Oxobutanedioic acid
- Product Name
- Oxobutanedioic acid
- CAS No.
- 328-42-7
- Chemical Name
- Oxobutanedioic acid
- Synonyms
- OXALOACETIC ACID;OXALACETIC ACID;2-OXOSUCCINIC ACID;OAA;oxalacetic;NSC 77688;NSC 284205;2-OXOSUCCINIC;OXLACETIC ACID;oxaloaceticaci
- CBNumber
- CB0271682
- Molecular Formula
- C4H4O5
- Formula Weight
- 132.07
- MOL File
- 328-42-7.mol
Oxobutanedioic acid Property
- Melting point:
- 161 °C (dec.)(lit.)
- Boiling point:
- 163.94°C (rough estimate)
- Density
- 1.3067 (rough estimate)
- vapor pressure
- 0.003Pa at 20℃
- refractive index
- 1.4000 (estimate)
- Flash point:
- 88°C
- storage temp.
- -20°C
- solubility
- H2O: 100 mg/mL
- form
- powder
- pka
- 2.22(at 25℃)
- color
- White to off-white
- PH
- 3.05(1 mM solution);2.29(10 mM solution);1.68(100 mM solution)
- Water Solubility
- soluble
- Merck
- 14,6909
- BRN
- 1705475
- Stability:
- Stable. Incompatible with strong oxidizing agents. Keep refrigerated.
- LogP
- -1.04 at 20℃
- CAS DataBase Reference
- 328-42-7(CAS DataBase Reference)
- NIST Chemistry Reference
- Oxalacetic acid(328-42-7)
- EPA Substance Registry System
- Oxalacetic acetic (328-42-7)
Safety
- Hazard Codes
- C
- Risk Statements
- 34
- Safety Statements
- 26-36/37/39-45
- RIDADR
- UN 3261 8/PG 2
- WGK Germany
- 3
- TSCA
- Yes
- HazardClass
- 8
- PackingGroup
- II
- HS Code
- 29183000
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- O4126
- Product name
- Oxaloacetic acid
- Purity
- ≥97% (HPLC)
- Packaging
- 1g
- Price
- $61.8
- Updated
- 2024/03/01
- Product number
- O0072
- Product name
- Oxalacetic Acid
- Purity
- >97.0%(T)
- Packaging
- 5g
- Price
- $58
- Updated
- 2024/03/01
- Product number
- O0072
- Product name
- Oxalacetic Acid
- Purity
- >97.0%(T)
- Packaging
- 25g
- Price
- $168
- Updated
- 2024/03/01
- Product number
- 015789
- Product name
- Oxalacetic acid, 98+%
- Packaging
- 2g
- Price
- $31.65
- Updated
- 2024/03/01
- Product number
- 015789
- Product name
- Oxalacetic acid, 98+%
- Packaging
- 10g
- Price
- $127
- Updated
- 2023/06/20
Oxobutanedioic acid Chemical Properties,Usage,Production
Description
Oxaloacetic acid is an α-keto acid and a key component of cellular metabolism in its conjugate base form, oxaloacetate. Oxaloacetate reacts with acetyl-coenzyme A (acetyl-CoA; ) and water to form citrate in the first step of the citric acid cycle and is regenerated by oxidation of L-malate in the final step. It is an intermediate in gluconeogenesis that is formed in mitochondria via carboxylation of pyruvate and subsequently decarboxylated and phosphorylated to form phosphoenolpyruvate. It can be converted to aspartate via addition of an amino group from glutamate. Oxaloacetate (30 μmol/min per 100 g for 30 minutes, i.v.) reduces blood glutamate levels, severity of neurological dysfunction, and brain edema in a rat model of closed head injury.
Chemical Properties
off-white crystals
Uses
A four carbon dicarboxylic acid that is an intermediate in the citric acid cycle and glucogenesis. It has been shown to inhibit succinate dehydrogenase.
Uses
Use as a TCA (Krebs cycle) intermediate supplement in hybridoma cell culture applications. Enhances hybridoma growth and productivity.
Uses
Oxaloacetic acid is a substrate for malate dehydrogenase and oxaloacetate decarboxylase. It is an inhibitor of succinic dehydrogenase. It is an intermediate in the citric acid cycle and glucogenesis.
Definition
ChEBI: An oxodicarboxylic acid that is succinic acid bearing a single oxo group.
General Description
Oxaloacetic acid is a dicarboxylic acid. It is an intermediate in the citric acid cycle. It is highly soluble in water and is present ubiquitously. It is produced in the mitochondria by the action of pyruvate carboxylase on pyruvate. Breakdown products of oxaloacetate includes malate, pyruvate and aspartic acid.
Flammability and Explosibility
Not classified
Biological Activity
Oxalacetic acid (Oxaloacetic acid, 2-Oxosuccinic acid, Ketosuccinic acid) is an intermediate of the citric acid cycle, where it reacts with acetyl-CoA to form citrate, catalysed by citrate synthase. It is also involved in gluconeogenesis, urea cycle, glyoxylate cycle, amino acid synthesis, and fatty acid synthesis. Oxaloacetate is also a potent inhibitor of Complex II.
Biochem/physiol Actions
Oxaloacetic acid being an intermediate in the tri carboxylic cycle is central to metabolism. It is part of gluconeogenesis pathway. Mutation in pyruvate carboxylase leads to decreased production of oxaloacetate. It inhibits succinate dehydrogenase and is a key regulator of mitochondrial metabolism.
Purification Methods
Crystallise it from boiling EtOAc, or from hot Me2CO/hot *C6H6. [Beilstein 3 IV 1808.]
Oxobutanedioic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Oxobutanedioic acid manufacturers
- Product
- Oxobutanedioic acid 328-42-7
- Price
- US $75.00-25.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 20ton
- Release date
- 2024-05-28
- Product
- Oxalacetic acid 328-42-7
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 20MT
- Release date
- 2024-11-14
- Product
- Oxobutanedioic acid 328-42-7
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2024-11-15