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DOTMA

Product Name
DOTMA
CAS No.
104872-42-6
Chemical Name
DOTMA
Synonyms
R-DOTMA-Cl;1,2-di-O-octadecenyl-3-trimethylammonium propane (chloride salt);N,N,N-Trimethyl-2,3-bis(octadec-9-en-1-yloxy)propan-1-aminium chloride;1,2-di-O-octadecenyl-3-trimethylammonium propane (chloride salt)(DOTMA);(1 cis trans) -1,2-dioleoxy-3- (trimethylammonium) propane gas salt (cis trans DOTMA-CL)
CBNumber
CB86188272
Molecular Formula
C42H84ClNO2
Formula Weight
670.59
MOL File
104872-42-6.mol
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DOTMA Property

storage temp. 
-20°C
solubility 
DMSO:50.0(Max Conc. mg/mL);0.03(Max Conc. mM)
form 
Solid
color 
White to light yellow
InChIKey
LDGWQMRUWMSZIU-UHFFFAOYSA-M
SMILES
C(C[N+](C)(C)C)(OCCCCCCCCC=CCCCCCCCC)COCCCCCCCCC=CCCCCCCCC.[Cl-]
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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DOTMA Chemical Properties,Usage,Production

Description

DOTMA is one of the first cationic lipid used for gene transfection. DOTMA carries a positive charge on the surface of liposomes which condenses anionic nucleic acids and promotes efficient interactions between the cell membrane and the liposome.

Uses

DOTMA is used for drug delivery and gene transfection. When used as a component of liposomes, it is used to encapsulate siRNAs, miRNAs and oligonucleotides, etc., to form carrier liposomes (LPX), which are used in anticancer vaccine research.DOTMA has shown good gene transfection effects both in vitro and in vivo. It can also be used as a development of new visualisers.

Biochem/physiol Actions

DOTMA is a cationic lipid, used as a non-viral vector for gene therapy. It exhibits effective in vitro and in vivo gene transfection. DOTMA induces a positive charge on the liposomes and thus promotes efficient liposome - cell membrane interaction.

in vivo

DOTMA shows high intravenous transfection activity in CD-1 mouse[3].

DOTMA Preparation Products And Raw materials

Raw materials

Preparation Products

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DOTMA Suppliers

China 67 United States 5 Global 72
Shochem(Shanghai)Co.,Ltd
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+86-021-51783479 +86-13816874662
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info@shochem.com
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Shochem (Shanghai) Co.,Ltd
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13611745246 13816874662
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sales@shochem.com
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Beijing HwrkChemical Technology Co., Ltd
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Shanghai Aladdin Bio-Chem Technology Co.,LTD
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400-6206333 13167063860
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Shanghai Macklin Biochemical Co.,Ltd.
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Energy Chemical
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InvivoChem
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TargetMol Chemicals Inc.
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Asymchem Labs.
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View Lastest Price from DOTMA manufacturers

Chongqing Soarwin Technology Co., Ltd
Product
DOTMA 104872-42-6
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
99.99%
Supply Ability
20 tons
Release date
2025-04-10
XIAMEN SINOPEG BIOTECH CO., LTD.
Product
DOTMA 104872-42-6
Price
US $0.00-0.00/g
Min. Order
1g
Purity
98%
Supply Ability
1g/bottle , 10g/bottle, 100g/bottle
Release date
2024-07-26

104872-42-6, DOTMARelated Search:

DLinDMA N-[1-(2,3-DIOLEYLOXY)PROPYL]-N,N,N-TRIMETHYLAMMONIUM CHLORIDE DOTAP DODMA

  • 1,2-di-O-octadecenyl-3-trimethylammonium propane (chloride salt)
  • N,N,N-Trimethyl-2,3-bis(octadec-9-en-1-yloxy)propan-1-aminium chloride
  • R-DOTMA-Cl
  • 1,2-di-O-octadecenyl-3-trimethylammonium propane (chloride salt)(DOTMA)
  • (1 cis trans) -1,2-dioleoxy-3- (trimethylammonium) propane gas salt (cis trans DOTMA-CL)
  • 104872-42-6