ChemicalBook > CAS DataBase List > YM 2447690

YM 2447690

Product Name
YM 2447690
CAS No.
837424-39-2
Chemical Name
YM 2447690
Synonyms
YM 244769;YM 2447690;YM-244769 hydrochloride;N-[(3-Aminophenyl)methyl]-6-[4-[(3-fluorophenyl)methoxy]phenoxy]-3-pyridinecarboxamide dihydrochloride
CBNumber
CB02701747
Molecular Formula
C27H24ClFN2O3
Formula Weight
478.9424632
MOL File
837424-39-2.mol
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YM 2447690 Property

storage temp. 
Desiccate at RT
solubility 
Soluble to 100 mM in DMSO
form 
Powder
color 
Off-white to light yellow
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Tocris
Product number
4544
Product name
YM244769
Purity
≥99%(HPLC)
Packaging
10
Price
$191
Updated
2021/12/16
Tocris
Product number
4544
Product name
YM244769
Purity
≥99%(HPLC)
Packaging
50
Price
$823
Updated
2021/12/16
Usbiological
Product number
257147
Product name
YM 244769
Packaging
10mg
Price
$466
Updated
2021/12/16
TRC
Product number
Y100565
Product name
YM2447690
Packaging
50mg
Price
$550
Updated
2021/12/16
Medical Isotopes, Inc.
Product number
49253
Product name
YM2447690
Packaging
10mg
Price
$640
Updated
2021/12/16
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YM 2447690 Chemical Properties,Usage,Production

Uses

YM 2447690 is a sodium-calcium exchanger (NCX) inhibitor used for the prevention and treatment of reperfusion arrhythmias, myocardial contracture and necrosis. This compound has neuroprotective properties.

in vivo

YM-244769 (0.1-1 mg/kg; p.o.; once) exhibits dose-dependently natriuretic action in mice and significantly increased urinary excretion of Ca2+ as well as Ca2+/Cr ratio[2].

Animal Model:Wild-type C57BL/6J mice and NCX-KO mice[2]
Dosage:0.1, 0.3 and 1 mg/kg
Administration:Oral administration, once
Result:Caused a dose-dependent increase (up to approximately 200%) in urine volume and urinary excretion of electrolytes (Na+, K+ and Cl-). Natriuretic actions were equivalently observed in NCX1-KO and WT, but disappeared in NCX2-KO and double KO.

YM 2447690 Preparation Products And Raw materials

Raw materials

Preparation Products

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YM 2447690 Suppliers

Canada 1 China 20 India 1 United Kingdom 1 United States 5 USA 1 Global 29
J & K SCIENTIFIC LTD.
Tel
18210857532; 18210857532
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
EMMX Biotechnology LLC
Tel
888-539-0666
Fax
888-539-0666
Email
info@emmx.com
Country
United States
ProdList
8447
Advantage
60
Shenzhen Polymeri Biochemical Technology Co., Ltd.
Tel
+86-400-002-6226 +86-13028896684;
Email
sales@rrkchem.com
Country
China
ProdList
57422
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32435
Advantage
58
Jinan ponder chemical co. LTD
Tel
0531-0000
Email
thinklifescience@163.com
Country
China
ProdList
19689
Advantage
58
MedBioPharmaceutical Technology Inc
Tel
021-69568360 18916172912
Email
order@med-bio.cn
Country
China
ProdList
8140
Advantage
58
TargetMol Chemicals Inc.
Tel
4008200310
Email
marketing@tsbiochem.com
Country
China
ProdList
24961
Advantage
58
Suzhou Zhixin Biotechnology Co., Ltd.
Tel
0512-65118909 18100677375
Email
sales@szzxbio.com
Country
China
ProdList
2993
Advantage
58
Shanghai Yifei Biotechnology Co. , Ltd.
Tel
021-65675885 18964387627
Email
customer_service@efebio.com
Country
China
ProdList
11973
Advantage
58
Biosynth Biological Technology (Suzhou) Co Ltd
Tel
51288865780
Email
sales@biosynth.com
Country
China
ProdList
6051
Advantage
58

837424-39-2, YM 2447690Related Search:

3-Pyridinecarboxamide, N-[(3-aminophenyl)methyl]-6-[4-[(3-fluorophenyl)methoxy]phenoxy]- YM-244769 dihydrochloride

  • N-[(3-Aminophenyl)methyl]-6-[4-[(3-fluorophenyl)methoxy]phenoxy]-3-pyridinecarboxamide dihydrochloride
  • YM 2447690
  • YM 244769
  • YM-244769 hydrochloride
  • 837424-39-2
  • C26H22FN3O32HCl