ChemicalBook > CAS DataBase List > DODMA

DODMA

Product Name: DODMA
CAS No.: 104162-47-2
Chemical Name: DODMA
Synonyms: 1,2-Dioleyloxy-3-dimethylamino-propane (DODMA);DODMA;R-DODMA;MBN 305A;98.0% (TLC);2-amino-2,3-dimethyloleanol;2,3-Dioleyloxy-1-(dimethylamino)propane;1,2-Dioleyloxy-3-(dimethylamino)propane;1,2-dioleoxy-3-dimethylamino-propane (DODMA);2,3-Dioleyloxy-1-(dimethylamino)propane >=98.0% (TLC)
CBNumber: CB02755573
Molecular Formula: C41H81NO2
Formula Weight: 620.09
MOL File: 104162-47-2.mol

Less

DODMA Property

Boiling point:: 649.7±55.0 °C(Predicted)
Density: 0.869±0.06 g/cm3(Predicted)
storage temp.: -20°C
solubility: Soluble in Ethanol, DMSO, DMF
pka: 8.65±0.28(Predicted)
form: Liquid
color: Colorless to light yellow
biological source: synthetic
BRN: 10139013
InChIKey: GLGLUQVVDHRLQK-WRBBJXAJSA-N
SMILES: C(N(C)C)C(OCCCCCCCC/C=C\CCCCCCCC)COCCCCCCCC/C=C\CCCCCCCC

Less

Safety

WGK Germany: 3

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H331Toxic if inhaled

H336May cause drowsiness or dizziness

H351Suspected of causing cancer

H372Causes damage to organs through prolonged or repeated exposure

Precautionary statements

P201Obtain special instructions before use.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 53467
Product name: 2,3-Dioleyloxy-1-(dimethylamino)propane
Purity: ≥98.0% (TLC)
Packaging: 100mg
Price: $181
Updated: 2025/07/31

Sigma-Aldrich

Product number: 53467
Product name: 2,3-Dioleyloxy-1-(dimethylamino)propane
Purity: ≥98.0% (TLC)
Packaging: 500mg
Price: $717
Updated: 2025/07/31

Cayman Chemical

Product number: 15109
Product name: 1,2-Dioleyloxy-3-dimethylamino-propane
Purity: ≥98%
Packaging: 50mg
Price: $55
Updated: 2024/03/01

Cayman Chemical

Product number: 15109
Product name: 1,2-Dioleyloxy-3-dimethylamino-propane
Purity: ≥98%
Packaging: 100mg
Price: $99
Updated: 2024/03/01

Cayman Chemical

Product number: 15109
Product name: 1,2-Dioleyloxy-3-dimethylamino-propane
Purity: ≥98%
Packaging: 250mg
Price: $206
Updated: 2024/03/01

Less

DODMA Chemical Properties,Usage,Production

Description

1,2-Dioleyloxy-3-dimethylamino-propane (DODMA) is a cationic lipid containing the unsaturated long-chain (18:1) oleic acid inserted at both the sn-1 and sn-2 positions. It has been used in the composition of liposomes formulated as stable nucleic acid lipid particles that can encapsulate siRNA or other small molecules to be used for drug delivery.

Chemical Properties

DODMA is a colourless to light yellow liquid; soluble in ethanol, DMSO, DMF; stored at -20℃.

Uses

1,2-Dioleyloxy-3-dimethylamino-propane is a cationic lipid containing the unsaturated long-chain (18:1) oleic acid inserted at both the sn-1 and sn-2 positions. It has been used in the composition of lipospomes formulated as stable nucleic acid lipid particles that can encapsulate siRNA or other small molecules to be used for drug delivery.[Cayman Chemical]

Uses

DODMA is responsible for the formation and morphology of lipid nanoparticles containing ionizable cationic lipids and siRNA useful for silencing disease-?causing genes in hepatocytes following i.v. administration.

Application

DODMA is suitable for use in the preparation of lipid nanoparticles (LNPs).

Biochem/physiol Actions

DODMA (1,2-dioleyloxy-3-dimethylaminopropane) is used in the preparation of cationic liposomes and lipid nanoparticles (LNPs). LNPs with DODMA has low or neutral zeta potential. DODMA is efficient in encapsulating nucleic acid during synthesis by reducing the physiological pH. DODMA is implicated in gene therapy.

