KN-93 Phosphate
- Product Name
- KN-93 Phosphate
- CAS No.
- 1188890-41-6
- Chemical Name
- KN-93 Phosphate
- Synonyms
- CS-1902;KN 93; KN93;KN-93PHOSPHATE;KN-93 phospate;(E)-KN-93 (phosphate);KN-93 phosphate, >=98%;KN 93 Phosphate (E-form);KN-93 Phosphate USP/EP/BP;(E)-N-(2-(((3-(4-Chlorophenyl)allyl)(methyl)amino)methyl)phenyl)-N-(2-hydroxyethyl)-4-methoxybenzenesulfonamide phosphate;N-[2-[[[3-(4-Chlorophenyl)-2-propenyl]methylamino]methyl]phenyl]-N-(2-hydroxyethyl)-4-methoxybenzenesulphonamide phosphate
- CBNumber
- CB02729653
- Molecular Formula
- C26H32ClN2O8PS
- Formula Weight
- 599.032641
- MOL File
- 1188890-41-6.mol
KN-93 Phosphate Property
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- DMF:25.0(Max Conc. mg/mL);41.73(Max Conc. mM)
DMSO:76.67(Max Conc. mg/mL);127.98(Max Conc. mM)
Water:49.33(Max Conc. mg/mL);82.35(Max Conc. mM) - form
- White to off-white solid.
- Water Solubility
- Soluble in water (10mM)
- CAS DataBase Reference
- 1188890-41-6
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H314Causes severe skin burns and eye damage
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P310Immediately call a POISON CENTER or doctor/physician.
P363Wash contaminated clothing before reuse.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 21472
- Product name
- KN-93 (phosphate)
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 21472
- Product name
- KN-93 (phosphate)
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $116
- Updated
- 2024/03/01
- Product number
- 21472
- Product name
- KN-93 (phosphate)
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $184
- Updated
- 2024/03/01
- Product number
- 21472
- Product name
- KN-93 (phosphate)
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $343
- Updated
- 2024/03/01
- Product number
- 5215
- Product name
- KN93phosphate
- Purity
- ≥98%(HPLC)
- Packaging
- 1
- Price
- $141
- Updated
- 2021/12/16
KN-93 Phosphate Chemical Properties,Usage,Production
Description
KN-93 (phosphate) is a potent and selective inhibitor of Ca2+/calmodulin-dependent kinase II (CaMKII) (Ki = 370 nM), inhibiting both the α- and β-subunits of CaMKII. It does not have significant effects on cAMP-dependent protein kinase, Ca2+/phospholipid-dependent protein kinase, myosin light chain kinase, or Ca2+ phosphodiesterase activity. It inhibits histamine-induced aminopyrine uptake in parietal cells (IC50 = 300 nM). KN-93 can block voltage-gated potassium (Kv) channels when applied extracellularly, independent of its CaMKII action. More recently, KN-93 has been used to implicate roles for CaMKII in Ca2+-induced Ca2+ release in cardiac myocytes, constitutive phosphorylation of 5-lipoxygenase in 3T3 cells, and Ca2+-dependent activation of HIF-1α in colon cancer cells.
Uses
KN 93 Phosphate is a potent and selective inhibitor of Ca2+/calmodulin-dependent protein kinase II.
storage
-20°C
KN-93 Phosphate Preparation Products And Raw materials
Raw materials
Preparation Products
KN-93 Phosphate Suppliers
- Tel
- 44-20819178-90 02081917890
- Fax
- (0)2080432064
- info@novachemistry.com
- Country
- United Kingdom
- ProdList
- 4381
- Advantage
- 58