ChemicalBook > CAS DataBase List > N-Methylbenzamide

N-Methylbenzamide

Product Name: N-Methylbenzamide
CAS No.: 613-93-4
Chemical Name: N-Methylbenzamide
Synonyms: 1MVR;N-Methylbenzenamide;Benzamide, N-methyl-;n-methyl-benzamid;N-METHYLBENZAMIDE;N-Methylbenzamide, 95%;N-METHYLBENZAMIDE, 99+%;N-Methylbenzamide;n-methylbenzenecarboxamide;N-MethylbenzaMide, 99+% 10GR
CBNumber: CB0273752
Molecular Formula: C8H9NO
Formula Weight: 135.16
MOL File: 613-93-4.mol

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N-Methylbenzamide Property

Melting point:: 76-78 °C (lit.)
Boiling point:: 167 °C/11 mmHg (lit.)
Density: 1.1031 (rough estimate)
refractive index: 1.5589 (estimate)
storage temp.: Sealed in dry,Room Temperature
solubility: ethanol: soluble50mg/mL, clear, yellow-green
pka: 15.00±0.46(Predicted)
form: Solid
color: White to off-white
Water Solubility: Insoluble in water.
InChI: InChI=1S/C8H9NO/c1-9-8(10)7-5-3-2-4-6-7/h2-6H,1H3,(H,9,10)
InChIKey: NCCHARWOCKOHIH-UHFFFAOYSA-N
SMILES: C(NC)(=O)C1=CC=CC=C1
CAS DataBase Reference: 613-93-4(CAS DataBase Reference)
EPA Substance Registry System: N-Methylbenzamide (613-93-4)

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Safety

Hazard Codes: Xn
Risk Statements: 20/21/22-22
Safety Statements: 24/25
WGK Germany: 1
RTECS: CV5570000
TSCA: Yes
HS Code: 29242990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 222798
Product name: N-Methylbenzamide
Purity: ≥99%
Packaging: 5g
Price: $68.1
Updated: 2023/01/07

Sigma-Aldrich

Product number: 222798
Product name: N-Methylbenzamide
Purity: ≥99%
Packaging: 10g
Price: $116
Updated: 2023/01/07

TCI Chemical

Product number: M1680
Product name: N-Methylbenzamide
Purity: min. 98.0 %
Packaging: 5G
Price: $53
Updated: 2025/07/31

TCI Chemical

Product number: M1680
Product name: N-Methylbenzamide
Purity: min. 98.0 %
Packaging: 25G
Price: $162
Updated: 2025/07/31

American Custom Chemicals Corporation

Product number: CHM0157106
Product name: N-METHYLBENZAMIDE
Purity: 95.00%
Packaging: 10G
Price: $1158.18
Updated: 2021/12/16

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N-Methylbenzamide Chemical Properties,Usage,Production

Chemical Properties

N-methylbenzamide is an off-white crystalline solid.

Uses

N-Methylbenzamide is an important pesticide intermediate. It acts as a potent PDE10A (phosphodiesterase with a remarkable localization as the protein is abundant only in brain tissue) inhibitor.

Synthesis Reference(s)

Synthetic Communications, 7, p. 549, 1977 DOI: 10.1080/00397917709409275
Tetrahedron Letters, 30, p. 451, 1989 DOI: 10.1016/S0040-4039(00)95225-0

Air & Water Reactions

Insoluble in water.

Reactivity Profile

N-METHYLBENZAMIDE is an amide. Amides/imides react with azo and diazo compounds to generate toxic gases. Flammable gases are formed by the reaction of organic amides/imides with strong reducing agents. Amides are very weak bases (weaker than water). Imides are less basic yet and in fact react with strong bases to form salts. That is, they can react as acids. Mixing amides with dehydrating agents such as P2O5 or SOCl2 generates the corresponding nitrile. The combustion of these compounds generates mixed oxides of nitrogen (NOx).

Fire Hazard

Flash point data concerning N-METHYLBENZAMIDE are not available, however, N-METHYLBENZAMIDE is probably combustible.

Synthesis

Add benzoic acid (977 mg, 8 mmol), dry DCM (20 mL) and catalytic amount of DMF in a 100 mL round-bottom flask. Cool the reaction mixture to 0°C and stir for 5 minutes. Add (COCl)2 (0.89 mL, 1.3 equiv.) dropwise to the reaction mixture and stir at room temperature for 4 hours. Concentrate the resulting mixture under reduced pressure to obtain acid chloride. Add catalytic amount of 4-dimethylaminopyridine, dry DCM (15 mL), MeNH2 (2 (M) in THF) (5.19 mL, 1.3 equiv.) and Et3N (1.56 mL, 1.4 equiv.) to the mixture in a 100 mL round-bottom flask. Cool the reaction mixture to 0°C. Add acid chloride (1.0 equiv.) dropwise at 0°C. Stir the reaction mixture at room temperature for 12 hours. Add water (40 mL) and seperate the organic layer. Extract the aqueous layer with DCM (3 x 30 mL). Wash the combined organic layer with saturated aqueous NaHCO3 (30 mL) solution followed by water (30 mL). Dry the organic layer over Na2SO4 and concentrated under reduced pressure. Purify the crude mass by silica gel column chromatography (20% ethyl acetate in hexane as eluent) to obtain N-methylbenzamide. DOI: 10.1002/anie.202203539

N-Methylbenzamide Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from N-Methylbenzamide manufacturers

Shenzhen Nexcon Pharmatechs Ltd.

Product: N-Methylbenzamide 613-93-4
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 2000
Release date: 2025-07-22

Guangzhou Tengyue Chemical Co., Ltd.

Product: N-Methylbenzamide 613-93-4
Price: US $100.00/kg
Min. Order: 1kg
Purity: 99% Purity (What/sapp: +86 18145728414)
Supply Ability: 1000 Tons/Month
Release date: 2023-12-18

Henan Aochuang Chemical Co.,Ltd.

Product: N-METHYLBENZAMIDE 613-93-4
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1ton
Release date: 2022-09-22

613-93-4, N-MethylbenzamideRelated Search:

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N-METHYLBENZAMIDE

n-methyl-benzamid

N-Methylbenzenamide

n-methylbenzenecarboxamide

N-METHYLBENZAMIDE, 99+%

Benzamide, N-methyl- (6CI,7CI,8CI,9CI)

N-MethylbenzaMide, 99+% 10GR

Benzamide, N-methyl-

1MVR

N-Methylbenzamide, 10 mM in DMSO

<i>N</i>-Methylbenzamide

N-Methylbenzamide, 95%

613-93-4

C6H5CONHCH3

Amides

Building Blocks

Carbonyl Compounds

Organic Building Blocks

Amides

Carbonyl Compounds

Organic Building Blocks

AMIDE

613-93-4