DOTAP

Product Name: DOTAP
CAS No.: 144189-73-1
Chemical Name: DOTAP
Synonyms: DOTAP;DOTAP MS;DOTAP METHOSULFATE;DOTAP methyl sulfate;TRANSFECTION REAGENT;18:1 TAP (DOTAP, MS Salt);DOTAP Transfection Reagent;DOTAP(methyl sulfate salt);TRANSFAST(TM) TRANSFECTION REAGENT;TFX(TM) REAGENTS TRANSFECTION TRIO
CBNumber: CB3122792
Molecular Formula: C42H80NO4.CH3O4S
Formula Weight: 774.19
MOL File: 144189-73-1.mol

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DOTAP Property

Density: 1.11 g/cm3
storage temp.: 2-8°C
solubility: Acetonitrile: Slightly soluble
Water: Slightly soluble
form: buffered aqueous suspension
color: clear to hazy colorless to faint yellow
InChIKey: RSMRWWHFJMENJH-LQDDAWAPSA-M
SMILES: C(C[N+](C)(C)C)(COC(=O)CCCCCCC/C=C\CCCCCCCC)OC(=O)CCCCCCC/C=C\CCCCCCCC.S([O-])(=O)(=O)OC

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H331Toxic if inhaled

H336May cause drowsiness or dizziness

H351Suspected of causing cancer

H372Causes damage to organs through prolonged or repeated exposure

Precautionary statements

P202Do not handle until all safety precautions have been read and understood.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P308+P313IF exposed or concerned: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 11202375001
Product name: DOTAP Liposomal Transfection Reagent
Purity: N-[1-(2,3-Dioleoyloxy)propyl]-N,N,N-trimethylammonium methyl-sulfate
Packaging: 5x400μL
Price: $610
Updated: 2025/07/31

Usbiological

Product number: T8198-02
Product name: Transfection Reagent
Packaging: 120ul
Price: $1042
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD157467
Product name: N-[1-(2,3-Dioleoyloxy)propyl]-n,n,n-trimethylammonium methyl-sulfate
Packaging: 250mg
Price: $325
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD157467
Product name: N-[1-(2,3-Dioleoyloxy)propyl]-n,n,n-trimethylammonium methyl-sulfate
Packaging: 500mg
Price: $500
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CBL0000340
Product name: DOTAP METHOSULFATE
Purity: 95.00%
Packaging: 1G
Price: $605.15
Updated: 2021/12/16

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DOTAP Chemical Properties,Usage,Production

Description

18:1 TAP (DOTAP, MS Salt) is a cationic derivative of trimethylammonium linked with two 18-carbon fatty acid tails with single alkene groups in each tail. 18:1 TAP is a cationic liposome-forming compound that may be used for transfection of DNA, RNA, and other negatively charged molecules into eukaryotic cells.

Uses

The DOTAP (N-[1-(2,3-Dioleoyloxy)propyl]-N,N,N-trimethylammonium methyl-sulfate) Liposomal Transfection Reagent is a liposome formulation of the cationic lipid DOTAP. DOTAP can be used for the highly efficient transfection of DNA including yeast artificial chromosomes (YACs) into eukaryotic cells for transient or stable gene expression, and is also suitable for the efficient transfer of other negatively charged molecules, such as RNA, oligonucleotides, nucleotides, ribonucleo-protein (RNP) complexes, and proteins into research samples of mammalian cells.

General Description

DOTAP Liposomal Transfection Reagent is a liposome formulation of the cationic lipid DOTAP. Unlike other liposomal reagents, it produces highly efficient transfections both in the presence and absence of serum. It can also be successfully used for in vivo applications. Mixing DOTAP with DNA results in spontaneously formed stable complexes. These complexes can be added directly to the cell culture medium. This method of DNA transfer is very gentle, avoiding the cytotoxic effects commonly encountered with lipofection or other transfection methods.

Biochem/physiol Actions

DOTAP (1,2-dioleoyl-3-trimethylammonium-propane) is a cationic lipid, used for in vitro and in vivo nucleic acid and protein delivery. The lipid composition and cell type affects the transfection potential of DOTAP. DOTAP mediates gene knockdown technique in hematopoietic stem cells (HSCs).

References

[1] F XIONG N G Z Mi. Cationic liposomes as gene delivery system: transfection efficiency and new application.[J]. Pharmazie, 2011, 66 3: 158-164.

