DOTMA
- Product Name
- DOTMA
- CAS No.
- 104872-42-6
- Chemical Name
- DOTMA
- Synonyms
- R-DOTMA-Cl;1,2-di-O-octadecenyl-3-trimethylammonium propane (chloride salt);N,N,N-Trimethyl-2,3-bis(octadec-9-en-1-yloxy)propan-1-aminium chloride;1,2-di-O-octadecenyl-3-trimethylammonium propane (chloride salt)(DOTMA)
- CBNumber
- CB86188272
- Molecular Formula
- C42H84ClNO2
- Formula Weight
- 670.59
- MOL File
- 104872-42-6.mol
DOTMA Property
- solubility
- DMSO:50.0(Max Conc. mg/mL);0.03(Max Conc. mM)
- InChIKey
- LDGWQMRUWMSZIU-UHFFFAOYSA-M
- SMILES
- C(C[N+](C)(C)C)(OCCCCCCCCC=CCCCCCCCC)COCCCCCCCCC=CCCCCCCCC.[Cl-]
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
DOTMA Chemical Properties,Usage,Production
Description
DOTMA is one of the first cationic lipid used for gene transfection. DOTMA carries a positive charge on the surface of liposomes which condenses anionic nucleic acids and promotes efficient interactions between the cell membrane and the liposome.
Uses
DOTMA is used for drug delivery and gene transfection. When used as a component of liposomes, it is used to encapsulate siRNAs, miRNAs and oligonucleotides, etc., to form carrier liposomes (LPX), which are used in anticancer vaccine research.DOTMA has shown good gene transfection effects both in vitro and in vivo. It can also be used as a development of new visualisers.
Biochem/physiol Actions
DOTMA is a cationic lipid, used as a non-viral vector for gene therapy. It exhibits effective in vitro and in vivo gene transfection. DOTMA induces a positive charge on the liposomes and thus promotes efficient liposome - cell membrane interaction.
DOTMA Preparation Products And Raw materials
Raw materials
Preparation Products
DOTMA Suppliers
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