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Salicyluric acid

Product Name
Salicyluric acid
CAS No.
487-54-7
Chemical Name
Salicyluric acid
Synonyms
NSC 524135;salicylurate;SALICYLGYCINE;SALICYLGLYCINE;salicyluricaci;SALICYLURIC ACID;Salicyloylglycine;TIMTEC-BB SBB000337;NSC 524135-13C2,15N;n-salicyloyl-glycin
CBNumber
CB0292276
Molecular Formula
C9H9NO4
Formula Weight
195.17
MOL File
487-54-7.mol
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Salicyluric acid Property

Melting point:
164-169 °C
Boiling point:
331.83°C (rough estimate)
Density 
1.3544 (rough estimate)
refractive index 
1.5700 (estimate)
storage temp. 
Store at 0°C
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
Powder, Crystals or Chunks
pka
3.68±0.10(Predicted)
color 
White to light yellow
Stability:
Hygroscopic
CAS DataBase Reference
487-54-7(CAS DataBase Reference)
EPA Substance Registry System
Glycine, N-(2-hydroxybenzoyl)- (487-54-7)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
24/25-36/37/39-27-26
RTECS 
MR8160000
HS Code 
29242998
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P233Keep container tightly closed.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304IF INHALED:

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P340Remove victim to fresh air and keep at rest in a position comfortable for breathing.

P362Take off contaminated clothing and wash before reuse.

P403Store in a well-ventilated place.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
49861
Product name
o-Hydroxyhippuric acid
Purity
analytical standard
Packaging
50mg
Price
$64.2
Updated
2024/03/01
TRC
Product number
H942885
Product name
2-HydroxyHippuricAcid
Packaging
5g
Price
$190
Updated
2021/12/16
Usbiological
Product number
279114
Product name
2-Hydroxy hippuric acid
Packaging
1g
Price
$375
Updated
2021/12/16
Matrix Scientific
Product number
113611
Product name
2-Hydroxyhippuric acid
Purity
97%
Packaging
5g
Price
$295
Updated
2021/12/16
Matrix Scientific
Product number
113611
Product name
2-Hydroxyhippuric acid
Purity
97%
Packaging
1g
Price
$72
Updated
2021/12/16
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Salicyluric acid Chemical Properties,Usage,Production

Description

Salicyluric acid is an N-acylglycine in which the acyl group is specified as 2-hydroxybenzoyl. It has a role as a uremic toxin and a human xenobiotic metabolite. It is a N-acylglycine and a secondary carboxamide. It is functionally related to a glycine. It is a conjugate acid of a salicylurate.

Chemical Properties

Light gray crystalline powder

Uses

Metabolite of Salicylic Acid (S088125).
2-Hydroxyhippuric acid is a phenol marker. Can be associated with dietary intake or bacterial overgrowth.
Indicators of Detoxification: A conjugate of the amino acid glycine and hydroxybenzoic acid (salicylic acid). Intake of aspirin (salicylates) or the growth of salicylate-producing gastrointestinal bacteria may elevate levels. Also increased after the ingestion of the artificial sweetener aspartame (Nutrasweet).

Definition

ChEBI: An N-acylglycine in which the acyl group is specified as 2-hydroxybenzoyl.

Synthesis

The synthesis of Salicyluric acid is as follows:
To a solution of 5 g of glycine in 50ml of 10%NaOH was stirred at room temperature upon slowaddition of salicyloyl chloride, and the resultingmixture was stirred overnight. Progress of the reaction was followed by TLC (hexane : ethylacetate, 7 : 3).Then the reaction mixture was treated with crushed iceupon stirring. Concentrated HCl was added dropwiseand stirring was continued until the mixture turnedacidic. For removing the residual benzoic acid the mixture was treated with 10-12 mL of CCl4, boiled and then filtered. A pinkish white solid was obtained, yield 90%, mp 165°C.