References

[1] MANUEL J. CARRASCO. Ionization and structural properties of mRNA lipid nanoparticles influence expression in intramuscular and intravascular administration[J]. Communications Biology, 2021: 1-15. DOI: 10.1038/s42003-021-02441-2
[2] DAVID B FENSKE Pieter R C Arcadio Chonn. Liposomal nanomedicines: an emerging field.[J]. Toxicologic Pathology, 2008, 36 1: 21-29. DOI: 10.1177/0192623307310960
[3] JAMES HEYES . Cationic lipid saturation influences intracellular delivery of encapsulated nucleic acids[J]. Journal of Controlled Release, 2005, 107 2: Pages 276-287. DOI: 10.1016/j.jconrel.2005.06.014
[4] SYED BENAZIR ALAM. Apolipoprotein C3 facilitates internalization of cationic lipid nanoparticles into bone marrow-derived mouse mast cells.[J]. Scientific Reports, 2023, 13 1: 431. DOI: 10.1038/s41598-022-25737-7
[5] JAYESHA. KULKARNI. On the Formation and Morphology of Lipid Nanoparticles Containing Ionizable Cationic Lipids and siRNA[J]. ACS Nano, 2018, 12 5: 4787-4795. DOI: 10.1021/acsnano.8b01516

DODMA Preparation Products And Raw materials

Raw materials

Preparation Products

Less

DODMA Suppliers

China 97 United States 5 Global 102

Suzhou Highfine Biotech Co., Ltd

Tel: 0512-69209928 18796809688
Fax: 0512-68417696
Email: zhouyingxiang@highfine.com
Country: China
ProdList: 475
Advantage: 75

Shochem(Shanghai)Co.,Ltd

Tel: +86-021-51783479 +86-13816874662
Fax: 021-50800795
Email: info@shochem.com
Country: China
ProdList: 307
Advantage: 58

Yunnan Huapai Pharmaceutical Technology Co., Ltd.

Tel: 0886-1313565-2018 18662190408
Email: 275443226@qq.com
Country: China
ProdList: 148
Advantage: 58

Beijing Ouhe Technology Co., Ltd

Tel: 010-010-82967028 13522913783
Fax: +86-10-82967029
Email: 2355560935@qq.com
Country: China
ProdList: 12000
Advantage: 60

Shanghai Aladdin Bio-Chem Technology Co.,LTD

Tel: 400-6206333 13167063860
Fax: 021-50323701
Email: anhua.mao@aladdin-e.com
Country: China
ProdList: 25003
Advantage: 65

Bide Pharmatech Ltd.

Tel: 400-164-7117 13681763483
Fax: +86-21-61629029
Email: product02@bidepharm.com
Country: China
ProdList: 39966
Advantage: 60

Yichang Zhongyitai Trading Co., Ltd.

Tel: 0717-6449896 13886658719
Fax: 0717-6558598
Email: root@zhongyitai.com
Country: China
ProdList: 1978
Advantage: 58

Shanghai AECOM Biotechnology Co. , Ltd.

Tel: 021-021-20956531 18116226605
Fax: 021-20956532
Email: sui@neosunpharm.com
Country: China
ProdList: 349
Advantage: 55

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
Advantage: 60

ShangHai Biochempartner Co.,Ltd

Tel: 177-54423994 17754423994
Fax: QQ:2853530913
Email: 2853530910@QQ.com
Country: China
ProdList: 8000
Advantage: 62

Wuhan Wsem Biological Co., Ltd.

Tel: 027-83778876 13667159345
Fax: 027-83778876
Email: 13667159345@163.com
Country: China
ProdList: 1997
Advantage: 55

Shanghai Zhen Li Biological Technology Co., Ltd

Tel: 021-16621358918; 18516310516
Fax: 13045646768
Email: zhenlipharma888@163.com
Country: China
ProdList: 19035
Advantage: 58

Aikon International Limited

Tel: 025-58859352 18068836627
Fax: 02557626880
Email: sales01@aikonchem.com
Country: China
ProdList: 15083
Advantage: 58

Shanghai Haohong Pharmaceutical Co., Ltd.

Tel: 400-8210725 400821072
Fax: 021-58955996
Email: malulu@leyan.com
Country: China
ProdList: 25000
Advantage: 58

Shanghai Hongye Biotechnology Co. Ltd

Tel: 400-9205774
Email: sales@glpbio.cn
Country: China
ProdList: 6777
Advantage: 58

Jinan Carbotang Biotech Co.,Ltd.

Tel: +8615866703830
Email: figo.gao@foxmail.com
Country: China
ProdList: 8497
Advantage: 58

Dayang Chem (Hangzhou) Co.,Ltd.

