ChemicalBook > CAS DataBase List > N-(4-AMINOBUTYL)-5-CHLORO-2-NAPHTHALENESULFONAMIDE HYDROCHLORIDE

N-(4-AMINOBUTYL)-5-CHLORO-2-NAPHTHALENESULFONAMIDE HYDROCHLORIDE

Product Name
N-(4-AMINOBUTYL)-5-CHLORO-2-NAPHTHALENESULFONAMIDE HYDROCHLORIDE
CAS No.
88519-57-7
Chemical Name
N-(4-AMINOBUTYL)-5-CHLORO-2-NAPHTHALENESULFONAMIDE HYDROCHLORIDE
Synonyms
W-13;W-13 HYDROCHLORIDE;OMEGA-13 HYDROCHLORIDE;N-(4-AMINOBUTYL)-5-CHLORO-2- &;W-13 HYDROCHLORIDE CALMODULIN ANTAGONIST;N-(4-aminobutyl)-5-chloro-2-*naphthalenesulfonami;W-13, Hydrochloride - CAS 88519-57-7 - Calbiochem;N-(4-AMINOBUTYL)-5-CHLORO-2-NAPHTHALENESULFONAMIDE HCL;4-[(5-chloro-2-naphthalenyl)sulfonylamino]butylammonium;N-(4-Aminohexyl)-5-chloro-2-naphthalenesulfonamide hydrochloride
CBNumber
CB0466031
Molecular Formula
C14H18Cl2N2O2S
Formula Weight
349.28
MOL File
88519-57-7.mol
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N-(4-AMINOBUTYL)-5-CHLORO-2-NAPHTHALENESULFONAMIDE HYDROCHLORIDE Property

Melting point:
241-243°C
storage temp. 
room temp
solubility 
H2O: Stock solutions of 5 mM are recommended. These stocks should be stable for up to 6 months when stored at 4°C.soluble
form 
powder
color 
white
CAS DataBase Reference
88519-57-7(CAS DataBase Reference)
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Safety

Safety Statements 
22-24/25
WGK Germany 
3
HS Code 
2935.90.9500
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML0717
Product name
W-13
Purity
≥98% (HPLC)
Packaging
5mg
Price
$93.9
Updated
2024/03/01
Sigma-Aldrich
Product number
681636-M
Product name
W-13, Hydrochloride
Packaging
1mg-m
Price
$114
Updated
2021/12/16
Sigma-Aldrich
Product number
681636-M
Product name
W-13, Hydrochloride - CAS 88519-57-7 - Calbiochem
Purity
A cell-permeable and reversible calmodulin antagonist that inhibits myosin light chain kinase (IC?? = 58 μM) and Ca2+-calmodulin-dependent phosphodiesterase (IC?? = 68 μM).
Packaging
1mg
Price
$114
Updated
2021/12/16
TCI Chemical
Product number
A2416
Product name
N-(4-Aminobutyl)-5-chloronaphthalene-2-sulfonamide Hydrochloride
Purity
>98.0%(HPLC)(N)
Packaging
25mg
Price
$48
Updated
2023/06/20
TCI Chemical
Product number
A2416
Product name
N-(4-Aminobutyl)-5-chloronaphthalene-2-sulfonamide Hydrochloride
Purity
>98.0%(HPLC)(N)
Packaging
500mg
Price
$379
Updated
2024/03/01
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N-(4-AMINOBUTYL)-5-CHLORO-2-NAPHTHALENESULFONAMIDE HYDROCHLORIDE Chemical Properties,Usage,Production

Description

W-13 is a naphthalenesulfonamide derivative that acts as a potent antagonist of calmodulin (IC50 = 22 μM) and is widely used to investigate Ca2+/calmodulin-regulated enzyme activities.

Chemical Properties

Beige Solid

Uses

W-13 is a naphthalenesulfonamide derivative that acts as a potent antagonist of calmodulin (IC50 = 22 μM) and is widely used to investigate Ca2+/calmodulin-regulated enzyme activities.

Uses

Calmodulin antagonist that binds to calmodulin and inhibits calcium-ion-calmodulin- regulated activities, including phosphodiesterase activation and myosin light chain kinase127, it is widely used to investigate Ca2+/calmodulin-regulated enzyme activities.

Definition

ChEBI: N-(4-aminobutyl)-5-chloronaphthalene-2-sulfonamide hydrochloride is a hydrochloride salt prepared from equimolar amounts of N-(4-aminobutyl)-5-chloronaphthalene-2-sulfonamide and hydrogen chloride. It contains a N-(4-aminobutyl)-5-chloronaphthalene-2-sulfonamide(1+).

Biological Activity

Calmodulin antagonist (inhibits calmodulin activated PDE activity with an IC 50 of 68 μ M). Inhibits growth of tamoxifen-resistant breast cancer cells.

