isopropyl-2-Methyl-1H-benzo[d]iMidazole;Abemaciclib Impurity 3;LY2835219 intermediate;Abemaciclib impurity A;Abemaciclib Impurity N3;Abemaciclib intermediate;6-(2-chloro-5-fluoropyriMidin-4-yl)-4-fluoro;6-(2-chloro-5-fluoro-4-pyrimidinyl)-4-fluoro-2-methyl-1-(1-m...;6-(2-Chloro-5-fluoro-4-pyrimidinyl)-4-fluoro-1-isopropyl-2-methylbenzimidazole;6-(2-chloro-5-fluoropyrimidin-4-yl)-4-fluoro-1-isopropyl-2-methyl-1H-benzimidazole
CBNumber: CB02668114
Molecular Formula: C15H13ClF2N4
Formula Weight: 322.74
MOL File: 1231930-42-9.mol

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1H-BenziMidazole, 6-(2-chloro-5-fluoro-4-pyriMidinyl)-4-fluoro-2-Methyl-1-(1-Methylethyl)- Property

Boiling point:: 509.6±45.0 °C(Predicted)
Density: 1.42±0.1 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: 2.32±0.10(Predicted)
Appearance: Off-white to light yellow Solid
InChI: InChI=1S/C15H13ClF2N4/c1-7(2)22-8(3)20-14-10(17)4-9(5-12(14)22)13-11(18)6-19-15(16)21-13/h4-7H,1-3H3
InChIKey: BDVDXNYOCBUMNP-UHFFFAOYSA-N
SMILES: C1(C)N(C(C)C)C2=CC(C3C(F)=CN=C(Cl)N=3)=CC(F)=C2N=1

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: C368873
Product name: 6-(2-Chloro-5-fluoropyrimidin-4-yl)-4-fluoro-2-methyl-1-(propan-2-yl)-1H-1,3-benzodiazole
Packaging: 500mg
Price: $110
Updated: 2021/12/16

AK Scientific

Product number: 1695DY
Product name: 6-(2-Chloro-5-fluoropyrimidin-4-yl)-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole
Packaging: 1g
Price: $147
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0620738
Product name: 6-(2-CHLORO-5-FLUOROPYRIMIDIN-4-YL)-4-FLUORO-1-ISOPROPYL-2-METHYL-1H-BENZO[D]IMIDAZOLE
Purity: 95.00%
Packaging: 5MG
Price: $501.69
Updated: 2021/12/16

Ambeed

Product number: A209941
Product name: 6-(2-Chloro-5-fluoropyrimidin-4-yl)-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole
Purity: 97%
Packaging: 100mg
Price: $12
Updated: 2021/12/16

Ambeed

Product number: A209941
Product name: 6-(2-Chloro-5-fluoropyrimidin-4-yl)-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole
Purity: 97%
Packaging: 250mg
Price: $18
Updated: 2021/12/16

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1H-BenziMidazole, 6-(2-chloro-5-fluoro-4-pyriMidinyl)-4-fluoro-2-Methyl-1-(1-Methylethyl)- Chemical Properties,Usage,Production

Flammability and Explosibility

Not classified

Synthesis

1231930-37-2

2927-71-1

1231930-42-9

The general procedure for the synthesis of 6-(2-chloro-5-fluoropyrimidin-4-yl)-4-fluoro-1-isopropyl-2-methyl-6-boronic acid pinacol esteryl-1H-benzo[d]imidazole from 4-fluoro-1-isopropyl-2-methyl-6-boronic acid pinacol esteryl-1H-benzo[d]imidazole and 2,4-dichloro-5-fluoropyrimidine was carried out in the following manner: under nitrogen protection, the synthesized 6-(2-chloro-5-fluoropyrimidin-4-yl)-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole was prepared by applying the following method to the 4-fluoro-1-isopropyl-2-methyl-6-(4 ,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-benzo[d]imidazole (318 mg, 1 mmol) and 2,4-dichloro-5-fluoropyrimidine (166 mg, 1 mmol) in suspension in 6 mL of acetonitrile was added to tetrakis(triphenylphosphine)palladium (115.6 mg, 0.1 mmol) and 2 mL of a saturated sodium carbonate aqueous solution. The reaction mixture was heated to 85 °C and stirred for 8 hours. After completion of the reaction, it was cooled to room temperature and extracted with a solvent mixture of chloroform and isopropanol (4:1, v/v). The organic layers were combined, washed with saturated saline, dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography with the eluent being a mixture of dichloromethane and methanol (methanol v/v 0-10%) to afford 6-(2-chloro-5-fluoropyrimidin-4-yl)-4-fluoro-1-isopropyl-2-methyl-1H-benzoimidazole (277 mg, 86% yield) as a gray solid.LC-MS (m/z): 323.1 [M+H]+.

