Carteolol
- Product Name
- Carteolol
- CAS No.
- 51781-06-7
- Chemical Name
- Carteolol
- Synonyms
- C06874;Carteolol;dl-Carteolol;Carteolol USP/EP/BP;Carteolol Impurities1808;Carteolol (base and/or unspecified salts);5-[3-(tert-Butylamino)-2-hydroxypropoxy]-3,4-dihydrocarbostyril;5-(2-Hydroxy-3-tert-butylaminopropoxy)-3,4-dihydro-2(1H)-quinolone;5-[3-(tert-Butylamino)-2-hydroxypropoxy]-3,4-dihydroquinolin-2(1H)-one;5-[3-(tert-Butylamino)-2-hydroxypropoxy]-3,4-dihydro-1H-quinolin-2-one
- CBNumber
- CB0268673
- Molecular Formula
- C16H24N2O3
- Formula Weight
- 292.37
- MOL File
- 51781-06-7.mol
Carteolol Property
- Boiling point:
- 434.3°C (rough estimate)
- Density
- 1.0574 (rough estimate)
- refractive index
- 1.5800 (estimate)
- pka
- 13.84±0.20(Predicted)
- CAS DataBase Reference
- 51781-06-7
N-Bromosuccinimide Price
- Product number
- API0007227
- Product name
- CARTEOLOL
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $885.15
- Updated
- 2021/12/16
- Product number
- API0007227
- Product name
- CARTEOLOL
- Purity
- 95.00%
- Packaging
- 10G
- Price
- $1334.03
- Updated
- 2021/12/16
- Product number
- 1591B
- Product name
- Carteolol
- Packaging
- 5mg
- Price
- $49
- Updated
- 2021/12/16
- Product number
- 1591B
- Product name
- Carteolol
- Packaging
- 10mg
- Price
- $79
- Updated
- 2021/12/16
- Product number
- 1591B
- Product name
- Carteolol
- Packaging
- 20mg
- Price
- $109
- Updated
- 2021/12/16
Carteolol Chemical Properties,Usage,Production
Originator
Mikelan,Otsuka,Japan,1981
Uses
Antiadrenergic (β-receptor).
Definition
ChEBI: Carteolol is a quinolone and a secondary alcohol. It has a role as a beta-adrenergic antagonist, an antihypertensive agent, an antiglaucoma drug, an anti-arrhythmia drug and a sympatholytic agent. It is a conjugate base of a carteolol(1+).
Manufacturing Process
A mixture of 1.63 g of 5-hydroxy-3,4-dihydrocarbostyril, 2.5 g of
epibromohydrin and 2 drops of piperidine was heated at a temperature of
95°C to 100°C for a period of 4 hours with stirring. The reaction mixture was
then concentrated to dryness under reduced pressure and the residue was
recrystallized from acetone to obtain 1.2 g of 5-(2,3-epoxy)propoxy-3,4-
dihydrocarbostyril as a colorless powder having a melting point of 172°C to
173°C.
A mixture of 0.75 g of 5-(2,3-epoxy)propoxy-3,4-dihydrocarbostyril, 1.0 g of
tert-butylamine and 25 ml of ethanol was stirred at a temperature of from
50°C to 55°C for a period of 4 hours. Ethanol and unreacted tert-butylamine
were distilled off under reduced pressure and the resulting residue was
dissolved in acetone.
brand name
Cartrol (Abbott); Ocupress (Novartis).
Therapeutic Function
Beta-adrenergic blocker
Contact allergens
Carteolol was implicated in allergic contact dermatitis due to beta-blockers agents in eye-drops. It seems that this molecule can be safely used in some patients with hypersensitivity to other topical beta-blockers agents.
Veterinary Drugs and Treatments
Carteolol HCl is a nonspecific beta adrenergic blocking agent and it reduces aqueous humor production by decreasing cyclic-AMP synthesis in the ciliary body. Carteolol is a suitable substitute for timolol maleate or any of the other beta blocking agents although it is rarely used in veterinary medicine. In humans, similar IOP reducing effects have been shown for all members of this class. Substitutes are necessary when one particular product induces topical irritation upon application. As noted above, beta blocking agents seem to be particularly useful in the management of primary glaucoma in cats.
Metabolism
Carteolol (Cartrol) is a long-acting -blocker that is suitable for dosing once per day. It is almost completely absorbed and exhibits about 30% binding to plasma proteins. Unlike many -blockers, carteolol is not extensively metabolized. Up to
Carteolol Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Carteolol manufacturers
- Product
- Carteolol 51781-06-7
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.9%
- Supply Ability
- 100 Tons min
- Release date
- 2021-08-11