1H-BenziMidazole, 4-fluoro-2-Methyl-1-(1-Methylethyl)-6-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-

Product Name: 1H-BenziMidazole, 4-fluoro-2-Methyl-1-(1-Methylethyl)-6-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-
CAS No.: 1231930-37-2
Chemical Name: 1H-BenziMidazole, 4-fluoro-2-Methyl-1-(1-Methylethyl)-6-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-
Synonyms: 4-fluoro-1-isopropyl-2-Methyl-6-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-benzo[d]iMidazole;1H-BENZIMIDAZOLE, 4-FLUORO-2-METHYL-1-(1-METHYLETHYL)-6-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN- 2-Y;Abemaciclib Impurity 2;Abemaciclib Impurity N7;intermediate-1(Abemaciclib);4-fluoro-2-methyl-1-(1-methylethyl)-6-(4,4,5,5-tetramethyl-1...;4-Fluoro-1-isopropyl-2-methylbenzimidazole-6-boronic Acid Pinacol Ester;(4-FLUORO-1-ISOPROPYL-2-METHYL-1H-BENZO[D]IMIDAZOL-6-YL)BORONIC ACID PINACOL ESTER;4-fluoro-2-methyl-1-propan-2-yl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzimidazole;4-fluoro-2-methyl-1-(propan-2-yl)-6-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-1,3-benzodiazole
CBNumber: CB92668465
Molecular Formula: C17H24BFN2O2
Formula Weight: 318.19
MOL File: 1231930-37-2.mol

More

Less

1H-BenziMidazole, 4-fluoro-2-Methyl-1-(1-Methylethyl)-6-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)- Property

Boiling point:: 442.7±30.0 °C(Predicted)
Density: 1.12±0.1 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: 4.32±0.10(Predicted)
Appearance: Off-white to yellow Solid
InChI: InChI=1S/C17H24BFN2O2/c1-10(2)21-11(3)20-15-13(19)8-12(9-14(15)21)18-22-16(4,5)17(6,7)23-18/h8-10H,1-7H3
InChIKey: HUSPISQCNSLJSR-UHFFFAOYSA-N
SMILES: C1(C)N(C(C)C)C2=CC(B3OC(C)(C)C(C)(C)O3)=CC(F)=C2N=1

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

TRC

Product number: F592415
Product name: 4-Fluoro-1-isopropyl-2-methyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-benzo[d]imidazole
Packaging: 100mg
Price: $155
Updated: 2021/12/16

Synthonix

Product number: F17802
Product name: 4-Fluoro-1-isopropyl-2-methyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-benzo[d]imidazole
Purity: 97%
Packaging: 250mg
Price: $80
Updated: 2021/12/16

ChemScene

Product number: CS-M2090
Product name: 1H-Benzimidazole,4-fluoro-2-methyl-1-(1-methylethyl)-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-
Packaging: 100mg
Price: $93
Updated: 2021/12/16

Synthonix

Product number: F17802
Product name: 4-Fluoro-1-isopropyl-2-methyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-benzo[d]imidazole
Purity: 97%
Packaging: 100mg
Price: $50
Updated: 2021/12/16

Synthonix

Product number: F17802
Product name: 4-Fluoro-1-isopropyl-2-methyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-benzo[d]imidazole
Purity: 97%
Packaging: 5g
Price: $520
Updated: 2021/12/16

More

Less

1H-BenziMidazole, 4-fluoro-2-Methyl-1-(1-Methylethyl)-6-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)- Chemical Properties,Usage,Production

Synthesis

1231930-33-8

73183-34-3

1231930-37-2

The general procedure for the synthesis of 4-fluoro-1-isopropyl-2-methyl-6-boronic acid pinacol ester-based-1H-benzo[d]imidazole from 6-bromo-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole and bis(pinacolato)diboron was carried out as follows: in a 500 mL single-necked flask, DMSO (100 mL), followed by sequential addition of 6-bromo-4-fluoro-1- isopropyl-2-methyl-1H-benzo[D]imidazole (20.0 g, 73.80 mmol), bis(pinacolato)diboron (27.6 g, 108.69 mmol), tricyclohexylphosphine (3.53 g, 12.61 mmol) and potassium acetate (21.3 g, 217.38 mmol) were added sequentially. After rapid addition of palladium acetate (1.5 g), the reaction flask was protected by passing nitrogen into the flask and subsequently heated to 90 °C under nitrogen atmosphere. After 3 hours of reaction, the reaction flask was cooled to room temperature and the reaction mixture was poured into 700 mL of water, stirred thoroughly and filtered under reduced pressure. The filter cake was washed twice with 100 mL of water and dried to give a light brown solid. The crude product was pulped with 50 mL of petroleum ether and 10 mL of ethyl acetate for 10 min, and was vacuum filtered to give a white solid (18.8 g, 80.3% yield).

References

[1] Patent: CN107266421, 2017, A. Location in patent: Paragraph 0042; 0043; 0050; 0051
[2] Patent: CN104910137, 2017, B. Location in patent: Paragraph 0213; 0220-0222
[3] Patent: EP3091008, 2016, A1. Location in patent: Paragraph 0177; 0178
[4] Patent: US2010/160340, 2010, A1. Location in patent: Page/Page column 10
[5] Patent: WO2015/130540, 2015, A1. Location in patent: Page/Page column 22

1H-BenziMidazole, 4-fluoro-2-Methyl-1-(1-Methylethyl)-6-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)- Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

1H-BenziMidazole, 4-fluoro-2-Methyl-1-(1-Methylethyl)-6-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)- Suppliers

China 156 India 5 United Kingdom 1 United States 3 Global 165

Hangzhou Chemtrue Bio-Tech Co.,Ltd.

