ChemicalBook > CAS DataBase List > [(3R)-3-Amino-4-[(3-hexylphenyl)amino]-4-oxobutyl]-phosphonic acid mono(trifluoroacetate)

[(3R)-3-Amino-4-[(3-hexylphenyl)amino]-4-oxobutyl]-phosphonic acid mono(trifluoroacetate)

Product Name
[(3R)-3-Amino-4-[(3-hexylphenyl)amino]-4-oxobutyl]-phosphonic acid mono(trifluoroacetate)
CAS No.
909725-62-8
Chemical Name
[(3R)-3-Amino-4-[(3-hexylphenyl)amino]-4-oxobutyl]-phosphonic acid mono(trifluoroacetate)
Synonyms
W146;W146 TFA;(R)-3-AMino-(3-hexylphenylaMino)-4-oxobutylphosphonic acid (TFA salt);(R)-3-AMINO-(3-HEXYLPHENYLAMINO)-4-OXOBUTYLPHOSPHONIC ACID (TFA SALT);W146;[(3R)-3-Amino-4-[(3-hexylphenyl)amino]-4-oxobutyl]-phosphonic acid mono(trifluoroacetate)
CBNumber
CB02717540
Molecular Formula
C18H28F3N2O6P
Formula Weight
456.3936906
MOL File
909725-62-8.mol
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[(3R)-3-Amino-4-[(3-hexylphenyl)amino]-4-oxobutyl]-phosphonic acid mono(trifluoroacetate) Property

storage temp. 
Store at -20°C
solubility 
Methanol: 0.1 mg/ml
form 
A crystalline solid
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
10009109
Product name
W146 (trifluoroacetate salt)
Purity
≥95%
Packaging
500μg
Price
$78
Updated
2024/03/01
Cayman Chemical
Product number
10009109
Product name
W146 (trifluoroacetate salt)
Purity
≥95%
Packaging
1mg
Price
$146
Updated
2024/03/01
Cayman Chemical
Product number
10009109
Product name
W146 (trifluoroacetate salt)
Purity
≥95%
Packaging
5mg
Price
$614
Updated
2024/03/01
Cayman Chemical
Product number
10009109
Product name
W146 (trifluoroacetate salt)
Purity
≥95%
Packaging
10mg
Price
$1071
Updated
2024/03/01
Tocris
Product number
3602
Product name
W146
Purity
≥98%(HPLC)
Packaging
1
Price
$173
Updated
2021/12/16
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[(3R)-3-Amino-4-[(3-hexylphenyl)amino]-4-oxobutyl]-phosphonic acid mono(trifluoroacetate) Chemical Properties,Usage,Production

Uses

W146 is a selective antagonists of spingosine-1-phosphate receptor subtype 1.

Biological Activity

W146 acts as an orthosteric antagonist. It is linked to blood lymphopenia and lung edema in mice.

in vivo

W146 (5 mg/kg, ip, prior to AMD3100 administration) pre-treatment shows approximately 8-fold increase of KSL-HSPC mobilization, measured by the CFU-G/M colony forming assays, compared to that in mice treated with AMD3100 alone[3]
The W146-mediated augmentation of KSL-HSPC mobilization is specific, because pretreatment of mice with W140 is unable to produce any effect on AMD3100-stimulated KSL-HSPC mobilization. Injections of W146, W140, JTE013, or Cay10444 do not alter the basal WBC count in mice[3].

Animal Model:Mice (4-6-week-old)[3]
.
Dosage:5 mg/kg.
Administration:IP, 1 hour prior to AMD3100 (ADM) administration.
Result:Significantly increased in KSL-HSPC mobilization compared to that in mice pretreated with dextran followed by AMD3100 administration.

[(3R)-3-Amino-4-[(3-hexylphenyl)amino]-4-oxobutyl]-phosphonic acid mono(trifluoroacetate) Preparation Products And Raw materials

Raw materials

Preparation Products

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[(3R)-3-Amino-4-[(3-hexylphenyl)amino]-4-oxobutyl]-phosphonic acid mono(trifluoroacetate) Suppliers

China 34 United States 6 Global 40
EMMX Biotechnology LLC
Tel
888-539-0666
Fax
888-539-0666
Email
info@emmx.com
Country
United States
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8447
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Codow Chemical Co.,Ltd.
Tel
18620099427
Fax
+86-20-62619665
Email
amy@howeipharm.com
Country
China
ProdList
6687
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55
Shanghai EFE Biological Technology Co., Ltd.
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021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9803
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58
Chengdu Huachun Technology Co., Ltd
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400-1166-196 15982826727
Fax
QQ：800101999
Email
cdhxsj@163.com
Country
China
ProdList
14603
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Shanghai Hongye Biotechnology Co. Ltd
Tel
400-9205774
Email
sales@glpbio.cn
Country
China
ProdList
6777
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ChemeGen(Shanghai) Biotechnology Co.,Ltd.
Tel
18818260767
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QQ 3610331285
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sales@chemegen.com
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China
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11218
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58
MedBioPharmaceutical Technology Inc
Tel
021-69568360 18916172912
Email
order@med-bio.cn
Country
China
ProdList
8140
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58
Shanghai Universal Biotech Co.,Ltd
Tel
15921930842 15921930842
Email
yh-wang@univ-bio.com
Country
China
ProdList
25004
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58
TargetMol Chemicals Inc.
Tel
4008200310
Email
marketing@tsbiochem.com
Country
China
ProdList
24961
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58
Shanghai Tachizaki Biomedical Research Center
Tel
18014399201
Email
sales@chemlab-tachizaki.com
Country
China
ProdList
2742
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58

909725-62-8, [(3R)-3-Amino-4-[(3-hexylphenyl)amino]-4-oxobutyl]-phosphonic acid mono(trifluoroacetate)Related Search:

BenzenesulfonaMide, 4-chloro-N-[1-(2-phenylethyl)-2-piperidinylidene]- (S)-3-aMino-4-(3-hexylphenylaMino)-4-oxobutylphosphonic acid (TFA salt) N-[[4-(DIMETHYLAMINO)PHENYL]METHYL]-1,2,3,4-TETRAHYDRO-7-METHOXY-N-[4-(1-METHYLETHYL)PHENYL]-1-NAPHTHALENECARBOXAMIDE HYDROCHLORIDE W-5 HYDROCHLORIDE W123 Exclusive N-(4-AMINOBUTYL)-5-CHLORO-2-NAPHTHALENESULFONAMIDE HYDROCHLORIDE

  • [(3R)-3-Amino-4-[(3-hexylphenyl)amino]-4-oxobutyl]-phosphonic acid mono(trifluoroacetate)
  • (R)-3-AMino-(3-hexylphenylaMino)-4-oxobutylphosphonic acid (TFA salt)
  • W146
  • (R)-3-AMINO-(3-HEXYLPHENYLAMINO)-4-OXOBUTYLPHOSPHONIC ACID (TFA SALT);W146
  • W146 TFA
  • 909725-62-8
  • C16H27N2O4PC2HF3O2
  • C16H27N2O4PCF3COOH