References

[1] Patent: WO2017/185031, 2017, A1. Location in patent: Page/Page column 96
[2] Tetrahedron Letters, 2015, vol. 56, # 7, p. 949 - 951
[3] Patent: US2010/160340, 2010, A1. Location in patent: Page/Page column 11
[4] Patent: WO2015/130540, 2015, A1. Location in patent: Page/Page column 22-23
[5] Patent: CN107266421, 2017, A. Location in patent: Paragraph 0043; 0052; 0053

1H-BenziMidazole, 6-(2-chloro-5-fluoro-4-pyriMidinyl)-4-fluoro-2-Methyl-1-(1-Methylethyl)- Preparation Products And Raw materials

Raw materials

Preparation Products

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1H-BenziMidazole, 6-(2-chloro-5-fluoro-4-pyriMidinyl)-4-fluoro-2-Methyl-1-(1-Methylethyl)- Suppliers

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View Lastest Price from 1H-BenziMidazole, 6-(2-chloro-5-fluoro-4-pyriMidinyl)-4-fluoro-2-Methyl-1-(1-Methylethyl)- manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: LY2835219 intermediate 1231930-42-9
Price: US $0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1000kg
Release date: 2025-05-16

Yangzhou Qinyuan Pharmatech Co.,ltd

Product: 1H-BenziMidazole, 6-(2-chloro-5-fluoro-4-pyriMidinyl)-4-fluoro-2-Methyl-1-(1-Methylethyl) 1231930-42-9
Price: US $10.00/g
Min. Order: 10g
Purity: 0.99
Supply Ability: 1ton
Release date: 2025-05-14

Henan Fengda Chemical Co., Ltd

Product: 1H-BenziMidazole, 6-(2-chloro-5-fluoro-4-pyriMidinyl)-4-fluoro-2-Methyl-1-(1-Methylethyl)- 1231930-42-9
Price: US $5.00-0.10/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-04-15

1231930-42-9, 1H-BenziMidazole, 6-(2-chloro-5-fluoro-4-pyriMidinyl)-4-fluoro-2-Methyl-1-(1-Methylethyl)-Related Search:

1H-BenziMidazole, 4-fluoro-2-Methyl-1-(1-Methylethyl)-6-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)- 6-Bromo-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole 2-bromo-8-fluoro-4,5-dihydro-1H-azepino[5,4,3-cd]indol-6(3H)-one PF-01367338 5-((4-Ethylpiperazin-1-yl)methyl)pyridin-2-amine 4-(8-fluoro-6-oxo-3,4,5,6-tetrahydro-1H-azepino[5,4,3-cd]indol-2-yl)benzaldehyde

1H-BenziMidazole, 6-(2-chloro-5-fluoro-4-pyriMidinyl)-4-fluoro-2-Methyl-1-(1-Methylethyl)-

6-(2-chloro-5-fluoropyriMidin-4-yl)-4-fluoro-1-isopropyl-2-Methyl-1H-benzo[d]iMidazole

6-(2-chloro-5-fluoro-pyrimidin-4-yl)-4-fluoro-1-isopropyl-2-methyl-1H-benzoimidazole

6-(2-chloro-5-fluoropyriMidin-4-yl)-4-fluoro

6-(2-chloro-5-fluoro-4-pyriMidinyl)-4-fluoro-2-Methyl-1-(1-Methylethyl)-1H-BenziMidazole

LY2835219 intermediate

6-(2-chloro-5-fluoropyrimidin-4-yl)-4-fluoro-2-methyl-1-(propan-2-yl)-1H-1,3-benzodiazole

Abemaciclib intermediate

1H-BenziMidazole, 6-(2-chloro-5-fluoro-4-pyriMidinyl)-4-fluoro-2-Methyl-1-(1-Methylethy

6-(2-Chloro-5-fluoro-4-pyrimidinyl)-4-fluoro-1-isopropyl-2-methylbenzimidazole

Abemaciclib Impurity 3

6-(2-chloro-5-fluoro-4-pyrimidinyl)-4-fluoro-2-methyl-1-(1-m...

6-(2-Chloro-5-fluoro-4-pyrimidinyl)-4-fluoro-2-meth yl-1-(1-methylethy)-LH-benzimidazol

Abemaciclib Impurity N3

6-(2-chloro-5-fluoropyrimidin-4-yl)-4-fluoro-1-isopropyl-2-methyl-1H-benzimidazole

Abemaciclib impurity A

1231930-42-9

231930-42-9