Tel: +86-0571-88938639 +8617705817739
Fax: +86-571-88938652，+86-571- 88492614
Email: info@dycnchem.com
Country: China
ProdList: 52846
Advantage: 58

Baoji Guokang Healthchem Co., Ltd.

Tel: +86-0917-3909592 +86-13892490616
Fax: 09173909592
Email: gksales1@gk-bio.com
Country: China
ProdList: 9209
Advantage: 58

Xiamen Sinopeg Biotech Co., Ltd.

Tel: 400-9189898 17359873007
Email: sales@sinopeg.com
Country: China
ProdList: 530
Advantage: 58

Shochem(Shanghai) Co.,Ltd

Tel: 86-21-50800795
Email: info@shochem.com
Country: CHINA
ProdList: 288
Advantage: 58

AVT(Shanghai) Pharmaceutical Tech Co., Ltd.

Tel: 021-58876118 15692161719
Email: avt013@avt-cn.com
Country: China
ProdList: 96
Advantage: 58

ChemeGen(Shanghai) Biotechnology Co.,Ltd.

Tel: 18818260767
Fax: QQ 3610331285
Email: sales@chemegen.com
Country: China
ProdList: 11218
Advantage: 58

Jiaxing Hengrui Biotechnology Co. LTD

Tel: 0573-0573-82672231 13757365595
Fax: QQ：715584339
Email: regen_chemical1@163.com
Country: China
ProdList: 4839
Advantage: 58

Wuhan Dingxintong Pharmaceutical Co. , Ltd.

Tel: 15871722230
Fax: 2796190295
Email: 15871722230@163.com
Country: China
ProdList: 4686
Advantage: 58

Zhengzhou Alpha Chemical Co. LTD

Tel: 0371-0371-53732842 13383863444
Fax: QQ：3002612166
Email: 3002612166@qq.com
Country: China
ProdList: 9996
Advantage: 58

Shanghai Peinuo Biotechnology Co., Ltd

Tel: 021-58648778 18217200601
Fax: QQ:99286241
Email: bush@perno.cn
Country: China
ProdList: 292
Advantage: 58

Energy Chemical

Tel: 021-58432009 400-005-6266
Fax: 021-58436166
Email: marketing1@energy-chemical.com
Country: China
ProdList: 44894
Advantage: 58

MedBioPharmaceutical Technology Inc

Tel: 021-69568360 18916172912
Email: order@med-bio.cn
Country: China
ProdList: 8140
Advantage: 58

Shaoguan Mingtu Chemical Co., Ltd

Tel: 13411131983
Fax: 0751-2888656
Email: 2407385074@qq.com
Country: China
ProdList: 2034
Advantage: 58

Chongqing Yusi medical technology cable Co., Ltd.

Tel: 023-62795528 18896157519
Email: 18896157519@139.com
Country: China
ProdList: 4952
Advantage: 58

Wuhan Topule

Tel: +86-02787215551 +86-19945035818
Fax: 027-87215551
Email: 2936752263@qq.com
Country: China
ProdList: 7986
Advantage: 58

Wuhan churuike Pharmaceutical Technology Co., Ltd

Tel: 13237139103
Email: 2358168243@qq.com
Country: China
ProdList: 23
Advantage: 58

Zhengzhou Akem Chemical Co., Ltd

Tel: 13303867194
Email: 3001317055@qq.com
Country: China
ProdList: 9681
Advantage: 58

Beijing Jin Ming Biotechnology Co., Ltd.

Tel: 010-60605840 15801484223;
Email: psaitong@jm-bio.com
Country: China
ProdList: 29757
Advantage: 58

Guangzhou Yunmen Biotechnology Co., Ltd

Tel: 0751-18902340975/189023400307 18902340307
Fax: 0751-2819901
Email: 3356812514@qq.com
Country: China
ProdList: 9249
Advantage: 58

Tianjin Yankai Scientific Co. Ltd.

Tel: 18500985499
Email: yankaisale@qq.com
Country: China
ProdList: 481
Advantage: 58

Shaanxi DIDU pharmaceutical and Chemical Co., Ltd

Tel: 029-029-81120477 17792793610
Email: 1033@dideu.com
Country: China
ProdList: 9936
Advantage: 58

JiangSu Star Science Co.,Ltd

Tel: 400-605-7200 15335295587
Email: 3941881028@qq.com
Country: China
ProdList: 3760
Advantage: 58

Jilin Chinese Academy of Sciences - Yanshen Technology Co., Ltd

Tel: 0431-80514535 19917294565
Email: et@chemextension.com
Country: China
ProdList: 5061
Advantage: 58

Hubei Weideli Chemical Reagent Co.，Ltd.

