ChemicalBook > CAS DataBase List > Savolitinib

Savolitinib

Product Name: Savolitinib
CAS No.: 1313725-88-0
Chemical Name: Savolitinib
Synonyms: Savolitinib;HMPL-504;Savolitinib (AZD6094);CS-2676;Volitinib;AZD-6094);EOS-60799;HMPL0-504;Volitinib USP/EP/BP;AZD-6094 (VOLITINIB)
CBNumber: CB02731160
Molecular Formula: C17H15N9
Formula Weight: 345.36
MOL File: 1313725-88-0.mol

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Savolitinib Property

Melting point:: 205-207°C
Density: 1.55±0.1 g/cm3(Predicted)
storage temp.: -20°C Freezer
solubility: DMSO (Slightly), Methanol (Slightly)
pka: 5.67±0.50(Predicted)
form: Solid
color: Pale Beige
InChI: InChI=1S/C17H15N9/c1-11(12-3-4-15-18-5-6-25(15)10-12)26-17-16(22-23-26)19-8-14(21-17)13-7-20-24(2)9-13/h3-11H,1-2H3/t11-/m0/s1
InChIKey: XYDNMOZJKOGZLS-NSHDSACASA-N
SMILES: C12N=NN([C@H](C3=CN4C=CN=C4C=C3)C)C1=NC(C1=CN(C)N=C1)=CN=2
CAS DataBase Reference: 1313725-88-0

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Danger

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N-Bromosuccinimide Price

TRC

Product number: S142903
Product name: Savolitinib
Packaging: 100mg
Price: $1215
Updated: 2021/12/16

ChemScene

Product number: CS-4062
Product name: Savolitinib
Purity: 99.56%
Packaging: 100mg
Price: $850
Updated: 2021/12/16

ChemScene

Product number: CS-4062
Product name: Savolitinib
Purity: 99.56%
Packaging: 5mg
Price: $100
Updated: 2021/12/16

Biosynth Carbosynth

Product number: BV160378
Product name: Volitinib
Packaging: 5mg
Price: $100
Updated: 2021/12/16

Biosynth Carbosynth

Product number: BV160378
Product name: Volitinib
Packaging: 50mg
Price: $600
Updated: 2021/12/16

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Savolitinib Chemical Properties,Usage,Production

Description

Savolitinib selectively inhibits the MET receptor, blocking the PI3K/AKT/MAPK-signaling pathway as well as downregulating MYC.

Uses

Savolitinib is a potent and highly selective c-Met inhibitor. Savoltinib demonstrated anti-tumor efficacy in a panel of cMet-dysregulated gastric cancer PDX models. Savolitinib also demonstrated good antitmuor activities.

Clinical Use

It is currently being evaluated in phase I clinical trials in combination with EGFR TKIs in NSCLC patients.

Synthesis

The synthesis of savolitinib started with 6-amino-3-carboxypyridine (20.1), which was treated with chloroacetaldehyde to generate the imidazopyridine 20.2. The carboxylic acid was converted to the Weinreb amide 20.3 and treated with methylmagnesium bromide to give the methyl ketone 20.4. The ketone was converted to the chiral amine 20.5 using a commercially available aminotransferase with the cofactors pyridoxal phosphate and isopropylamine as a nitrogen source. After process workup, the amine was isolated as the dihydrochloride salt (20.5). The free base was obtained by treatment with alkaline conditions, which was subsequently reacted with commercially available 3,5-dibromopyrazin-2-amine (20.6) to give the secondary amine 20.7. Next, nitrosyl ion formation and cyclization gave the 1,2,3-triazole 20.8. Finally, Suzuki coupling with 20.9 completed the construction of savolitinib (20). The boronic acid ester 20.9 was obtained from 4-bromo-1-methyl-1H-pyrazole by lithium-halogen exchange and workup with triisopropylborate quenching.

in vivo

Savolitinib (Compound 28; 1-10.0 mg/kg; oral administration; daily; for 21 days; athymic nude mice) demonstrates dose-dependent tumor growth inhibition in a U87MG subcutaneous xenograft model. In addition, none of the mice in the dosing groups exhibits body weight loss during the experiment^[1].

Animal Model:	U87MG xenograft model in athymic nude mice^[1]
Dosage:	1 mg/kg, 2.5 mg/kg and 10.0 mg/kg
Administration:	Oral administration; daily; for 21 days
Result:	Demonstrated dose-dependent tumor growth inhibition in a U87MG subcutaneous xenograft model.

Savolitinib Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Savolitinib manufacturers

Sinoway Industrial co., ltd.

Product: Volitinib 1313725-88-0
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20tons
Release date: 2025-04-07

Hong Kong Tiansheng New Material Trading Co., Ltd

Product: Savolitinib 1313725-88-0
Price: US $38.99/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100KG
Release date: 2021-12-27

Dideu Industries Group Limited

Product: Volitinib 1313725-88-0
Price: US $1.10/g
Min. Order: 1g
Purity: 99.9%
Supply Ability: 100 Tons Min
Release date: 2021-07-05

1313725-88-0, SavolitinibRelated Search:

Selumetinib Sulfate Ibrutinib SU 6668 3-(5,6-Dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(1H-indol-3-yl)-pyrrolidine-2,5-dione INCB39110 X-376 Filgotinib Masitinib Lestaurtinib CAL-101 PLX3397 (Pexidartinib) CO-1686 Momelotinib Verteporfin PLX4032 1-[[4-[(4-Fluoro-2-methyl-1H-indol-5-yl)oxy]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]oxy]-2-propanol ARRY-334543 Decernotinib

AZD6094,Volitinib, HMPL-504, Savolitinib

1-[(1S)-1-Imidazo[1,2-a]pyridin-6-ylethyl]-6-(1-methyl-1H-pyrazol-4-yl)-1H-1,2,3-triazolo[4,5-b]pyrazine

(S)-1-(1-(imidazo[1,2-a]pyridin-6-yl)ethyl)-6-(1-methyl-1H-pyrazol-4-yl)-1H-[1,2,3]triazolo[4,5-b]pyrazine

Volitinib

Savolitinib

HMPL-504(AZD6094, Volitinib)

EOS-60799

AZD-6094)

HMPL-504

Savolitinib (Volitinib

(S)-1-(1-(imidazo[1,2-a] yridine-6-yl)ethyl)-6-(1-methyl-1H-pyrazol-4-yl)-1H-[1,2,3]triazolo[4,5-b]pyrazine

Savolitinib (AZD6094)

(S)-1-(1-(IMIDAZO[1,2-A]

HMPL-504; HMPL504; HMPL504; AZD-6094; AZD 6094; AZD6094

Volitinib (Savolitinib, AZD-6094)

CS-2676

VOLITINIB; HMPL504; AZD-6094;VOLITINIB; HMPL-504; AZD6094; HMPL 504; AZD 6094

Savolitinib(AZD6094, HMPL-504)

1H-1,2,3-Triazolo[4,5-b]pyrazine, 1-[(1S)-1-imidazo[1,2-a]pyridin-6-ylethyl]-6-(1-methyl-1H-pyrazol-4-yl)-

Volitinib USP/EP/BP

4-{1-[(1S)-1-{imidazo[1,2-a]pyridin-6-yl}ethyl]-1H-[ 1,2,3]triazolo[4,5-b]pyrazin-6-yl}-1-methyl-1H-pyra zole

Pharmaceutical Intermediate Volitinib

AZD-6094 (VOLITINIB)

VOLITINIB (AZD6094, SAVOLITINIB)

HMPL0-504

Savolitinib, 10 mM in DMSO

1313725-88-0

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