ChemicalBook > CAS DataBase List > P 22077

P 22077

Product Name
P 22077
CAS No.
1247819-59-5
Chemical Name
P 22077
Synonyms
P 22077;CS-1115;P 22077; P-22077;P 22077 USP/EP/BP;USP7/USP47 Inhibitor, P 22077;1-(5-(2,4-difluorophenylthio)-4-nitrothiophen-2-yl)ethanone;1-[5-[(2,4-Difluorophenyl)thio]-4-n-itro-2-thienyl]-ethanone;1-[5-(2,4-difluorophenyl)sulfanyl-4-nitro-2-thienyl]ethanone;Ethanone, 1-[5-[(2,4-difluorophenyl)thio]-4-nitro-2-thienyl]-;1-[5-(2,4-Difluoro-phenylsulfanyl)-4-nitro-thiophen-2-yl]-ethanone
CBNumber
CB02668437
Molecular Formula
C12H7F2NO3S2
Formula Weight
315.32
MOL File
1247819-59-5.mol
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P 22077 Property

Melting point:
146 - 148°C
Boiling point:
395.4±42.0 °C(Predicted)
Density 
1.53±0.1 g/cm3(Predicted)
storage temp. 
-20°C
solubility 
Soluble in DMSO (up to 25 mg/ml)
form 
solid
color 
Off-white
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H302Harmful if swallowed

H372Causes damage to organs through prolonged or repeated exposure

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P273Avoid release to the environment.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Tocris
Product number
4485
Product name
P22077
Purity
≥99%(HPLC)
Packaging
10
Price
$201
Updated
2021/12/16
Tocris
Product number
4485
Product name
P22077
Purity
≥99%(HPLC)
Packaging
50
Price
$817
Updated
2021/12/16
TRC
Product number
P122470
Product name
P22077
Packaging
50mg
Price
$360
Updated
2021/12/16
Usbiological
Product number
256138
Product name
P 22077
Packaging
10mg
Price
$446
Updated
2021/12/16
ApexBio Technology
Product number
A8198
Product name
P22077
Packaging
10mg
Price
$78
Updated
2021/12/16
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P 22077 Chemical Properties,Usage,Production

Description

P22077 (1247819-59-5) is a selective (tested against 23 other DUBs) inhibitor of USP7 (IC50?= 8 μM) and the closely related USP47.1,2?It destabilizes claspin, a scaffolding protein involved in regulating Chk1 kinase, a DNA damage response enzyme.2?P22077 inhibits neuroblastoma growth?via?induction of p53-mediated apoptosis.3?N-Myc was destabilized by P22077 inhibition of USP7 in human neuroblastoma cells.4?It was able to stabilize p53 levels in conjunction with an Mdm2 inhibitor (Nutlin-3,?Cat# 10-1350)?in HCT116 colorectal carcinoma cells.5

Uses

P22077 is an analog of the ubiquitin-specific protease (USP7) inhibitor P5091. It inhibits USP7, as well.

storage

Store at +4°C

References

1) Tian?et al. (2011),?Characterization of Selective Ubiquitin and Ubiquitin-like Protease Inhibitors Using a Fluorescence-Based Multiplex Assay Format; Assay Drug Dev. Technol.?9?165 2) Altun?et al.?(2011),?Activity-based chemical proteomics accelerates inhibitor development for deubiquitinylating enzymes; Chem. Biol.?18?1401 3) Fan?et al.?(2013),?USP7 inhibitor P22077 inhibits neuroblastoma growth via inducing p53-mediated apoptosis;?Cell Death Dis.?4?e867 4) Tavana?et al.?(2016),?HAUSP deubiquitinates and stabilizes M-Myc in neuroblastoma; Nat. Med.?22?1180 5) Tavana?et al.?(2018),?Targeting HAUSP in both p53 wildtype and p53-mutant tumors; Cell Cycle?17?823

P 22077 Preparation Products And Raw materials

Raw materials

Preparation Products

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P 22077 Suppliers

China 73 China Hong Kong 1 India 1 United Kingdom 2 United States 18 Global 95
MedChemexpress LLC
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Target molecule Corp.
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Musechem
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TargetMol Chemicals Inc.
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+1-781-999-5354 +1-00000000000
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marketing@targetmol.com
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InvivoChem
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Cckinase, Inc.
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+1 (732)236-3202
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sales@cckinase.com
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BOC Sciences
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Aladdin Scientific
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ApexBio Technology
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Focus Biomolecules
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United States Biological
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Creative Enzymes
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Matrix Scientific
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1247819-59-5, P 22077Related Search:

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  • P 22077
  • 1-(5-(2,4-difluorophenylthio)-4-nitrothiophen-2-yl)ethanone
  • 1-[5-[(2,4-Difluorophenyl)thio]-4-n-itro-2-thienyl]-ethanone
  • Ethanone, 1-[5-[(2,4-difluorophenyl)thio]-4-nitro-2-thienyl]-
  • 1-[5-[(2,4-Difluorophenyl)thio]-4-nitro-2-thienyl]ethanone P 22077
  • P 22077 1-[5-[(2,4-Difluorophenyl)thio]-4-nitro-2-thienyl]ethanone
  • 1-[5-(2,4-Difluoro-phenylsulfanyl)-4-nitro-thiophen-2-yl]-ethanone
  • CS-1115
  • P 22077; P-22077
  • USP7/USP47 Inhibitor, P 22077
  • P 22077 USP/EP/BP
  • 1-[5-(2,4-difluorophenyl)sulfanyl-4-nitro-2-thienyl]ethanone
  • 1247819-59-5
  • C12H7F2NO3S2
  • Inhibitors