DODMA
- Product Name
- DODMA
- CAS No.
- 104162-47-2
- Chemical Name
- DODMA
- Synonyms
- 1,2-Dioleyloxy-3-dimethylamino-propane (DODMA);DODMA;R-DODMA;98.0% (TLC);2-amino-2,3-dimethyloleanol;2,3-Dioleyloxy-1-(dimethylamino)propane;1,2-Dioleyloxy-3-(dimethylamino)propane;2,3-Dioleyloxy-1-(dimethylamino)propane >=98.0% (TLC);N,N-Dimethyl-2,3-bis[(9Z)-9-octadecen-1-yloxy]-1-propanamine;N,N-Dimethyl-2,3-bis((Z)-octadec-9-en-1-yloxy)propan-1-amine
- CBNumber
- CB02755573
- Molecular Formula
- C41H81NO2
- Formula Weight
- 620.09
- MOL File
- 104162-47-2.mol
DODMA Property
- Boiling point:
- 649.7±55.0 °C(Predicted)
- Density
- 0.869±0.06 g/cm3(Predicted)
- storage temp.
- -20°C
- solubility
- Soluble in Ethanol, DMSO, DMF
- pka
- 8.65±0.28(Predicted)
- BRN
- 10139013
- InChIKey
- GLGLUQVVDHRLQK-WRBBJXAJSA-N
- SMILES
- C(N(C)C)C(OCCCCCCCC/C=C\CCCCCCCC)COCCCCCCCC/C=C\CCCCCCCC
Safety
- WGK Germany
- 3
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H331Toxic if inhaled
H336May cause drowsiness or dizziness
H351Suspected of causing cancer
H372Causes damage to organs through prolonged or repeated exposure
- Precautionary statements
-
P201Obtain special instructions before use.
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
N-Bromosuccinimide Price
- Product number
- 53467
- Product name
- 2,3-Dioleyloxy-1-(dimethylamino)propane
- Purity
- ≥98.0% (TLC)
- Packaging
- 100mg
- Price
- $176
- Updated
- 2024/03/01
- Product number
- 53467
- Product name
- 2,3-Dioleyloxy-1-(dimethylamino)propane
- Purity
- ≥98.0% (TLC)
- Packaging
- 500mg
- Price
- $697
- Updated
- 2024/03/01
- Product number
- 15109
- Product name
- 1,2-Dioleyloxy-3-dimethylamino-propane
- Purity
- ≥98%
- Packaging
- 50mg
- Price
- $55
- Updated
- 2024/03/01
- Product number
- 15109
- Product name
- 1,2-Dioleyloxy-3-dimethylamino-propane
- Purity
- ≥98%
- Packaging
- 100mg
- Price
- $99
- Updated
- 2024/03/01
- Product number
- 15109
- Product name
- 1,2-Dioleyloxy-3-dimethylamino-propane
- Purity
- ≥98%
- Packaging
- 250mg
- Price
- $206
- Updated
- 2024/03/01
DODMA Chemical Properties,Usage,Production
Description
1,2-Dioleyloxy-3-dimethylamino-propane (DODMA) is a cationic lipid containing the unsaturated long-chain (18:1) oleic acid inserted at both the sn-1 and sn-2 positions. It has been used in the composition of liposomes formulated as stable nucleic acid lipid particles that can encapsulate siRNA or other small molecules to be used for drug delivery.
Chemical Properties
DODMA is a colourless to light yellow liquid; soluble in ethanol, DMSO, DMF; stored at -20℃.
Uses
1,2-Dioleyloxy-3-dimethylamino-propane is a cationic lipid containing the unsaturated long-chain (18:1) oleic acid inserted at both the sn-1 and sn-2 positions. It has been used in the composition of lipospomes formulated as stable nucleic acid lipid particles that can encapsulate siRNA or other small molecules to be used for drug delivery.[Cayman Chemical]
Uses
DODMA is responsible for the formation and morphology of lipid nanoparticles containing ionizable cationic lipids and siRNA useful for silencing disease-?causing genes in hepatocytes following i.v. administration.
Application
DODMA is suitable for use in the preparation of lipid nanoparticles (LNPs).
Biochem/physiol Actions
DODMA (1,2-dioleyloxy-3-dimethylaminopropane) is used in the preparation of cationic liposomes and lipid nanoparticles (LNPs). LNPs with DODMA has low or neutral zeta potential. DODMA is efficient in encapsulating nucleic acid during synthesis by reducing the physiological pH. DODMA is implicated in gene therapy.
DODMA Preparation Products And Raw materials
Raw materials
Preparation Products
DODMA Suppliers
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View Lastest Price from DODMA manufacturers
- Product
- DODMA 104162-47-2
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10
- Product
- DODMA 104162-47-2
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-08