5-((4-Ethylpiperazin-1-yl)methyl)pyridin-2-amine
Physical Form- Product Name
- 5-((4-Ethylpiperazin-1-yl)methyl)pyridin-2-amine
- CAS No.
- 1180132-17-5
- Chemical Name
- 5-((4-Ethylpiperazin-1-yl)methyl)pyridin-2-amine
- Synonyms
- Abemaciclib Impurity 4;LY2835219 Intermediate 1;5-[(4-ethyl-1-piperazinyl)methyl]-2-pyridin;5-((4-Ethylpiperazin-1-y)methyDpyridin-2-amine;5-((4-ethylpiperazin-1-yl)methyl)pyridin-2-amin;-((4-Ethylpiperazin-1-yl)Methyl)pyridin-2-aMine;5-((4-Ethylpiperazin-1-yl)methyl)pyridin-2-amine;5-[(4-Ethyl-1-piperazinyl)methyl]-2-pyridinamine;2-Amino-5-[(4-ethyl-1-piperazinyl)methyl]pyridine;5-((4-ethylpiperazin-1-yl)methyl)pyridine-2-amine
- CBNumber
- CB72500105
- Molecular Formula
- C12H20N4
- Formula Weight
- 220.31
- MOL File
- 1180132-17-5.mol
5-((4-Ethylpiperazin-1-yl)methyl)pyridin-2-amine Property
- Boiling point:
- 362℃
- Density
- 1.101
- Flash point:
- 173℃
- storage temp.
- 2-8°C(protect from light)
- pka
- 7.71±0.10(Predicted)
- Appearance
- White to yellow Solid
- InChI
- InChI=1S/C12H20N4/c1-2-15-5-7-16(8-6-15)10-11-3-4-12(13)14-9-11/h3-4,9H,2,5-8,10H2,1H3,(H2,13,14)
- InChIKey
- MNJBMPQTXVZMFZ-UHFFFAOYSA-N
- SMILES
- C1(N)=NC=C(CN2CCN(CC)CC2)C=C1
Safety
- HS Code
- 2933599590
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H318Causes serious eye damage
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P310Immediately call a POISON CENTER or doctor/physician.
P330Rinse mouth.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- E926858
- Product name
- 5-((4-Ethylpiperazin-1-yl)methyl)pyridin-2-amine
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- E926858
- Product name
- 5-((4-Ethylpiperazin-1-yl)methyl)pyridin-2-amine
- Packaging
- 500mg
- Price
- $155
- Updated
- 2021/12/16
- Product number
- 2951AA
- Product name
- 5-((4-Ethylpiperazin-1-yl)methyl)pyridin-2-amine
- Packaging
- 5g
- Price
- $195
- Updated
- 2021/12/16
- Product number
- OR471684
- Product name
- 2-Amino-5-[(4-ethyl-1-piperazinyl)methyl]pyridine
- Packaging
- 5g
- Price
- $226
- Updated
- 2021/12/16
- Product number
- 3H30-1-KV
- Product name
- 2-Amino-5-[(4-ethyl-1-piperazinyl)methyl]pyridine
- Purity
- 95%
- Packaging
- 5G
- Price
- $268
- Updated
- 2021/12/16
5-((4-Ethylpiperazin-1-yl)methyl)pyridin-2-amine Chemical Properties,Usage,Production
Physical Form
Solid
Uses
5-((4-Ethylpiperazin-1-yl)methyl)pyridin-2-amine is a useful research chemical.
Flammability and Explosibility
Not classified
Synthesis
121-44-8
156973-09-0
1180132-17-5
To a 500 mL four-necked round-bottomed flask equipped with a thermometer and condenser tube were added 100 g of 1,2-dichloroethane, 12.5 g (0.1 mol) of 5-(aminomethyl)pyridin-2-amine (IV) and 30.0 g of potassium carbonate. A solution consisting of 25.0 g (0.15 mol) N,N-diethylethylamine and 20 g of 1,2-dichloroethane was added slowly and dropwise over a period of about 2 hours at 30 to 35 °C. The reaction temperature was maintained at 30~35°C and stirring was continued for 6 hours. After completion of the reaction, it was cooled to 20~25°C and layered. The aqueous layer was extracted twice with 1,2-dichloroethane at 20 g. The organic phases were combined and the 1,2-dichloroethane was removed by distillation. To the residue was added 75 g of methyl tert-butyl ether and 0.5 g of activated charcoal and stirred at 80~82°C for 1 hr. After hot filtration, the filtrate was cooled to 0~5°C for crystallization, filtered and dried to afford 18.2 g of 5-((4-ethylpiperazin-1-yl)methyl)pyridin-2-amine as a white solid in 82.7% yield and 99.3% purity of the liquid phase.
References
[1] Patent: CN107337634, 2017, A. Location in patent: Paragraph 0040; 0053; 0054; 0057; 0058; 0061; 0062
5-((4-Ethylpiperazin-1-yl)methyl)pyridin-2-amine Preparation Products And Raw materials
Raw materials
Preparation Products
5-((4-Ethylpiperazin-1-yl)methyl)pyridin-2-amine Suppliers
- Tel
- 021-31261262/ 49 (0)17662837245
- Fax
- (0)21-33250524
- sales@novochemy.com
- Country
- Germany
- ProdList
- 6328
- Advantage
- 58
View Lastest Price from 5-((4-Ethylpiperazin-1-yl)methyl)pyridin-2-amine manufacturers
- Product
- 5-((4-ethylpiperazin-1-yl)methyl)pyridine-2-amine 1180132-17-5
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 1
- Release date
- 2025-08-28
- Product
- 5-((4-Ethylpiperazin-1-yl)methyl)pyridin-2-amine 1180132-17-5
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1000kg
- Release date
- 2025-06-10
- Product
- 5-((4-Ethylpiperazin-1-yl)methyl)pyridin-2-amine 1180132-17-5
- Price
- US $10.00/g
- Min. Order
- 10g
- Purity
- 0.99
- Supply Ability
- 1ton
- Release date
- 2025-05-14