AZD 9668
- Product Name
- AZD 9668
- CAS No.
- 848141-11-7
- Chemical Name
- AZD 9668
- Synonyms
- AZD9668;CS-1060;AZD-9668;AZD 9668;MPH-966);Avelestat;Alvelestat;Cavosonstat;Alvelestat-13C,d3;Avelestat (AZD9668)
- CBNumber
- CB02668624
- Molecular Formula
- C25H22F3N5O4S
- Formula Weight
- 545.53
- MOL File
- 848141-11-7.mol
AZD 9668 Property
- Melting point:
- 207-209°C
- Boiling point:
- 780.4±60.0 °C(Predicted)
- Density
- 1.42±0.1 g/cm3(Predicted)
- storage temp.
- -20°C Freezer
- solubility
- DMSO (Slightly), Methanol (Slightly)
- pka
- 11.00±0.20(Predicted)
- form
- Solid
- color
- White
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 26083
- Product name
- AZD 9668
- Packaging
- 5mg
- Price
- $109
- Updated
- 2024/03/01
- Product number
- 26083
- Product name
- AZD 9668
- Packaging
- 25mg
- Price
- $426
- Updated
- 2024/03/01
- Product number
- 26083
- Product name
- AZD 9668
- Packaging
- 1mg
- Price
- $44
- Updated
- 2024/03/01
- Product number
- 26083
- Product name
- AZD 9668
- Packaging
- 10mg
- Price
- $193
- Updated
- 2024/03/01
- Product number
- A794660
- Product name
- Avelestat
- Packaging
- 25mg
- Price
- $475
- Updated
- 2021/12/16
AZD 9668 Chemical Properties,Usage,Production
Description
AZD 9668 is an orally bioavailable inhibitor of neutrophil elastase (IC50 = 12 nM for the human enzyme). It is greater than 600-fold selective for neutrophil elastase over other serine proteases, including human proteinase-3 and cathepsin G, bovine trypsin and chymotrypsin, and porcine pancreatic elastase. AZD 9668 inhibits neutrophil elastase activity in zymosan-stimulated isolated whole blood and in cell-associated assays (IC50s = 46 and 48 nM, respectively). It decreases the number of neutrophils in bronchoalveolar lavage fluid (BALF) in a mouse model of smoke-induced airway inflammation when administered at a dose of 6 mg/kg. AZD 9668 also prevents airspace enlargement and small airway remodeling in a guinea pig model of chronic smoke-induced inflammation and emphysema.
Uses
Avelstat inhibits plasma neutrophil elastase (NE) activity in zymosan-stimulated whole blood, and also inhibits NE activity on the surface of stimulated polymorphonuclear cells and in the supernatant of primed, stimulated cells.
target
NE
References
[1] stevens t, ekholm k, gränse m, et al. azd9668: pharmacological characterization of a novel oral inhibitor of neutrophil elastase. journal of pharmacology and experimental therapeutics, 2011, 339(1): 313-320.
AZD 9668 Preparation Products And Raw materials
Raw materials
Preparation Products
AZD 9668 Suppliers
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- Fax
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View Lastest Price from AZD 9668 manufacturers
- Product
- Alvelestat 848141-11-7
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10
- Product
- Alvelestat 848141-11-7
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-09
- Product
- AZD 9668 848141-11-7
- Price
- US $9.80/KG
- Min. Order
- 1g
- Purity
- ≥99%
- Supply Ability
- 100kg
- Release date
- 2020-01-12