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DODMA

Product Name
DODMA
CAS No.
104162-47-2
Chemical Name
DODMA
Synonyms
1,2-Dioleyloxy-3-dimethylamino-propane (DODMA);DODMA;R-DODMA;98.0% (TLC);2-amino-2,3-dimethyloleanol;2,3-Dioleyloxy-1-(dimethylamino)propane;1,2-Dioleyloxy-3-(dimethylamino)propane;1,2-dioleoxy-3-dimethylamino-propane (DODMA);2,3-Dioleyloxy-1-(dimethylamino)propane >=98.0% (TLC);N,N-Dimethyl-2,3-bis[(9Z)-9-octadecen-1-yloxy]-1-propanamine
CBNumber
CB02755573
Molecular Formula
C41H81NO2
Formula Weight
620.09
MOL File
104162-47-2.mol
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DODMA Property

Boiling point:
649.7±55.0 °C(Predicted)
Density 
0.869±0.06 g/cm3(Predicted)
storage temp. 
-20°C
solubility 
Soluble in Ethanol, DMSO, DMF
pka
8.65±0.28(Predicted)
form 
Liquid
color 
Colorless to light yellow
BRN 
10139013
InChIKey
GLGLUQVVDHRLQK-WRBBJXAJSA-N
SMILES
C(N(C)C)C(OCCCCCCCC/C=C\CCCCCCCC)COCCCCCCCC/C=C\CCCCCCCC
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H331Toxic if inhaled

H336May cause drowsiness or dizziness

H351Suspected of causing cancer

H372Causes damage to organs through prolonged or repeated exposure

Precautionary statements

P201Obtain special instructions before use.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
53467
Product name
2,3-Dioleyloxy-1-(dimethylamino)propane
Purity
≥98.0% (TLC)
Packaging
100mg
Price
$176
Updated
2024/03/01
Sigma-Aldrich
Product number
53467
Product name
2,3-Dioleyloxy-1-(dimethylamino)propane
Purity
≥98.0% (TLC)
Packaging
500mg
Price
$697
Updated
2024/03/01
Cayman Chemical
Product number
15109
Product name
1,2-Dioleyloxy-3-dimethylamino-propane
Purity
≥98%
Packaging
50mg
Price
$55
Updated
2024/03/01
Cayman Chemical
Product number
15109
Product name
1,2-Dioleyloxy-3-dimethylamino-propane
Purity
≥98%
Packaging
100mg
Price
$99
Updated
2024/03/01
Cayman Chemical
Product number
15109
Product name
1,2-Dioleyloxy-3-dimethylamino-propane
Purity
≥98%
Packaging
250mg
Price
$206
Updated
2024/03/01
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DODMA Chemical Properties,Usage,Production

Description

1,2-Dioleyloxy-3-dimethylamino-propane (DODMA) is a cationic lipid containing the unsaturated long-chain (18:1) oleic acid inserted at both the sn-1 and sn-2 positions. It has been used in the composition of liposomes formulated as stable nucleic acid lipid particles that can encapsulate siRNA or other small molecules to be used for drug delivery.

Chemical Properties

DODMA is a colourless to light yellow liquid; soluble in ethanol, DMSO, DMF; stored at -20℃.

Uses

1,2-Dioleyloxy-3-dimethylamino-propane is a cationic lipid containing the unsaturated long-chain (18:1) oleic acid inserted at both the sn-1 and sn-2 positions. It has been used in the composition of lipospomes formulated as stable nucleic acid lipid particles that can encapsulate siRNA or other small molecules to be used for drug delivery.[Cayman Chemical]

Uses

DODMA is responsible for the formation and morphology of lipid nanoparticles containing ionizable cationic lipids and siRNA useful for silencing disease-?causing genes in hepatocytes following i.v. administration.

Application

DODMA is suitable for use in the preparation of lipid nanoparticles (LNPs).

Biochem/physiol Actions

DODMA (1,2-dioleyloxy-3-dimethylaminopropane) is used in the preparation of cationic liposomes and lipid nanoparticles (LNPs).  LNPs with DODMA has low or neutral zeta potential. DODMA is efficient in encapsulating nucleic acid during synthesis by reducing the physiological pH. DODMA is implicated in gene therapy.

DODMA Preparation Products And Raw materials

Raw materials

Preparation Products

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DODMA Suppliers

China 75 United States 5 Global 80
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View Lastest Price from DODMA manufacturers

Hebei Zhuanglai Chemical Trading Co Ltd
Product
DODMA 104162-47-2
Price
US $50.00/kg
Min. Order
1kg
Purity
99
Supply Ability
5000
Release date
2024-11-14
XIAMEN SINOPEG BIOTECH CO., LTD.
Product
DODMA 104162-47-2
Price
US $0.00-0.00/g
Min. Order
1g
Purity
98%
Supply Ability
1g/bottle , 10g/bottle, 100g/bottle
Release date
2024-07-26
Zhuozhou Wenxi import and Export Co., Ltd
Product
DODMA 104162-47-2
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10

104162-47-2, DODMARelated Search:

DOTAP Soy bean phospholipid Oleic acid SOY LECITHIN Lecithin Hydrogenated Cholesterol PG?(egg?PC) Cholesteryl sodium sulfate Egg phospholipids N-[1-(2,3-DIOLEYLOXY)PROPYL]-N,N,N-TRIMETHYLAMMONIUM CHLORIDE Sodium hyaluronate 1,2-DILAUROYL-SN-GLYCERO-3-PHOSPHOCHOLINE 1,2-DiMyristoyl-sn-glycero-3-phospho-rac-(1-glycerol) SodiuM Salt 1,2-DI13-CIS-DOCOSENOYL-SN-GLYCERO-3-PHOSPHOCHOLINE 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE

  • 1,2-Dioleyloxy-3-(dimethylamino)propane
  • 2,3-Dioleyloxy-1-(dimethylamino)propane
  • DODMA
  • N,N-Dimethyl-2,3-bis[(9Z)-9-octadecen-1-yloxy]-1-propanamine
  • 2-amino-2,3-dimethyloleanol
  • 1,2-Dioleyloxy-3-dimethylamino-propane (DODMA)
  • 1-Propanamine, N,N-dimethyl-2,3-bis[(9Z)-9-octadecen-1-yloxy]-
  • 2,3-Dioleyloxy-1-(dimethylamino)propane >=98.0% (TLC)
  • 1-Propanamine, N,N-dimethyl-2,3-bis[(9Z)-9-octadecenyloxy]-, (2S)-
  • N,N-Dimethyl-2,3-bis((Z)-octadec-9-en-1-yloxy)propan-1-amine
  • R-DODMA
  • N,N-Dimethyl-2,3-bis[(9Z)-9-octadecenyloxy]-1-propanamine (2S)-
  • 98.0% (TLC)
  • 1,2-dioleoxy-3-dimethylamino-propane (DODMA)
  • 104162-47-2