Salicyluric acid Preparation Products And Raw materials

Raw materials

Preparation Products

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Salicyluric acid Suppliers

J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
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China
ProdList
96815
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76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
4006608290; 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40241
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3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15848
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Capot Chemical Co., Ltd
Tel
+86 (0) 571 85 58 67 18
Fax
0086-571-85864795
Email
sales@capotchem.com
Country
China
ProdList
18217
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Nanjing Chemlin Chemical Co., Ltd
Tel
025-83697070 13913916777;
Fax
+86-25-83453306
Email
info@chemlin.com.cn
Country
China
ProdList
17840
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Chemsky(shanghai)International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32344
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50
Maya High Purity Chemicals
Tel
+86 (573) 82222445 (0)18006601000 452520369
Fax
+86 (573) 82222643
Email
sales@maya-r.com
Country
China
ProdList
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Spectrum Chemical Manufacturing Corp.
Tel
021-021-021-67601398-809-809-809 15221380277
Fax
021-57711696
Email
marketing_china@spectrumchemical.com
Country
China
ProdList
9664
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60
Thermo Fisher Scientific
Tel
800-810-5118
Fax
+86-10-84193589
Email
cnchemical@thermofisher.com
Country
China
ProdList
17779
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75
Beijing innoChem Science & Technology Co.,Ltd.
Tel
400-810-7969 010-59572699
Fax
010-59572688
Email
ningzi.li@inno-chem.com.cn
Country
China
ProdList
6139
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55
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View Lastest Price from Salicyluric acid manufacturers

Zhuozhou Wenxi import and Export Co., Ltd
Product
2-HYDROXYHIPPURIC ACID 487-54-7
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-08-11
Career Henan Chemical Co
Product
2-HYDROXYHIPPURIC ACID 487-54-7
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
1000KG
Release date
2019-12-17

487-54-7, Salicyluric acidRelated Search:


  • TIMTEC-BB SBB000337
  • SALICYLURIC ACID
  • SALICYLGLYCINE
  • SALICYLGYCINE
  • O-HYDROXYHIPPURIC ACID
  • Glycine, N-(2-hydroxybenzoyl)-
  • Hippuric acid, o-hydroxy-
  • Salicylglycine, {[(2-Hydroxyphenyl)carbonyl]amino}acetic acid
  • 2-Hydroxyhippuric acid, 97% 2.5GR
  • NSC 524135
  • (2-Hydroxybenzoyl)glycine-13C2,15N
  • N-(2-Hydroxybenzoyl)glycine-13C2,15N
  • NSC 524135-13C2,15N
  • o-Hydroxyhippuric Acid-13C2,15N
  • Salicyloylglycine-13C2,15N
  • Salicyluric Acid-13C2,15N
  • [(2-Hydroxybenzoyl)amino]acetic acid, 2-Hydroxyhippuric acid
  • 2-Hydroxybenzoylaminoacetic acid, Salicylglycine
  • 2-Hydroxyhippuric acid,97%
  • 2-Hydroxyhippuric acidSalicylglycine
  • 2-(2-hydroxybenzamido)acetic acid
  • n-(2-hydroxybenzoyl)-glycin
  • n-(2-hydroxybenzoyl)glycine
  • N-o-Hydroxybenzoylglycine
  • n-salicyloyl-glycin
  • N-Salicyloylglycine
  • o-hydroxy-hippuricaci
  • ortho-Hydroxyhippuric acid
  • Salicyloylglycine
  • salicylurate
  • IFLAB-BB F1918-0024
  • 2-(2-hydroxybenzoyl)aminoacetic acid
  • HIPPURICACID,ORTHO-HYDROXY-
  • 2-HYDROXYHIPPURIC ACID
  • [(2-HYDROXYBENZOYL)AMINO]ACETIC ACID
  • (2-HYDROXYBENZOYL)GLYCINE
  • salicyluricaci
  • inhibit,Inhibitor,Salicyluric acid,Endogenous Metabolite
  • Paracetamol Impurity 20
  • 487-54-7
  • Metabolites & Impurities
  • Aromatics Compounds
  • Aromatics