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DOTAP

Product Name
DOTAP
CAS No.
144189-73-1
Chemical Name
DOTAP
Synonyms
DOTAP;DOTAP MS;DOTAP METHOSULFATE;DOTAP methyl sulfate;TRANSFECTION REAGENT;18:1 TAP (DOTAP, MS Salt);DOTAP Transfection Reagent;TRANSFAST(TM) TRANSFECTION REAGENT;TFX(TM) REAGENTS TRANSFECTION TRIO;DOTAP Liposomal Transfection Reagent
CBNumber
CB3122792
Molecular Formula
C42H80NO4.CH3O4S
Formula Weight
774.19
MOL File
144189-73-1.mol
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DOTAP Property

Density 
1.11 g/cm3
storage temp. 
2-8°C
form 
buffered aqueous suspension
color 
clear to hazy colorless to faint yellow
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H331Toxic if inhaled

H336May cause drowsiness or dizziness

H351Suspected of causing cancer

H372Causes damage to organs through prolonged or repeated exposure

Precautionary statements

P202Do not handle until all safety precautions have been read and understood.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P308+P313IF exposed or concerned: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
11202375001
Product name
DOTAP Liposomal Transfection Reagent
Purity
N-[1-(2,3-Dioleoyloxy)propyl]-N,N,N-trimethylammonium methyl-sulfate
Packaging
5x400μL
Price
$598
Updated
2024/03/01
Usbiological
Product number
T8198-02
Product name
Transfection Reagent
Packaging
120ul
Price
$1042
Updated
2021/12/16
Biosynth Carbosynth
Product number
FD157467
Product name
N-[1-(2,3-Dioleoyloxy)propyl]-n,n,n-trimethylammonium methyl-sulfate
Packaging
250mg
Price
$325
Updated
2021/12/16
Biosynth Carbosynth
Product number
FD157467
Product name
N-[1-(2,3-Dioleoyloxy)propyl]-n,n,n-trimethylammonium methyl-sulfate
Packaging
500mg
Price
$500
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CBL0000340
Product name
DOTAP METHOSULFATE
Purity
95.00%
Packaging
1G
Price
$605.15
Updated
2021/12/16
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DOTAP Chemical Properties,Usage,Production

Description

18:1 TAP (DOTAP, MS Salt) is a cationic derivative of trimethylammonium linked with two 18-carbon fatty acid tails with single alkene groups in each tail. 18:1 TAP is a cationic liposome-forming compound that may be used for transfection of DNA, RNA, and other negatively charged molecules into eukaryotic cells.

Uses

The DOTAP (N-[1-(2,3-Dioleoyloxy)propyl]-N,N,N-trimethylammonium methyl-sulfate) Liposomal Transfection Reagent is a liposome formulation of the cationic lipid DOTAP. DOTAP can be used for the highly efficient transfection of DNA including yeast artificial chromosomes (YACs) into eukaryotic cells for transient or stable gene expression, and is also suitable for the efficient transfer of other negatively charged molecules, such as RNA, oligonucleotides, nucleotides, ribonucleo-protein (RNP) complexes, and proteins into research samples of mammalian cells.

General Description

DOTAP Liposomal Transfection Reagent is a liposome formulation of the cationic lipid DOTAP. Unlike other liposomal reagents, it produces highly efficient transfections both in the presence and absence of serum. It can also be successfully used for in vivo applications. Mixing DOTAP with DNA results in spontaneously formed stable complexes. These complexes can be added directly to the cell culture medium. This method of DNA transfer is very gentle, avoiding the cytotoxic effects commonly encountered with lipofection or other transfection methods.

Biochem/physiol Actions

DOTAP (1,2-dioleoyl-3-trimethylammonium-propane) is a cationic lipid, used for in vitro and in vivo nucleic acid and protein delivery. The lipid composition and cell type affects the transfection potential of DOTAP. DOTAP mediates gene knockdown technique in hematopoietic stem cells (HSCs).

