Salicyluric acid

ChemicalBook > CAS DataBase List > Salicyluric acid

Product Name: Salicyluric acid
CAS No.: 487-54-7
Chemical Name: Salicyluric acid
Synonyms: NSC 524135;salicylurate;SALICYLGYCINE;SALICYLGLYCINE;salicyluricaci;SALICYLURIC ACID;Salicyloylglycine;TIMTEC-BB SBB000337;NSC 524135-13C2,15N;n-salicyloyl-glycin
CBNumber: CB0292276
Molecular Formula: C9H9NO4
Formula Weight: 195.17
MOL File: 487-54-7.mol

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Salicyluric acid Property

Melting point:: 164-169 °C
Boiling point:: 331.83°C (rough estimate)
Density: 1.3544 (rough estimate)
refractive index: 1.5700 (estimate)
storage temp.: Store at 0°C
solubility: DMSO (Slightly), Methanol (Slightly)
form: Powder, Crystals or Chunks
pka: 3.68±0.10(Predicted)
color: White to light yellow
Stability:: Hygroscopic
CAS DataBase Reference: 487-54-7(CAS DataBase Reference)
EPA Substance Registry System: Glycine, N-(2-hydroxybenzoyl)- (487-54-7)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 24/25-36/37/39-27-26
RTECS: MR8160000
HS Code: 29242998

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P233Keep container tightly closed.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304IF INHALED:

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P340Remove victim to fresh air and keep at rest in a position comfortable for breathing.

P362Take off contaminated clothing and wash before reuse.

P403Store in a well-ventilated place.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 49861
Product name: o-Hydroxyhippuric acid
Purity: analytical standard
Packaging: 50mg
Price: $64.2
Updated: 2024/03/01

TRC

Product number: H942885
Product name: 2-HydroxyHippuricAcid
Packaging: 5g
Price: $190
Updated: 2021/12/16

Usbiological

Product number: 279114
Product name: 2-Hydroxy hippuric acid
Packaging: 1g
Price: $375
Updated: 2021/12/16

Matrix Scientific

Product number: 113611
Product name: 2-Hydroxyhippuric acid
Purity: 97%
Packaging: 5g
Price: $295
Updated: 2021/12/16

Matrix Scientific

Product number: 113611
Product name: 2-Hydroxyhippuric acid
Purity: 97%
Packaging: 1g
Price: $72
Updated: 2021/12/16

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Salicyluric acid Chemical Properties,Usage,Production

Description

Salicyluric acid is an N-acylglycine in which the acyl group is specified as 2-hydroxybenzoyl. It has a role as a uremic toxin and a human xenobiotic metabolite. It is a N-acylglycine and a secondary carboxamide. It is functionally related to a glycine. It is a conjugate acid of a salicylurate.

Chemical Properties

Light gray crystalline powder

Uses

Metabolite of Salicylic Acid (S088125).
2-Hydroxyhippuric acid is a phenol marker. Can be associated with dietary intake or bacterial overgrowth.
Indicators of Detoxification: A conjugate of the amino acid glycine and hydroxybenzoic acid (salicylic acid). Intake of aspirin (salicylates) or the growth of salicylate-producing gastrointestinal bacteria may elevate levels. Also increased after the ingestion of the artificial sweetener aspartame (Nutrasweet).

Definition

ChEBI: An N-acylglycine in which the acyl group is specified as 2-hydroxybenzoyl.

Synthesis

The synthesis of Salicyluric acid is as follows:
To a solution of 5 g of glycine in 50ml of 10%NaOH was stirred at room temperature upon slowaddition of salicyloyl chloride, and the resultingmixture was stirred overnight. Progress of the reaction was followed by TLC (hexane : ethylacetate, 7 : 3).Then the reaction mixture was treated with crushed iceupon stirring. Concentrated HCl was added dropwiseand stirring was continued until the mixture turnedacidic. For removing the residual benzoic acid the mixture was treated with 10-12 mL of CCl4, boiled and then filtered. A pinkish white solid was obtained, yield 90%, mp 165°C.

Salicyluric acid Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Salicyluric acid manufacturers

Zhuozhou Wenxi import and Export Co., Ltd

Product: 2-HYDROXYHIPPURIC ACID 487-54-7
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-08-11

Career Henan Chemical Co

Product: 2-HYDROXYHIPPURIC ACID 487-54-7
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 1000KG
Release date: 2019-12-17

487-54-7, Salicyluric acidRelated Search:

Salicyluric acid ANTIMYCIN A1 OCHRATOXIN B OCHRATOXIN A Hippuric acid Uric acid Pradimicin L Pradimicin B Dexylosylbenanomicin A 1-(2-ethoxybenzoyl)pyrrolidine-2-carboxylic acid Benanomicin A Pradimicin A citreamicin alpha citreamicin eta ANTIMYCIN A2 Benanomicin B 5-BROMO-2-HYDROXYHIPPURIC ACID 97 P-HYDROXYHIPPURIC ACID

TIMTEC-BB SBB000337

SALICYLURIC ACID

SALICYLGLYCINE

SALICYLGYCINE

O-HYDROXYHIPPURIC ACID

Glycine, N-(2-hydroxybenzoyl)-

Hippuric acid, o-hydroxy-

Salicylglycine, {[(2-Hydroxyphenyl)carbonyl]amino}acetic acid

2-Hydroxyhippuric acid, 97% 2.5GR

NSC 524135

(2-Hydroxybenzoyl)glycine-13C2,15N

N-(2-Hydroxybenzoyl)glycine-13C2,15N

NSC 524135-13C2,15N

o-Hydroxyhippuric Acid-13C2,15N

Salicyloylglycine-13C2,15N

Salicyluric Acid-13C2,15N

[(2-Hydroxybenzoyl)amino]acetic acid, 2-Hydroxyhippuric acid

2-Hydroxybenzoylaminoacetic acid, Salicylglycine

2-Hydroxyhippuric acid,97%

2-Hydroxyhippuric acidSalicylglycine

2-(2-hydroxybenzamido)acetic acid

n-(2-hydroxybenzoyl)-glycin

n-(2-hydroxybenzoyl)glycine

N-o-Hydroxybenzoylglycine

n-salicyloyl-glycin

N-Salicyloylglycine

o-hydroxy-hippuricaci

ortho-Hydroxyhippuric acid

Salicyloylglycine

salicylurate

IFLAB-BB F1918-0024

2-(2-hydroxybenzoyl)aminoacetic acid

HIPPURICACID,ORTHO-HYDROXY-

2-HYDROXYHIPPURIC ACID

[(2-HYDROXYBENZOYL)AMINO]ACETIC ACID

(2-HYDROXYBENZOYL)GLYCINE

salicyluricaci

inhibit,Inhibitor,Salicyluric acid,Endogenous Metabolite

Paracetamol Impurity 20

487-54-7

Metabolites & Impurities

Aromatics Compounds

Aromatics