DODMA

Product Name: DODMA
CAS No.: 104162-47-2
Chemical Name: DODMA
Synonyms: 1,2-Dioleyloxy-3-dimethylamino-propane (DODMA);DODMA;R-DODMA;MBN 305A;98.0% (TLC);2-amino-2,3-dimethyloleanol;2,3-Dioleyloxy-1-(dimethylamino)propane;1,2-Dioleyloxy-3-(dimethylamino)propane;1,2-dioleoxy-3-dimethylamino-propane (DODMA);2,3-Dioleyloxy-1-(dimethylamino)propane >=98.0% (TLC)
CBNumber: CB02755573
Molecular Formula: C41H81NO2
Formula Weight: 620.09
MOL File: 104162-47-2.mol

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DODMA Property

Boiling point:: 649.7±55.0 °C(Predicted)
Density: 0.869±0.06 g/cm3(Predicted)
storage temp.: -20°C
solubility: Soluble in Ethanol, DMSO, DMF
pka: 8.65±0.28(Predicted)
form: Liquid
color: Colorless to light yellow
biological source: synthetic
BRN: 10139013
InChIKey: GLGLUQVVDHRLQK-WRBBJXAJSA-N
SMILES: C(N(C)C)C(OCCCCCCCC/C=C\CCCCCCCC)COCCCCCCCC/C=C\CCCCCCCC

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H331Toxic if inhaled

H336May cause drowsiness or dizziness

H351Suspected of causing cancer

H372Causes damage to organs through prolonged or repeated exposure

Precautionary statements

P201Obtain special instructions before use.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 53467
Product name: 2,3-Dioleyloxy-1-(dimethylamino)propane
Purity: ≥98.0% (TLC)
Packaging: 100mg
Price: $181
Updated: 2025/07/31

Sigma-Aldrich

Product number: 53467
Product name: 2,3-Dioleyloxy-1-(dimethylamino)propane
Purity: ≥98.0% (TLC)
Packaging: 500mg
Price: $717
Updated: 2025/07/31

Cayman Chemical

Product number: 15109
Product name: 1,2-Dioleyloxy-3-dimethylamino-propane
Purity: ≥98%
Packaging: 50mg
Price: $55
Updated: 2024/03/01

Cayman Chemical

Product number: 15109
Product name: 1,2-Dioleyloxy-3-dimethylamino-propane
Purity: ≥98%
Packaging: 100mg
Price: $99
Updated: 2024/03/01

Cayman Chemical

Product number: 15109
Product name: 1,2-Dioleyloxy-3-dimethylamino-propane
Purity: ≥98%
Packaging: 250mg
Price: $206
Updated: 2024/03/01

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DODMA Chemical Properties,Usage,Production

Description

1,2-Dioleyloxy-3-dimethylamino-propane (DODMA) is a cationic lipid containing the unsaturated long-chain (18:1) oleic acid inserted at both the sn-1 and sn-2 positions. It has been used in the composition of liposomes formulated as stable nucleic acid lipid particles that can encapsulate siRNA or other small molecules to be used for drug delivery.

Chemical Properties

DODMA is a colourless to light yellow liquid; soluble in ethanol, DMSO, DMF; stored at -20℃.

Uses

1,2-Dioleyloxy-3-dimethylamino-propane is a cationic lipid containing the unsaturated long-chain (18:1) oleic acid inserted at both the sn-1 and sn-2 positions. It has been used in the composition of lipospomes formulated as stable nucleic acid lipid particles that can encapsulate siRNA or other small molecules to be used for drug delivery.[Cayman Chemical]

Uses

DODMA is responsible for the formation and morphology of lipid nanoparticles containing ionizable cationic lipids and siRNA useful for silencing disease-?causing genes in hepatocytes following i.v. administration.

Application

DODMA is suitable for use in the preparation of lipid nanoparticles (LNPs).

Biochem/physiol Actions

DODMA (1,2-dioleyloxy-3-dimethylaminopropane) is used in the preparation of cationic liposomes and lipid nanoparticles (LNPs). LNPs with DODMA has low or neutral zeta potential. DODMA is efficient in encapsulating nucleic acid during synthesis by reducing the physiological pH. DODMA is implicated in gene therapy.

References

[1] MANUEL J. CARRASCO. Ionization and structural properties of mRNA lipid nanoparticles influence expression in intramuscular and intravascular administration[J]. Communications Biology, 2021: 1-15. DOI: 10.1038/s42003-021-02441-2
[2] DAVID B FENSKE Pieter R C Arcadio Chonn. Liposomal nanomedicines: an emerging field.[J]. Toxicologic Pathology, 2008, 36 1: 21-29. DOI: 10.1177/0192623307310960
[3] JAMES HEYES . Cationic lipid saturation influences intracellular delivery of encapsulated nucleic acids[J]. Journal of Controlled Release, 2005, 107 2: Pages 276-287. DOI: 10.1016/j.jconrel.2005.06.014
[4] SYED BENAZIR ALAM. Apolipoprotein C3 facilitates internalization of cationic lipid nanoparticles into bone marrow-derived mouse mast cells.[J]. Scientific Reports, 2023, 13 1: 431. DOI: 10.1038/s41598-022-25737-7
[5] JAYESHA. KULKARNI. On the Formation and Morphology of Lipid Nanoparticles Containing Ionizable Cationic Lipids and siRNA[J]. ACS Nano, 2018, 12 5: 4787-4795. DOI: 10.1021/acsnano.8b01516