DOTAP Preparation Products And Raw materials

Raw materials

Preparation Products

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DOTAP Suppliers

Guangzhou Weihua Biotechnology Co., Ltd
Tel
020-020-37239396 18922492046
Email
weihuasw@foxmail.com
Country
China
ProdList
2199
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Suzhou Highfine Biotech Co., Ltd
Tel
0512-68311833 18306219922
Fax
0512-68417696
Email
merry@highfine.com
Country
China
ProdList
499
Advantage
75
Nanjing Chemlin Chemical Co., Ltd
Tel
025-83697070
Fax
+86-25-83453306
Email
info@chemlin.com.cn
Country
China
ProdList
19172
Advantage
64
Shanghai Xingui Biotechnology Co., Ltd.
Tel
17501653715
Email
xingui2022@126.com
Country
China
ProdList
10007
Advantage
58
Shanghai Macklin Biochemical Co.,Ltd.
Tel
15221275939 15221275939
Fax
021-50706099
Email
shenlinxing@macklin.cn
Country
China
ProdList
16166
Advantage
55
Shanghai AECOM Biotechnology Co. , Ltd.
Tel
021-021-20956531 18116226605
Fax
021-20956532
Email
sui@neosunpharm.com
Country
China
ProdList
350
Advantage
55
Sigma-Aldrich
Tel
021-61415566 800-8193336
Email
orderCN@merckgroup.com
Country
China
ProdList
51456
Advantage
80
Beijing Jin Ming Biotechnology Co., Ltd.
Tel
010-60605840 18892239720
Fax
010-60605840
Email
psaitong@jm-bio.com
Country
China
ProdList
12306
Advantage
58
Zhengzhou Huiju Chemical Co., Ltd.
Tel
0371-55900031 18137872243
Fax
QQ:2853979815
Email
2853979815@qq.com
Country
China
ProdList
10010
Advantage
55
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View Lastest Price from DOTAP manufacturers

XIAMEN SINOPEG BIOTECH CO., LTD.
Product
1,2-dioleoyl-3-trimethylammonium propane (methyl sulfate salt) 144189-73-1
Price
US $0.00-0.00/g
Min. Order
1g
Purity
98%
Supply Ability
1
Release date
2021-07-07
Zhuozhou Wenxi import and Export Co., Ltd
Product
DOTAP 144189-73-1
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10
Zhuozhou Wenxi import and Export Co., Ltd
Product
DOTAP 144189-73-1
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-08

144189-73-1, DOTAPRelated Search:


  • TFX(TM) REAGENTS TRANSFECTION TRIO
  • N-(2,3-DIOLEOYLOXY-1-PROPYL)TRIMETHYLAMMONIUM METHYL SULFATE
  • N-[1-(2,3-DIOLEOYLOXY)PROPYL]-N,N,N-TRIMETHYLAMMONIUM METHYL-SULFATE
  • TRANSFAST(TM) TRANSFECTION REAGENT
  • TRANSFECTION REAGENT
  • DOTAP METHOSULFATE
  • DOTAP
  • N-(2,3-dioleoyloxy-1-propyl)trime.-amm. me. sulfate
  • N-(2,3-DIOLEOYLOXY-1-PROPYL)TRIME.-AMM. ME. SULFATE,5X0.4ML
  • DOTAP methyl sulfate
  • DOTAP Liposomal Transfection Reagent
  • DOTAP Transfection Reagent
  • 18:1 TAP (DOTAP, MS Salt)
  • DOTAP Liposomal Transfection Reagent N-[1-(2,3-Dioleoyloxy)propyl]-N,N,N-trimethylammonium methyl-sulfate
  • N,N,N-Trimethyl-2,3-bis(oleoyloxy)propan-1-aminium methyl sulfate
  • DOTAP MS
  • 144189-73-1
  • BioChemical
  • Transfection & Transformation
  • Molecular Biology
  • Cloning and Expression
  • DMG