ChemicalBook > CAS DataBase List > Nile Red
Nile Red
- Product Name
- Nile Red
- CAS No.
- 7385-67-3
- Chemical Name
- Nile Red
- Synonyms
- NILE BLUE A OXAZONE;Fluorescent Spectral Standard E, certified;9-(DIETHYLAMINO)-5H-BENZO[A]PHENOXAZIN-5-ONE;nile;NILE RED;nilereddye;Phenoxazone;Oxazine O-17M;Nile Red ,99%;Phenoxazone 9
- CBNumber
- CB0273873
- Molecular Formula
- C20H18N2O2
- Formula Weight
- 318.37
- MOL File
- 7385-67-3.mol
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Nile Red Property
- Melting point:
- 203-205 °C(lit.)
- Boiling point:
- 457.53°C (rough estimate)
- Density
- 1.1871 (rough estimate)
- refractive index
- 1.5700 (estimate)
- storage temp.
- 2-8°C
- solubility
- methanol: soluble1mg/mL
- form
- Powder
- pka
- 4.08±0.20(Predicted)
- color
- Dark red to maroon
- Appearance
- Green to Dark Green Solid
- λmax
- 553 nm
- BRN
- 279110
- Stability:
- Stable. Incompatible with strong oxidizing agents.
- InChI
- InChI=1S/C20H18N2O2/c1-3-22(4-2)13-9-10-16-18(11-13)24-19-12-17(23)14-7-5-6-8-15(14)20(19)21-16/h5-12H,3-4H2,1-2H3
- InChIKey
- VOFUROIFQGPCGE-UHFFFAOYSA-N
- SMILES
- C12=CC=CC=C1C(=O)C=C1C2=NC2=C(C=C(N(CC)CC)C=C2)O1
- CAS DataBase Reference
- 7385-67-3(CAS DataBase Reference)
- EPA Substance Registry System
- 5H-Benzo[a]phenoxazin-5-one, 9-(diethylamino)- (7385-67-3)
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- 72485
- Product name
- Nile Red
- Purity
- for microscopy
- Packaging
- 1g
- Price
- $735
- Updated
- 2025/07/31
Sigma-Aldrich
- Product number
- 19123
- Product name
- Nile Red
- Purity
- BioReagent, suitable for fluorescence, ≥98.0% (HPLC)
- Packaging
- 10mg
- Price
- $118
- Updated
- 2025/07/31
TCI Chemical
- Product number
- N1272
- Product name
- Nile Red [for Biochemical Research]
- Packaging
- 100MG
- Price
- $74
- Updated
- 2025/07/31
TCI Chemical
- Product number
- N0659
- Product name
- Nile Red
- Packaging
- 500mg
- Price
- $164
- Updated
- 2025/07/31
TCI Chemical
- Product number
- N1272
- Product name
- Nile Red [for Biochemical Research]
- Packaging
- 500MG
- Price
- $222
- Updated
- 2025/07/31
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Nile Red Chemical Properties,Usage,Production
Description
Nile Red is an aphotostable and lipophilic stain for intracellular lipids and hydrophobic domains of proteins and also for staining of lysosomal phospholipid inclusions.
Uses
Nile red is a lipophilic stain. It stains intracellular lipid droplets. Nile red is also intensely fluorescent, with a strong yellow-gold emission if included into a lipid-rich environment.
Definition
Nile Red is an organic heterotetracyclic compound that is 5H-benzo[a]phenoxazin-5-one substituted at position 9 by a diethylamino group.
Application
Used as a polarity-sensitive fluorescent probe of lipids and proteins.
General Description
Nile Red is an uncharged hydrophobic molecule and a benzophenoxazone dye. It functions as a fluorescent probe for intracellular lipids and hydrophobic domains of proteins. This dye is fluorescent in all organic solvents. Its fluorescence colors range from golden yellow to deep red.
Synthesis
Using the 1,3-Naphthalenediol Approach to synthsis Nile red. To a solution of 1,3-naphthalenediol (0.50 g, 3.12 mmol) in anhydrous DMF (25 mL) was added 4-nitroso-N,N-diethylaniline (0.56 g, 3.12 mmol). This reaction mixture was stirred at 80 °C (DrySyn heating block) for 16 h and concentrated under reduced pressure. The crude product was purified by flash chromatography (0?50% EtOAc in hexanes) to obtain Nile Red, which crystallized from hexanes in green crystals (0.80 g, 2.50 mmol). Yield: 80%[1].
storage
Room temperature
References
[1] Mick Hornum*. “Substituted 9-Diethylaminobenzo[a]phenoxazin-5-ones (Nile Red Analogues): Synthesis and Photophysical Properties.” The Journal of Organic Chemistry 86 2 (2020): 1471–1488.
Nile Red Preparation Products And Raw materials
Raw materials
Ethanol
2-Hydroxy-1,4-naphoquinone
3-Diethylaminophenol
Nickel
Sodium nitrite
Diethyl ether
1,4-Naphthoquinone
Hydrochloric acid
Acetic acid
Sodium hydroxide
Isopropyl alcohol
Preparation Products
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View Lastest Price from Nile Red manufacturers
WUHAN FORTUNA CHEMICAL CO., LTD
- Product
- Nile Red 7385-67-3
- Price
- US $0.00-0.00/g
- Min. Order
- 1g
- Purity
- 95%
- Supply Ability
- 1kg/month
- Release date
- 2021-05-28
Hebei Chuanghai Biotechnology Co., Ltd
- Product
- NILE RED 7385-67-3
- Price
- US $30.00-10.00/KG
- Min. Order
- 50KG
- Purity
- 99%
- Supply Ability
- 500000kg
- Release date
- 2024-11-04
Zhuozhou Wenxi import and Export Co., Ltd
- Product
- NILE RED 7385-67-3
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10
7385-67-3, Nile Red Related Search:
m-Anisidine
3-Diethylaminophenol
3-Dimethylaminophenol
o-Phenetidine
3-ETHYLAMINOPHENOL
INDOPHENOL BLUE
N,N-Diethyl-1,4-phenylenediamine
Nile Red
3-Dimethylaminoanisole
Rifalazil
4-METHOXY-3-BUTEN-2-ONE
N-Benzylideneaniline
3-METHOXY-N-METHYLANILINE
ETH-(E)-YLIDENE-PHENYL-AMINE
3-ETHOXY-N,N-DIETHYLANILINE
2-PHENYLETHYL PHENYL ETHER
Benzoxazine
9-DIETHYLAMINO-2-HYDROXY-5H-BENZ(A)-