ChemicalBook > CAS DataBase List > ARRY-334543

ARRY-334543

Product Name
ARRY-334543
CAS No.
845272-21-1
Chemical Name
ARRY-334543
Synonyms
CS-663;ASLAN001);Varlitinib;AR-00334543;ARRY-334543;Varlitinib (ARRY-543);Varlitinib Ditosylate;ARRY-334543 USP/EP/BP;ARRY-334543;ARRY334543;ARRY 334543 (Varlitinib)
CBNumber
CB12582909
Molecular Formula
C22H19ClN6O2S
Formula Weight
466.94
MOL File
845272-21-1.mol
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ARRY-334543 Property

Boiling point:
637.1±65.0 °C(Predicted)
Density 
1.51±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO : 50 mg/mL (107.08 mM; Need ultrasonic)
form 
Powder
pka
6.54±0.70(Predicted)
color 
Off-white to yellow
CAS DataBase Reference
845272-21-1
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H319Causes serious eye irritation

H335May cause respiratory irritation

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P330Rinse mouth.

P391Collect spillage. Hazardous to the aquatic environment

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical
Product number
27651
Product name
Varlitinib
Packaging
1mg
Price
$44
Updated
2024/03/01
Cayman Chemical
Product number
27651
Product name
Varlitinib
Packaging
25mg
Price
$745
Updated
2024/03/01
Cayman Chemical
Product number
27651
Product name
Varlitinib
Packaging
5mg
Price
$183
Updated
2024/03/01
Cayman Chemical
Product number
27651
Product name
Varlitinib
Packaging
10mg
Price
$341
Updated
2024/03/01
TRC
Product number
V099100
Product name
Varlitinib
Packaging
10mg
Price
$370
Updated
2021/12/16
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ARRY-334543 Chemical Properties,Usage,Production

Uses

ARRY334543 is a selective and potent ErbB1 and ErbB2 inhibitor with IC50 of 7 nM and 2 nM, respectively.

Enzyme inhibitor

This ErbB1/2 inhibitor (FW = 466.94 g/mol; CAS 845272-21-1), also named (R)-N4 -(3-chloro-4-(thiazol-2-ylmethoxy)phenyl)-N6 -(4-methyl-4,5- dihydrooxazol-2-yl)quinazoline-4,6-diamine, selectively targets the intrinsic protein kinase activities of ErbB1, or Epidermal Growth Factor Receptor (EGFR), IC50 = 7 nM and ErbB2, or Human Epidermal growth factor Receptor (HER2), IC50 = 2 nM. ARRY-334543 also reverses multidrug resistance by antagonizing the activity of ATP-binding cassette subfamily G member 2.

target

ErbB2

ARRY-334543 Preparation Products And Raw materials

Raw materials

Preparation Products

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ARRY-334543 Suppliers

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View Lastest Price from ARRY-334543 manufacturers

Henan Aochuang Chemical Co.,Ltd.
Product
Varlitinib 845272-21-1
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1Ton
Release date
2022-10-13

845272-21-1, ARRY-334543Related Search:

AZD-6244 Dovitinib Volitinib Bortezomib Icotinib Tariquidar GSK 2334470 Crizotinib Canertinib Filgotinib Decernotinib Masitinib Lestaurtinib CAL-101 PLX3397 (Pexidartinib) CO-1686 Momelotinib 790299-79-5

  • ARRY-334543
  • AR-00334543
  • Varlitinib
  • (R)-4-[[3-Chloro-4-[(thiazol-2-yl)methoxy]phenyl]amino]-6-[(4-methyl-4,5-dihydrooxazol-2-yl)amino]quinazoline
  • (R)-N4-(3-chloro-4-(thiazol-2-ylmethoxy)phenyl)-N6-(4-methyl-4,5-dihydrooxazol-2-yl)quinazoline-4,6-diamine
  • Varlitinib ARRY 334543
  • ARRY 334543 (Varlitinib)
  • ASLAN001)
  • VARLITINIB (ARRY-334543; ASLAN001)
  • ARRY-334543;ARRY334543
  • Varlitinib (ARRY-543)
  • N4-[3-chloro-4-(2-thiazolylmethoxy)phenyl]-N6-[(4R)-4,5-dihydro-4-methyl-2-oxazolyl]-4,6-Quinazoline diamine
  • Varlitinib Ditosylate
  • (R)-N4-(3-Chloro-4-(thiazol-2-ylmethoxy)phenyl)-N6-(4-methyl-4,5-dihydrooxazol-2-yl)quinazolin
  • ARRY-334543;ARRY 334543;ARRY334543
  • CS-663
  • 4,6-Quinazolinediamine, N4-[3-chloro-4-(2-thiazolylmethoxy)phenyl]-N6-[(4R)-4,5-dihydro-4-methyl-2-oxazolyl]-
  • ARRY-334543 USP/EP/BP
  • Varlitinib, 10 mM in DMSO
  • 845272-21-1
  • C22H19ClN6O2S
  • Inhibitors