ARRY-334543

Product Name: ARRY-334543
CAS No.: 845272-21-1
Chemical Name: ARRY-334543
Synonyms: CS-663;ASLAN001);Varlitinib;AR-00334543;ARRY-334543;Varlitinib (ARRY-543);Varlitinib Ditosylate;ARRY-334543 USP/EP/BP;ARRY-334543;ARRY334543;ARRY 334543 (Varlitinib)
CBNumber: CB12582909
Molecular Formula: C22H19ClN6O2S
Formula Weight: 466.94
MOL File: 845272-21-1.mol

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ARRY-334543 Property

Boiling point:: 637.1±65.0 °C(Predicted)
Density: 1.51±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO : 50 mg/mL (107.08 mM; Need ultrasonic)
form: Powder
pka: 6.54±0.70(Predicted)
color: Off-white to yellow
CAS DataBase Reference: 845272-21-1

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H319Causes serious eye irritation

H335May cause respiratory irritation

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P330Rinse mouth.

P391Collect spillage. Hazardous to the aquatic environment

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 27651
Product name: Varlitinib
Packaging: 1mg
Price: $44
Updated: 2024/03/01

Cayman Chemical

Product number: 27651
Product name: Varlitinib
Packaging: 25mg
Price: $745
Updated: 2024/03/01

Cayman Chemical

Product number: 27651
Product name: Varlitinib
Packaging: 5mg
Price: $183
Updated: 2024/03/01

Cayman Chemical

Product number: 27651
Product name: Varlitinib
Packaging: 10mg
Price: $341
Updated: 2024/03/01

TRC

Product number: V099100
Product name: Varlitinib
Packaging: 10mg
Price: $370
Updated: 2021/12/16

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ARRY-334543 Chemical Properties,Usage,Production

Uses

ARRY334543 is a selective and potent ErbB1 and ErbB2 inhibitor with IC50 of 7 nM and 2 nM, respectively.

Enzyme inhibitor

This ErbB1/2 inhibitor (FW = 466.94 g/mol; CAS 845272-21-1), also named (R)-N4 -(3-chloro-4-(thiazol-2-ylmethoxy)phenyl)-N6 -(4-methyl-4,5- dihydrooxazol-2-yl)quinazoline-4,6-diamine, selectively targets the intrinsic protein kinase activities of ErbB1, or Epidermal Growth Factor Receptor (EGFR), IC50 = 7 nM and ErbB2, or Human Epidermal growth factor Receptor (HER2), IC50 = 2 nM. ARRY-334543 also reverses multidrug resistance by antagonizing the activity of ATP-binding cassette subfamily G member 2.

target

ErbB2

ARRY-334543 Preparation Products And Raw materials

Raw materials

Preparation Products

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ARRY-334543 Suppliers

Canada 1 China 75 India 1 United Kingdom 1 United States 15 Global 93

Shanghai Boyle Chemical Co., Ltd.

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Email: sales@boylechem.com
Country: China
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J & K SCIENTIFIC LTD.

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Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
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Jinan Trio PharmaTech Co., Ltd.

Tel: +86 (531) 88811783
Fax: +86 (531) 55696010 QQ 1762738062
Email: sales@trio-pharmatech.com (International market)
Country: China
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NCE Biomedical Co.,Ltd.

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Haoyuan Chemexpress Co., Ltd.

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Shanghai Aladdin Bio-Chem Technology Co.,LTD

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The future of Shanghai Industrial Co., Ltd.

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AdooQ BioScience, LLC

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AdooQ Bioscience CHINA

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SPIRO PHARMA

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View Lastest Price from ARRY-334543 manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: Varlitinib 845272-21-1
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-10-13

845272-21-1, ARRY-334543Related Search:

AZD-6244 Dovitinib Volitinib Bortezomib Icotinib Tariquidar GSK 2334470 Crizotinib Canertinib Filgotinib Decernotinib Masitinib Lestaurtinib CAL-101 PLX3397 (Pexidartinib) CO-1686 Momelotinib 790299-79-5

ARRY-334543

AR-00334543

Varlitinib

(R)-4-[[3-Chloro-4-[(thiazol-2-yl)methoxy]phenyl]amino]-6-[(4-methyl-4,5-dihydrooxazol-2-yl)amino]quinazoline

(R)-N4-(3-chloro-4-(thiazol-2-ylmethoxy)phenyl)-N6-(4-methyl-4,5-dihydrooxazol-2-yl)quinazoline-4,6-diamine

Varlitinib ARRY 334543

ARRY 334543 (Varlitinib)

ASLAN001)

VARLITINIB (ARRY-334543; ASLAN001)

ARRY-334543;ARRY334543

Varlitinib (ARRY-543)

N4-[3-chloro-4-(2-thiazolylmethoxy)phenyl]-N6-[(4R)-4,5-dihydro-4-methyl-2-oxazolyl]-4,6-Quinazoline diamine

Varlitinib Ditosylate

(R)-N4-(3-Chloro-4-(thiazol-2-ylmethoxy)phenyl)-N6-(4-methyl-4,5-dihydrooxazol-2-yl)quinazolin

ARRY-334543;ARRY 334543;ARRY334543

CS-663

4,6-Quinazolinediamine, N4-[3-chloro-4-(2-thiazolylmethoxy)phenyl]-N6-[(4R)-4,5-dihydro-4-methyl-2-oxazolyl]-

ARRY-334543 USP/EP/BP

845272-21-1

C22H19ClN6O2S

Inhibitors