DOTAP Preparation Products And Raw materials

Raw materials

Preparation Products

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DOTAP Suppliers

China 80 Switzerland 1 United Kingdom 3 United States 6 Global 90

Guangzhou Weihua Biotechnology Co., Ltd

Tel: 020-020-37239396 18922492046
Email: weihuasw@foxmail.com
Country: China
ProdList: 4735
Advantage: 58

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Suzhou Highfine Biotech Co., Ltd

Tel: 0512-69209928 18796809688
Fax: 0512-68417696
Email: zhouyingxiang@highfine.com
Country: China
ProdList: 475
Advantage: 75

Shanghai Xingui Biotechnology Co., Ltd.

Tel: 15121041756
Email: xingui2022@126.com
Country: China
ProdList: 9976
Advantage: 58

Shanghai Macklin Biochemical Co.,Ltd.

Tel: 15221275939
Fax: 021-50706099
Email: shenlinxing@macklin.cn
Country: China
ProdList: 15873
Advantage: 55

Shanghai AECOM Biotechnology Co. , Ltd.

Tel: 021-021-20956531 18116226605
Fax: 021-20956532
Email: sui@neosunpharm.com
Country: China
ProdList: 349
Advantage: 55

Sigma-Aldrich

Tel: 021-61415566 800-8193336
Email: orderCN@merckgroup.com
Country: China
ProdList: 51395
Advantage: 80

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
Advantage: 60

Beijing Jin Ming Biotechnology Co., Ltd.

Tel: 010-60605840 18892239720
Fax: 010-60605840
Email: psaitong@jm-bio.com
Country: China
ProdList: 12306
Advantage: 58

Zhengzhou Huiju Chemical Co., Ltd.

Tel: 0371-55900031 18137872243
Fax: QQ：2853979815
Email: 2853979815@qq.com
Country: China
ProdList: 9996
Advantage: 55

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View Lastest Price from DOTAP manufacturers

XIAMEN SINOPEG BIOTECH CO., LTD.

Product: 1,2-dioleoyl-3-trimethylammonium propane (methyl sulfate salt) 144189-73-1
Price: US $0.00-0.00/g
Min. Order: 1g
Purity: 98%
Supply Ability: 1
Release date: 2021-07-07

Zhuozhou Wenxi import and Export Co., Ltd

Product: DOTAP 144189-73-1
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

Zhuozhou Wenxi import and Export Co., Ltd

Product: DOTAP 144189-73-1
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-08

144189-73-1, DOTAPRelated Search:

DOTMA DLinDMA DODMA DOTAP CHLORIDE SALT,dotap chloride,DOTAP DOTAP DOTAP MESYLATE, 98 DOTAP(OH)2 MESYLATE DOTAP DOTAP(OH) MESYLATE DOTAP acetate DOTAP DOTAP CHLORIDE SALT,DOTAP DOTAP METHYL SULPHATE SALT DOTAP MESYLATE

TFX(TM) REAGENTS TRANSFECTION TRIO

N-(2,3-DIOLEOYLOXY-1-PROPYL)TRIMETHYLAMMONIUM METHYL SULFATE

N-[1-(2,3-DIOLEOYLOXY)PROPYL]-N,N,N-TRIMETHYLAMMONIUM METHYL-SULFATE

TRANSFAST(TM) TRANSFECTION REAGENT

TRANSFECTION REAGENT

DOTAP METHOSULFATE

DOTAP

N-(2,3-dioleoyloxy-1-propyl)trime.-amm. me. sulfate

N-(2,3-DIOLEOYLOXY-1-PROPYL)TRIME.-AMM. ME. SULFATE,5X0.4ML

DOTAP methyl sulfate

DOTAP Liposomal Transfection Reagent

DOTAP Transfection Reagent

18:1 TAP (DOTAP, MS Salt)

DOTAP Liposomal Transfection Reagent N-[1-(2,3-Dioleoyloxy)propyl]-N,N,N-trimethylammonium methyl-sulfate

N,N,N-Trimethyl-2,3-bis(oleoyloxy)propan-1-aminium methyl sulfate

DOTAP MS

DOTAP (2,3-dioleyl-propyl) - trimethylamine (MS salt) 5KG

DOTAP(methyl sulfate salt)

[2,3-BIS(OCTADEC-9-ENOYLOXY)PROPYL]TRIMETHYLAZANIUM METHYL SULFATE(1-)

144189-73-1

BioChemical

Transfection & Transformation

Molecular Biology

Cloning and Expression

DMG