DODMA Preparation Products And Raw materials

Raw materials

Preparation Products

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DODMA Suppliers

China 97 United States 5 Global 102

Suzhou Highfine Biotech Co., Ltd

Tel: 0512-69209928 18796809688
Fax: 0512-68417696
Email: zhouyingxiang@highfine.com
Country: China
ProdList: 475
Advantage: 75

Shochem(Shanghai)Co.,Ltd

Tel: +86-021-51783479 +86-13816874662
Fax: 021-50800795
Email: info@shochem.com
Country: China
ProdList: 307
Advantage: 58

Yunnan Huapai Pharmaceutical Technology Co., Ltd.

Tel: 0886-1313565-2018 18662190408
Email: 275443226@qq.com
Country: China
ProdList: 148
Advantage: 58

Beijing Ouhe Technology Co., Ltd

Tel: 010-010-82967028 13522913783
Fax: +86-10-82967029
Email: 2355560935@qq.com
Country: China
ProdList: 12000
Advantage: 60

Shanghai Aladdin Bio-Chem Technology Co.,LTD

Tel: 400-6206333 13167063860
Fax: 021-50323701
Email: anhua.mao@aladdin-e.com
Country: China
ProdList: 25003
Advantage: 65

Bide Pharmatech Ltd.

Tel: 400-164-7117 13681763483
Fax: +86-21-61629029
Email: product02@bidepharm.com
Country: China
ProdList: 39966
Advantage: 60

Yichang Zhongyitai Trading Co., Ltd.

Tel: 0717-6449896 13886658719
Fax: 0717-6558598
Email: root@zhongyitai.com
Country: China
ProdList: 1978
Advantage: 58

Shanghai AECOM Biotechnology Co. , Ltd.

Tel: 021-021-20956531 18116226605
Fax: 021-20956532
Email: sui@neosunpharm.com
Country: China
ProdList: 349
Advantage: 55

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
Advantage: 60

ShangHai Biochempartner Co.,Ltd

Tel: 177-54423994 17754423994
Fax: QQ:2853530913
Email: 2853530910@QQ.com
Country: China
ProdList: 8000
Advantage: 62

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View Lastest Price from DODMA manufacturers

Hebei Zhuanglai Chemical Trading Co Ltd

Product: DODMA 104162-47-2
Price: US $50.00/kg
Min. Order: 1kg
Purity: 99
Supply Ability: 5000
Release date: 2024-11-14

XIAMEN SINOPEG BIOTECH CO., LTD.

Product: DODMA 104162-47-2
Price: US $0.00-0.00/g
Min. Order: 1g
Purity: 98%
Supply Ability: 1g/bottle , 10g/bottle, 100g/bottle
Release date: 2024-07-26

Zhuozhou Wenxi import and Export Co., Ltd

Product: DODMA 104162-47-2
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

104162-47-2, DODMARelated Search:

Cholesterol DOTAP Soy bean phospholipid Oleic acid SOY LECITHIN Lecithin Hydrogenated PG?(egg?PC) Cholesteryl sodium sulfate Egg phospholipids N-[1-(2,3-DIOLEYLOXY)PROPYL]-N,N,N-TRIMETHYLAMMONIUM CHLORIDE Sodium hyaluronate 1,2-DILAUROYL-SN-GLYCERO-3-PHOSPHOCHOLINE 1,2-DiMyristoyl-sn-glycero-3-phospho-rac-(1-glycerol) SodiuM Salt 1,2-DI13-CIS-DOCOSENOYL-SN-GLYCERO-3-PHOSPHOCHOLINE 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE

1,2-Dioleyloxy-3-(dimethylamino)propane

2,3-Dioleyloxy-1-(dimethylamino)propane

DODMA

N,N-Dimethyl-2,3-bis[(9Z)-9-octadecen-1-yloxy]-1-propanamine

2-amino-2,3-dimethyloleanol

1,2-Dioleyloxy-3-dimethylamino-propane (DODMA)

1-Propanamine, N,N-dimethyl-2,3-bis[(9Z)-9-octadecen-1-yloxy]-

2,3-Dioleyloxy-1-(dimethylamino)propane >=98.0% (TLC)

1-Propanamine, N,N-dimethyl-2,3-bis[(9Z)-9-octadecenyloxy]-, (2S)-

N,N-Dimethyl-2,3-bis((Z)-octadec-9-en-1-yloxy)propan-1-amine

R-DODMA

N,N-Dimethyl-2,3-bis[(9Z)-9-octadecenyloxy]-1-propanamine (2S)-

98.0% (TLC)

1,2-dioleoxy-3-dimethylamino-propane (DODMA)

MBN 305A

2,3-Dioleyloxy-1-(dimethylamino)propane/104162-47-2/98%

104162-47-2