Tel: 0571-86828652 18857119830
Fax: 0571-83522824
Email: sales@chemtrue-bio.com
Country: China
ProdList: 252
Advantage: 58

Haohong (Qihe) Medical Technology Co., LTD

Tel: 0534-2152677 18660163165
Email: sale@inyelchem.com
Country: China
ProdList: 264
Advantage: 58

ChengDu TongChuangYuan Pharmaceutical Co.Ltd

Tel: 28-83379370 13880556291
Fax: 028-87747383
Email: tcy@tcypharm.com
Country: China
ProdList: 510
Advantage: 57

Tetranov Biopharm

Tel: 13526569071
Email: sales@leadmedpharm.com
Country: China
ProdList: 7892
Advantage: 64

WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd.

Tel: 17702719238 18971495150;
Email: sales@sun-shinechem.com
Country: China
ProdList: 1077
Advantage: 64

Nanjing Chemlin Chemical Co., Ltd

Tel: 025-83697070
Fax: +86-25-83453306
Email: info@chemlin.com.cn
Country: China
ProdList: 15883
Advantage: 64

Shanghai Topbiochem Technology Co., Ltd

Tel: 021-58170097
Email: info@topbiochem.com
Country: China
ProdList: 9510
Advantage: 58

SHANGHAI YINGRUI CHEMICAL TECHNOLOGY CO.,LTD.

Tel: 21-33585366 13311639313
Fax: +86-21-34979012
Email: sales@shyrchem.com
Country: China
ProdList: 806
Advantage: 55

Haoyuan Chemexpress Co., Ltd.

Tel: 021-58950125
Fax: (86) 21-58955996
Email: info@chemexpress.com
Country: China
ProdList: 7552
Advantage: 61

Chengdu D-innovation Pharmaceutical Co.，LTD

Tel: 028-85105512 17802830247
Email: baozuqiang@d-innovation.com
Country: China
ProdList: 60
Advantage: 55

More

Less

View Lastest Price from 1H-BenziMidazole, 4-fluoro-2-Methyl-1-(1-Methylethyl)-6-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)- manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: 4-fluoro-1-isopropyl-2-methyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-benzo[d]imidazole 1231930-37-2
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-10-08

Henan Fengda Chemical Co., Ltd

Product: 1H-BenziMidazole, 4-fluoro-2-Methyl-1-(1-Methylethyl)-6-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)- 1231930-37-2
Price: US $5.00-0.10/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-04-10

Career Henan Chemical Co

Product: 1H-BenziMidazole, 6-(2-chloro-5-fluoro-4-pyriMidinyl)-4-fluoro-2-Methyl-1-(1-Methylethyl)- 1231930-37-2
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 100KG
Release date: 2018-08-09

1231930-37-2, 1H-BenziMidazole, 4-fluoro-2-Methyl-1-(1-Methylethyl)-6-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-Related Search:

6-Bromo-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole 2-bromo-8-fluoro-4,5-dihydro-1H-azepino[5,4,3-cd]indol-6(3H)-one PF-01367338 5-((4-Ethylpiperazin-1-yl)methyl)pyridin-2-amine 4-(8-fluoro-6-oxo-3,4,5,6-tetrahydro-1H-azepino[5,4,3-cd]indol-2-yl)benzaldehyde 1H-BenziMidazole, 6-(2-chloro-5-fluoro-4-pyriMidinyl)-4-fluoro-2-Methyl-1-(1-Methylethyl)-

1H-BenziMidazole, 4-fluoro-2-Methyl-1-(1-Methylethyl)-6-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-

4-fluoro-1-isopropyl-2-Methyl-6-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-benzo[d]iMidazole

1H-BENZIMIDAZOLE, 4-FLUORO-2-METHYL-1-(1-METHYLETHYL)-6-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN- 2-Y

1H-BenziMidazole, 4-fluoro-2-Methyl-1-(1-Methylethyl)-6-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)- 4-fluoro-1-isopropyl-2-Methyl-6-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-benzo[d]iMidazole intermediate-1(Abemaciclib)

4-Fluoro-2-methyl-1-(1-methylethyl)-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-benzimidazole

(4-FLUORO-1-ISOPROPYL-2-METHYL-1H-BENZO[D]IMIDAZOL-6-YL)BORONIC ACID PINACOL ESTER

4-fluoro-2-methyl-1-(propan-2-yl)-6-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-1,3-benzodiazole

intermediate-1(Abemaciclib)

4-fluoro-2-methyl-1-propan-2-yl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzimidazole

Abemaciclib Impurity 2

4-fluoro-1-isopropyl-2-methyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolane-2-yl)-1H-benzo[d]imidazole

4-FLUORO-1-ISOPROPYL-2-METHYL-6-(4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLAN-2-YL)-1H-BENZOIMIDAZOLE

1H-BenziMidazole, 4-fluoro-2-Methyl-1-(1-Methylethyl)-6-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)- ISO 9001：2015 REACH

4-fluoro-2-methyl-1-(1-methylethyl)-6-(4,4,5,5-tetramethyl-1...

4-Fluoro-2-methyl-1-(1-methylethyl)-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-benzodimidazole

4-Fluoro-1-isopropyl-2-methylbenzimidazole-6-boronic Acid Pinacol Ester

4-Fluoro-2-methyl-1-(propan-2-yl)-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-benzimidazole

4-Fluoro-1-isopropyl-2-methyl-6-(4,4.5.5-tetrameth 1-1,3,2-dioxaborolan-2-yl)-1H-benzofdlimidazole

4-Fluoro-1-isopropyl-2-methyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-benzo[d]imidazole - [F17802]

Abemaciclib Impurity N7

1231930-37-2

C17H24BFN2O2