DOTMA

Product Name: DOTMA
CAS No.: 104872-42-6
Chemical Name: DOTMA
Synonyms: R-DOTMA-Cl;1,2-di-O-octadecenyl-3-trimethylammonium propane (chloride salt);N,N,N-Trimethyl-2,3-bis(octadec-9-en-1-yloxy)propan-1-aminium chloride;1,2-di-O-octadecenyl-3-trimethylammonium propane (chloride salt)(DOTMA);(1 cis trans) -1,2-dioleoxy-3- (trimethylammonium) propane gas salt (cis trans DOTMA-CL)
CBNumber: CB86188272
Molecular Formula: C42H84ClNO2
Formula Weight: 670.59
MOL File: 104872-42-6.mol

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DOTMA Property

storage temp.: -20°C
solubility: DMSO:50.0(Max Conc. mg/mL);0.03(Max Conc. mM)
form: Solid
color: White to light yellow
InChIKey: LDGWQMRUWMSZIU-UHFFFAOYSA-M
SMILES: C(C[N+](C)(C)C)(OCCCCCCCCC=CCCCCCCCC)COCCCCCCCCC=CCCCCCCCC.[Cl-]

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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DOTMA Chemical Properties,Usage,Production

Description

DOTMA is one of the first cationic lipid used for gene transfection. DOTMA carries a positive charge on the surface of liposomes which condenses anionic nucleic acids and promotes efficient interactions between the cell membrane and the liposome.

Uses

DOTMA is used for drug delivery and gene transfection. When used as a component of liposomes, it is used to encapsulate siRNAs, miRNAs and oligonucleotides, etc., to form carrier liposomes (LPX), which are used in anticancer vaccine research.DOTMA has shown good gene transfection effects both in vitro and in vivo. It can also be used as a development of new visualisers.

Biochem/physiol Actions

DOTMA is a cationic lipid, used as a non-viral vector for gene therapy. It exhibits effective in vitro and in vivo gene transfection. DOTMA induces a positive charge on the liposomes and thus promotes efficient liposome - cell membrane interaction.

in vivo

DOTMA shows high intravenous transfection activity in CD-1 mouse^[3].

DOTMA Preparation Products And Raw materials

Raw materials

Preparation Products

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DOTMA Suppliers

China 67 United States 5 Global 72

Shochem(Shanghai)Co.,Ltd

Tel: +86-021-51783479 +86-13816874662
Fax: 021-50800795
Email: info@shochem.com
Country: China
ProdList: 307
Advantage: 58

Shochem (Shanghai) Co.,Ltd

Tel: 13611745246 13816874662
Email: sales@shochem.com
Country: China
ProdList: 534
Advantage: 58

Beijing HwrkChemical Technology Co., Ltd

Tel: 18515581800 18501085097
Fax: 010-89508210
Email: sales.bj@hwrkchemical.com
Country: China
ProdList: 9400
Advantage: 55

Shanghai Aladdin Bio-Chem Technology Co.,LTD

Tel: 400-6206333 13167063860
Fax: 021-50323701
Email: anhua.mao@aladdin-e.com
Country: China
ProdList: 25003
Advantage: 65

Shanghai Macklin Biochemical Co.,Ltd.

Tel: 15221275939
Fax: 021-50706099
Email: shenlinxing@macklin.cn
Country: China
ProdList: 15873
Advantage: 55

Shanghai AECOM Biotechnology Co. , Ltd.

Tel: 021-021-20956531 18116226605
Fax: 021-20956532
Email: sui@neosunpharm.com
Country: China
ProdList: 349
Advantage: 55

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
Advantage: 60

Shanghai Zhen Li Biological Technology Co., Ltd

Tel: 021-16621358918; 18516310516
Fax: 13045646768
Email: zhenlipharma888@163.com
Country: China
ProdList: 19035
Advantage: 58

Aikon International Limited

Tel: 025-58859352 18068836627
Fax: 02557626880
Email: sales01@aikonchem.com
Country: China
ProdList: 15083
Advantage: 58

Jinan Carbotang Biotech Co.,Ltd.

Tel: +8615866703830
Email: figo.gao@foxmail.com
Country: China
ProdList: 8497
Advantage: 58

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View Lastest Price from DOTMA manufacturers

Chongqing Soarwin Technology Co., Ltd

Product: DOTMA 104872-42-6
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 99.99%
Supply Ability: 20 tons
Release date: 2025-04-10

XIAMEN SINOPEG BIOTECH CO., LTD.

Product: DOTMA 104872-42-6
Price: US $0.00-0.00/g
Min. Order: 1g
Purity: 98%
Supply Ability: 1g/bottle , 10g/bottle, 100g/bottle
Release date: 2024-07-26

104872-42-6, DOTMARelated Search:

DLinDMA N-[1-(2,3-DIOLEYLOXY)PROPYL]-N,N,N-TRIMETHYLAMMONIUM CHLORIDE DOTAP DODMA

1,2-di-O-octadecenyl-3-trimethylammonium propane (chloride salt)

N,N,N-Trimethyl-2,3-bis(octadec-9-en-1-yloxy)propan-1-aminium chloride

R-DOTMA-Cl

1,2-di-O-octadecenyl-3-trimethylammonium propane (chloride salt)(DOTMA)

(1 cis trans) -1,2-dioleoxy-3- (trimethylammonium) propane gas salt (cis trans DOTMA-CL)

104872-42-6