Tel: 027-59222918; 13385289472
Email: Z13385289472@163.com
Country: China
ProdList: 4767
Advantage: 58

TargetMol Chemicals Inc.

Tel: 4008200310
Email: marketing@tsbiochem.com
Country: China
ProdList: 24961
Advantage: 58

Shanghai Maclean Biochemical Technology Co., LTD

Tel: 021-021-50706066 15221275939
Email: shenlinxing@macklin.cn
Country: China
ProdList: 29784
Advantage: 58

Hubei Wanye Zhongcheng Chemical Reagent Co., Ltd.

Tel: 18671296875
Email: 1205035102@qq.com
Country: China
ProdList: 4302
Advantage: 58

SuZhou Yumed Pharmaceutical Technology Co.,Ltd

Tel: 199-5111-2435 19951112435
Email: qibuxiang@163.com
Country: China
ProdList: 62
Advantage: 58

Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 18621169109
Email: market03@meryer.com
Country: China
ProdList: 27987
Advantage: 58

Henan Dowon Chemical Technology Co., Ltd.

Tel: 16696119288
Email: 779113375@qq.com
Country: China
ProdList: 7236
Advantage: 58

Shanghai Easy CDMO Co.,Ltd

Tel: 021-61734564 13854185395;
Email: info@easycdmo.com
Country: China
ProdList: 10024
Advantage: 58

Beijing Solarbio Science & Tecnology Co., Ltd.

Tel: 010-50973130 17801761073
Email: Gsiyu@solarbio.com
Country: China
ProdList: 50464
Advantage: 58

Shanghai Tengjun Biotechnology Co. LTD

Tel: 19821570922
Email: angela@labgogo.com
Country: China
ProdList: 9896
Advantage: 58

Chengdu Dihe Yongxin Pharmaceutical Technology Co., Ltd

Tel: 15928140810 13928288528
Email: lixueyin@desano.com
Country: China
ProdList: 196
Advantage: 58

Less

View Lastest Price from DODMA manufacturers

Hebei Zhuanglai Chemical Trading Co Ltd

Product: DODMA 104162-47-2
Price: US $50.00/kg
Min. Order: 1kg
Purity: 99
Supply Ability: 5000
Release date: 2024-11-14

XIAMEN SINOPEG BIOTECH CO., LTD.

Product: DODMA 104162-47-2
Price: US $0.00-0.00/g
Min. Order: 1g
Purity: 98%
Supply Ability: 1g/bottle , 10g/bottle, 100g/bottle
Release date: 2024-07-26

Zhuozhou Wenxi import and Export Co., Ltd

Product: DODMA 104162-47-2
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

104162-47-2, DODMARelated Search:

Cholesterol DOTAP Soy bean phospholipid Oleic acid SOY LECITHIN Lecithin Hydrogenated PG?(egg?PC) Cholesteryl sodium sulfate Egg phospholipids N-[1-(2,3-DIOLEYLOXY)PROPYL]-N,N,N-TRIMETHYLAMMONIUM CHLORIDE Sodium hyaluronate 1,2-DILAUROYL-SN-GLYCERO-3-PHOSPHOCHOLINE 1,2-DiMyristoyl-sn-glycero-3-phospho-rac-(1-glycerol) SodiuM Salt 1,2-DI13-CIS-DOCOSENOYL-SN-GLYCERO-3-PHOSPHOCHOLINE 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE

1,2-Dioleyloxy-3-(dimethylamino)propane

2,3-Dioleyloxy-1-(dimethylamino)propane

DODMA

N,N-Dimethyl-2,3-bis[(9Z)-9-octadecen-1-yloxy]-1-propanamine

2-amino-2,3-dimethyloleanol

1,2-Dioleyloxy-3-dimethylamino-propane (DODMA)

1-Propanamine, N,N-dimethyl-2,3-bis[(9Z)-9-octadecen-1-yloxy]-

2,3-Dioleyloxy-1-(dimethylamino)propane >=98.0% (TLC)

1-Propanamine, N,N-dimethyl-2,3-bis[(9Z)-9-octadecenyloxy]-, (2S)-

N,N-Dimethyl-2,3-bis((Z)-octadec-9-en-1-yloxy)propan-1-amine

R-DODMA

N,N-Dimethyl-2,3-bis[(9Z)-9-octadecenyloxy]-1-propanamine (2S)-

98.0% (TLC)

1,2-dioleoxy-3-dimethylamino-propane (DODMA)

MBN 305A

2,3-Dioleyloxy-1-(dimethylamino)propane/104162-47-2/98%

104162-47-2