Biochem/physiol Actions

W-13 has also been shown to inhibit the transcytosis of IgA, recycling of transferrin and overall alter the endocytic pathway in Madin-Darby canine kidney cells.

storage

Store at RT

N-(4-AMINOBUTYL)-5-CHLORO-2-NAPHTHALENESULFONAMIDE HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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N-(4-AMINOBUTYL)-5-CHLORO-2-NAPHTHALENESULFONAMIDE HYDROCHLORIDE Suppliers

Americas 1 Canada 1 China 42 Europe 1 Germany 2 India 3 Japan 2 Switzerland 2 United Kingdom 10 United States 17 USA 1 Global 82
SIGMA-RBI
Tel
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Fax
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Country
Switzerland
ProdList
6896
Advantage
91
Alexis Corporation
Tel
--
Fax
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Email
alexis-ch@alexis-corp.ch
Country
Switzerland
ProdList
3599
Advantage
74
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View Lastest Price from N-(4-AMINOBUTYL)-5-CHLORO-2-NAPHTHALENESULFONAMIDE HYDROCHLORIDE manufacturers

Zhuozhou Wenxi import and Export Co., Ltd
Product
N-(4-AMINOBUTYL)-5-CHLORO-2-NAPHTHALENESULFONAMIDE HYDROCHLORIDE 88519-57-7
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-08-11

88519-57-7, N-(4-AMINOBUTYL)-5-CHLORO-2-NAPHTHALENESULFONAMIDE HYDROCHLORIDERelated Search:

BenzenesulfonaMide, 4-chloro-N-[1-(2-phenylethyl)-2-piperidinylidene]- (S)-3-aMino-4-(3-hexylphenylaMino)-4-oxobutylphosphonic acid (TFA salt) N-[[4-(DIMETHYLAMINO)PHENYL]METHYL]-1,2,3,4-TETRAHYDRO-7-METHOXY-N-[4-(1-METHYLETHYL)PHENYL]-1-NAPHTHALENECARBOXAMIDE HYDROCHLORIDE W-5 HYDROCHLORIDE W123 Exclusive [(3R)-3-Amino-4-[(3-hexylphenyl)amino]-4-oxobutyl]-phosphonic acid mono(trifluoroacetate) Naphthalene Carbon tetrachloride Propylene oxide N-TERT-BUTYL-ALPHA-PHENYLNITRONE N-(4-AMINOBUTYL)-5-CHLORO-1-NAPHTHALENESULFONAMIDE, HYDROCHLORIDE NAPHTHALENE-2-SULFONAMIDE 1-Chloronaphthalene 1,4-Diaminobutane dihydrochloride N-(4-AMINOBUTYL)-2-NAPHTHALENESULFONAMIDE HYDROCHLORIDE N-(4-AMINOBUTYL)-5-CHLORO-2-NAPHTHALENESULFONAMIDE HYDROCHLORIDE

  • W-13, Hydrochloride - CAS 88519-57-7 - Calbiochem
  • 4-[(5-chloro-2-naphthalenyl)sulfonylamino]butylammonium
  • N-(4-AMINOBUTYL)-5-CHLORO-2-NAPHTHALENESULFONAMIDE HYDROCHLORIDE
  • N-(4-AMINOBUTYL)-5-CHLORO-2-NAPHTHALENE SULPHONAMIDE, HYDROCHLORIDE
  • OMEGA-13 HYDROCHLORIDE
  • W-13
  • W-13 HYDROCHLORIDE
  • N-(4-Aminohexyl)-5-chloro-2-naphthalenesulfonamide hydrochloride
  • (+)-5-Hydroxy-8-[5-(5-hydroxy-7-methoxy-4-oxo-4H-1-benzopyran-2-yl)-2-methoxyphenyl]-7-methoxy-2-(4-methoxyphenyl)-4H-1-benzopyran-4-one
  • N-(4-Aminobutyl)-5-chloronaphthalene-2-sulphonamide hydrochloride
  • N-(4-aminobutyl)-5-chloro-2-*naphthalenesulfonami
  • N-(4-AMINOBUTYL)-5-CHLORO-2- &
  • W-13 HYDROCHLORIDE CALMODULIN ANTAGONIST
  • N-(4-AMINOBUTYL)-5-CHLORO-2-NAPHTHALENESULFONAMIDE HCL
  • N-(4-AMinobutyl)-5-chloro-2-naphthalenesulfonaMide Monohydrochloride
  • 2-NaphthalenesulfonaMide, N-(4-aMinobutyl)-5-chloro-, Monohydrochloride
  • <i>N</i>-(4-Aminobutyl)-5-chloronaphthalene-2-sulfonamide Hydrochloride
  • N-(4-AMinobutyl)-5-chloronaphthalene-2-sulfonaMide Hydrochloride
  • N-(4-Aminobutyl)-5-chloronaphthalene-2-sulfonamide Hydrochloride &gt
  • 88519-57-7
  • C14H18Cl2N2O2S
  • C14H17ClN2O2SHCl
  • Intracellular Calcium Signaling
  • Cell Biology
  • Calcium Antagonists
  • Cell Signaling and Neuroscience
  • BioChemical
  • All Inhibitors
  • Inhibitors
  • Protein Kinase Inhibitors and Activators
  • Calcium signaling
  • Amines
  • Aromatics
  • Sulfur & Selenium Compounds