[(3R)-3-Amino-4-[(3-hexylphenyl)amino]-4-oxobutyl]-phosphonic acid mono(trifluoroacetate)

Product Name: [(3R)-3-Amino-4-[(3-hexylphenyl)amino]-4-oxobutyl]-phosphonic acid mono(trifluoroacetate)
CAS No.: 909725-62-8
Chemical Name: [(3R)-3-Amino-4-[(3-hexylphenyl)amino]-4-oxobutyl]-phosphonic acid mono(trifluoroacetate)
Synonyms: W146;W146 TFA;(R)-3-AMino-(3-hexylphenylaMino)-4-oxobutylphosphonic acid (TFA salt);(R)-3-AMINO-(3-HEXYLPHENYLAMINO)-4-OXOBUTYLPHOSPHONIC ACID (TFA SALT);W146;[(3R)-3-Amino-4-[(3-hexylphenyl)amino]-4-oxobutyl]-phosphonic acid mono(trifluoroacetate)
CBNumber: CB02717540
Molecular Formula: C18H28F3N2O6P
Formula Weight: 456.3936906
MOL File: 909725-62-8.mol

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[(3R)-3-Amino-4-[(3-hexylphenyl)amino]-4-oxobutyl]-phosphonic acid mono(trifluoroacetate) Property

storage temp.: Store at -20°C
solubility: Methanol: 0.1 mg/ml
form: A crystalline solid
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 10009109
Product name: W146 (trifluoroacetate salt)
Purity: ≥95%
Packaging: 500μg
Price: $78
Updated: 2024/03/01

Cayman Chemical

Product number: 10009109
Product name: W146 (trifluoroacetate salt)
Purity: ≥95%
Packaging: 1mg
Price: $146
Updated: 2024/03/01

Cayman Chemical

Product number: 10009109
Product name: W146 (trifluoroacetate salt)
Purity: ≥95%
Packaging: 5mg
Price: $614
Updated: 2024/03/01

Cayman Chemical

Product number: 10009109
Product name: W146 (trifluoroacetate salt)
Purity: ≥95%
Packaging: 10mg
Price: $1071
Updated: 2024/03/01

Tocris

Product number: 3602
Product name: W146
Purity: ≥98%(HPLC)
Packaging: 1
Price: $173
Updated: 2021/12/16

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[(3R)-3-Amino-4-[(3-hexylphenyl)amino]-4-oxobutyl]-phosphonic acid mono(trifluoroacetate) Chemical Properties,Usage,Production

Uses

W146 is a selective antagonists of spingosine-1-phosphate receptor subtype 1.

Biological Activity

W146 acts as an orthosteric antagonist. It is linked to blood lymphopenia and lung edema in mice.

in vivo

W146 (5 mg/kg, ip, prior to AMD3100 administration) pre-treatment shows approximately 8-fold increase of KSL-HSPC mobilization, measured by the CFU-G/M colony forming assays, compared to that in mice treated with AMD3100 alone^[3]
The W146-mediated augmentation of KSL-HSPC mobilization is specific, because pretreatment of mice with W140 is unable to produce any effect on AMD3100-stimulated KSL-HSPC mobilization. Injections of W146, W140, JTE013, or Cay10444 do not alter the basal WBC count in mice^[3].

Animal Model:	Mice (4-6-week-old)^[3] .
Dosage:	5 mg/kg.
Administration:	IP, 1 hour prior to AMD3100 (ADM) administration.
Result:	Significantly increased in KSL-HSPC mobilization compared to that in mice pretreated with dextran followed by AMD3100 administration.

[(3R)-3-Amino-4-[(3-hexylphenyl)amino]-4-oxobutyl]-phosphonic acid mono(trifluoroacetate) Preparation Products And Raw materials

Raw materials

Preparation Products

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[(3R)-3-Amino-4-[(3-hexylphenyl)amino]-4-oxobutyl]-phosphonic acid mono(trifluoroacetate) Suppliers

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909725-62-8, [(3R)-3-Amino-4-[(3-hexylphenyl)amino]-4-oxobutyl]-phosphonic acid mono(trifluoroacetate)Related Search:

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[(3R)-3-Amino-4-[(3-hexylphenyl)amino]-4-oxobutyl]-phosphonic acid mono(trifluoroacetate)

(R)-3-AMino-(3-hexylphenylaMino)-4-oxobutylphosphonic acid (TFA salt)

W146

(R)-3-AMINO-(3-HEXYLPHENYLAMINO)-4-OXOBUTYLPHOSPHONIC ACID (TFA SALT);W146

W146 TFA

909725-62-8

C16H27N2O4PC2HF3O2

C16H27N2O4PCF3COOH