N-(4-AMINOBUTYL)-5-CHLORO-2-NAPHTHALENESULFONAMIDE HYDROCHLORIDE

Product Name: N-(4-AMINOBUTYL)-5-CHLORO-2-NAPHTHALENESULFONAMIDE HYDROCHLORIDE
CAS No.: 88519-57-7
Chemical Name: N-(4-AMINOBUTYL)-5-CHLORO-2-NAPHTHALENESULFONAMIDE HYDROCHLORIDE
Synonyms: W-13;W-13 HYDROCHLORIDE;OMEGA-13 HYDROCHLORIDE;N-(4-AMINOBUTYL)-5-CHLORO-2- &;W-13 HYDROCHLORIDE CALMODULIN ANTAGONIST;N-(4-aminobutyl)-5-chloro-2-*naphthalenesulfonami;W-13, Hydrochloride - CAS 88519-57-7 - Calbiochem;N-(4-AMINOBUTYL)-5-CHLORO-2-NAPHTHALENESULFONAMIDE HCL;4-[(5-chloro-2-naphthalenyl)sulfonylamino]butylammonium;N-(4-Aminohexyl)-5-chloro-2-naphthalenesulfonamide hydrochloride
CBNumber: CB0466031
Molecular Formula: C14H18Cl2N2O2S
Formula Weight: 349.28
MOL File: 88519-57-7.mol

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N-(4-AMINOBUTYL)-5-CHLORO-2-NAPHTHALENESULFONAMIDE HYDROCHLORIDE Property

Melting point:: 241-243°C
storage temp.: room temp
solubility: H₂O: Stock solutions of 5 mM are recommended. These stocks should be stable for up to 6 months when stored at 4°C.soluble
form: powder
color: white
Water Solubility: water: 35mg/mL
CAS DataBase Reference: 88519-57-7(CAS DataBase Reference)

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Safety

Safety Statements: 22-24/25
WGK Germany: 3
HS Code: 2935.90.9500

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0717
Product name: W-13
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $82
Updated: 2025/07/31

Sigma-Aldrich

Product number: 681636-M
Product name: W-13, Hydrochloride
Purity: A cell-permeable and reversible calmodulin antagonist that inhibits myosin light chain kinase (IC₅₀ = 58 µM) and Ca<sup>2+</sup>-calmodulin-dependent phosphodiesterase (IC₅&#83
Packaging: 1 unit
Price: $108
Updated: 2025/07/31

Sigma-Aldrich

Product number: 681636-M
Product name: W-13, Hydrochloride
Packaging: 1mg-m
Price: $114
Updated: 2021/12/16

Sigma-Aldrich

Product number: 681636-M
Product name: W-13, Hydrochloride - CAS 88519-57-7 - Calbiochem
Purity: A cell-permeable and reversible calmodulin antagonist that inhibits myosin light chain kinase (IC?? = 58 μM) and Ca2+-calmodulin-dependent phosphodiesterase (IC?? = 68 μM).
Packaging: 1mg
Price: $114
Updated: 2021/12/16

TCI Chemical

Product number: A2416
Product name: N-(4-Aminobutyl)-5-chloronaphthalene-2-sulfonamide Hydrochloride
Purity: >98.0%(HPLC)(N)
Packaging: 25mg
Price: $48
Updated: 2023/06/20

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N-(4-AMINOBUTYL)-5-CHLORO-2-NAPHTHALENESULFONAMIDE HYDROCHLORIDE Chemical Properties,Usage,Production

Description

W-13 is a naphthalenesulfonamide derivative that acts as a potent antagonist of calmodulin (IC₅₀ = 22 μM) and is widely used to investigate Ca²⁺/calmodulin-regulated enzyme activities.

Chemical Properties

Beige Solid

Uses

W-13 is a naphthalenesulfonamide derivative that acts as a potent antagonist of calmodulin (IC50 = 22 μM) and is widely used to investigate Ca2+/calmodulin-regulated enzyme activities.

Uses

Calmodulin antagonist that binds to calmodulin and inhibits calcium-ion-calmodulin- regulated activities, including phosphodiesterase activation and myosin light chain kinase127, it is widely used to investigate Ca2+/calmodulin-regulated enzyme activities.

Definition

ChEBI: N-(4-aminobutyl)-5-chloronaphthalene-2-sulfonamide hydrochloride is a hydrochloride salt prepared from equimolar amounts of N-(4-aminobutyl)-5-chloronaphthalene-2-sulfonamide and hydrogen chloride. It contains a N-(4-aminobutyl)-5-chloronaphthalene-2-sulfonamide(1+).

Biological Activity

Calmodulin antagonist (inhibits calmodulin activated PDE activity with an IC 50 of 68 μ M). Inhibits growth of tamoxifen-resistant breast cancer cells.

Biochem/physiol Actions

W-13 has also been shown to inhibit the transcytosis of IgA, recycling of transferrin and overall alter the endocytic pathway in Madin-Darby canine kidney cells.

storage

Store at RT

References

[1] N. KATAYAMA. A role for calmodulin in the growth of human hematopoietic progenitor cells.[J]. Blood, 1990, 75 7 1: 1446-1454. DOI: 10.1182/blood.v75.7.1446.bloodjournal7571446
[2] F. TEBAR. Calmodulin regulates intracellular trafficking of epidermal growth factor receptor and the MAPK signaling pathway.[J]. Molecular Biology of the Cell, 2002, 13 6 1: 2057-2068. DOI: 10.1091/mbc.01-12-0571
[3] PARIJAT SENGUPTA. Membrane-permeable calmodulin inhibitors (e.g. W-7/W-13) bind to membranes, changing the electrostatic surface potential: dual effect of W-13 on epidermal growth factor receptor activation.[J]. The Journal of Biological Chemistry, 2007, 282 11: 8474-8486. DOI: 10.1074/jbc.m607211200

N-(4-AMINOBUTYL)-5-CHLORO-2-NAPHTHALENESULFONAMIDE HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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N-(4-AMINOBUTYL)-5-CHLORO-2-NAPHTHALENESULFONAMIDE HYDROCHLORIDE Suppliers

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View Lastest Price from N-(4-AMINOBUTYL)-5-CHLORO-2-NAPHTHALENESULFONAMIDE HYDROCHLORIDE manufacturers

Zhuozhou Wenxi import and Export Co., Ltd

Product: N-(4-AMINOBUTYL)-5-CHLORO-2-NAPHTHALENESULFONAMIDE HYDROCHLORIDE 88519-57-7
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-08-11

88519-57-7, N-(4-AMINOBUTYL)-5-CHLORO-2-NAPHTHALENESULFONAMIDE HYDROCHLORIDERelated Search:

BenzenesulfonaMide, 4-chloro-N-[1-(2-phenylethyl)-2-piperidinylidene]- (S)-3-aMino-4-(3-hexylphenylaMino)-4-oxobutylphosphonic acid (TFA salt) N-[[4-(DIMETHYLAMINO)PHENYL]METHYL]-1,2,3,4-TETRAHYDRO-7-METHOXY-N-[4-(1-METHYLETHYL)PHENYL]-1-NAPHTHALENECARBOXAMIDE HYDROCHLORIDE W-5 HYDROCHLORIDE W123 Exclusive [(3R)-3-Amino-4-[(3-hexylphenyl)amino]-4-oxobutyl]-phosphonic acid mono(trifluoroacetate) Naphthalene Carbon tetrachloride Propylene oxide N-TERT-BUTYL-ALPHA-PHENYLNITRONE N-(4-AMINOBUTYL)-5-CHLORO-1-NAPHTHALENESULFONAMIDE, HYDROCHLORIDE NAPHTHALENE-2-SULFONAMIDE 1-Chloronaphthalene 1,4-Diaminobutane dihydrochloride N-(4-AMINOBUTYL)-2-NAPHTHALENESULFONAMIDE HYDROCHLORIDE N-(4-AMINOBUTYL)-5-CHLORO-2-NAPHTHALENESULFONAMIDE HYDROCHLORIDE

W-13, Hydrochloride - CAS 88519-57-7 - Calbiochem

4-[(5-chloro-2-naphthalenyl)sulfonylamino]butylammonium

N-(4-AMINOBUTYL)-5-CHLORO-2-NAPHTHALENESULFONAMIDE HYDROCHLORIDE

N-(4-AMINOBUTYL)-5-CHLORO-2-NAPHTHALENE SULPHONAMIDE, HYDROCHLORIDE

OMEGA-13 HYDROCHLORIDE

W-13

W-13 HYDROCHLORIDE

N-(4-Aminohexyl)-5-chloro-2-naphthalenesulfonamide hydrochloride

(+)-5-Hydroxy-8-[5-(5-hydroxy-7-methoxy-4-oxo-4H-1-benzopyran-2-yl)-2-methoxyphenyl]-7-methoxy-2-(4-methoxyphenyl)-4H-1-benzopyran-4-one

N-(4-Aminobutyl)-5-chloronaphthalene-2-sulphonamide hydrochloride

N-(4-aminobutyl)-5-chloro-2-*naphthalenesulfonami

N-(4-AMINOBUTYL)-5-CHLORO-2- &

W-13 HYDROCHLORIDE CALMODULIN ANTAGONIST

N-(4-AMINOBUTYL)-5-CHLORO-2-NAPHTHALENESULFONAMIDE HCL

N-(4-AMinobutyl)-5-chloro-2-naphthalenesulfonaMide Monohydrochloride

2-NaphthalenesulfonaMide, N-(4-aMinobutyl)-5-chloro-, Monohydrochloride

<i>N</i>-(4-Aminobutyl)-5-chloronaphthalene-2-sulfonamide Hydrochloride

N-(4-AMinobutyl)-5-chloronaphthalene-2-sulfonaMide Hydrochloride

N-(4-Aminobutyl)-5-chloronaphthalene-2-sulfonamide Hydrochloride &gt

88519-57-7

C14H18Cl2N2O2S

C14H17ClN2O2SHCl

Intracellular Calcium Signaling

Cell Biology

Calcium Antagonists

Cell Signaling and Neuroscience

BioChemical

All Inhibitors

Inhibitors

Protein Kinase Inhibitors and Activators

Calcium signaling

Amines

Aromatics

Sulfur & Selenium Compounds