Pramipexole impurity 7

Product Name: Pramipexole impurity 7
CAS No.: 106092-09-5
Chemical Name: Pramipexole impurity 7
Synonyms: Pramipexole-1;PraMipexole IMpurity A;PraMipexole IMpurity C;Pramipexole impurity I;Pramipexole Impurity A1;Paramipexole Impurity-A;Pramipexole Intermediate 1;pramipexole impurities1162;(S)-N-Despropyl PraMipexole;PraMipexole Related CoMpound A
CBNumber: CB0276708
Molecular Formula: C7H11N3S
Formula Weight: 169.25
MOL File: 106092-09-5.mol

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Pramipexole impurity 7 Property

Melting point:: 222-224°C
Boiling point:: 359.0±42.0 °C(Predicted)
Density: 1.313±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO (Slightly), Methanol (Slightly, Heated)
form: Solid
pka: 9.18±0.20(Predicted)
color: White to Pale Beige
optical activity: Consistent with structure
Stability:: Light Sensitive
InChI: InChI=1/C7H11N3S/c8-4-1-2-5-6(3-4)11-7(9)10-5/h4H,1-3,8H2,(H2,9,10)/t4-/s3
InChIKey: DRRYZHHKWSHHFT-BYPYZUCNSA-N
SMILES: NC1SC2C[C@@H](N)CCC=2N=1 |&1:5,r|
CAS DataBase Reference: 106092-09-5(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26
WGK Germany: 3
HS Code: 29349990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: PHR2010
Product name: Pramipexole Related Compound A
Purity: Pharmaceutical Secondary Standard; Certified Reference Material
Packaging: 50mg
Price: $631.75
Updated: 2025/07/31

Sigma-Aldrich

Product number: 757381
Product name: (S)-(?)-2,6-Diamino-4,5,6,7-tetrahydrobenzothiazole
Purity: 97%
Packaging: 1g
Price: $85.6
Updated: 2023/06/20

TCI Chemical

Product number: D4337
Product name: (S)-(-)-2,6-Diamino-4,5,6,7-tetrahydrobenzothiazole
Purity: >98.0%(GC)(T)
Packaging: 1g
Price: $67
Updated: 2025/07/31

TCI Chemical

Product number: D4337
Product name: (S)-(-)-2,6-Diamino-4,5,6,7-tetrahydrobenzothiazole
Purity: >98.0%(GC)(T)
Packaging: 5g
Price: $263
Updated: 2025/07/31

Sigma-Aldrich

Product number: 1553768
Product name: Pramipexole Related Compound A
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 15mg
Price: $1300
Updated: 2025/07/31

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Pramipexole impurity 7 Chemical Properties,Usage,Production

Chemical Properties

Pale Beige Solid

Uses

(S)-Pramipexole intermediate as dopamine autoreceptor agonist.

Uses

(S)-N-Despropyl Pramipexole (Pramipexole EP Impurity A; Pramipexole BP Impurity A; Pramipexole USP Related Compound A) is a (S)-Pramipexole (P700755) intermediate as dopamine autoreceptor agonist.

Uses

(S)-N-Despropyl Pramipexole is a (S)-Pramipexole (P700745) intermediate as dopamine autoreceptor agonist.

Synthesis

106006-83-1

106092-09-5

General procedure for the synthesis of (S)-2,6-diamino-4,5,6,7-tetrahydrobenzothiazole from 2,6-diamino-4,5,6,7-tetrahydrobenzothiazole: First, 33.8 g of 2,6-diamino-4,5,6,7-tetrahydrobenzothiazole was mixed with 500 mL of water, followed by the addition of 30.0 g of L-(+)-tartaric acid. The reaction mixture was heated to 75°C and stirred for 1 hour. Thereafter, it was cooled to room temperature and stirring was continued for 24 hours. After completion of the reaction, filtration was carried out, the precipitate was washed with water and dried under vacuum at 55°C to 65°C and -0.01 MPa to -0.1 MPa for 8-12 hours to afford 35.1 g of (S)-2,6-diamino-4,5,6,7-tetrahydrobenzothiazolium di-L-(+)-tartrate as crude product with an enantiomeric content of 2.53% (by chiral-HPLC determination). The entire crude product was redissolved in 500 mL of water, heated to 75°C and held for 1 hour, then cooled to room temperature and stirred for 24 hours. It was filtered again, washed with water and dried under the same vacuum conditions for 8-12 hours to give 26.9 g of (S)-2,6-diamino-4,5,6,7-tetrahydrobenzothiazolyl di-L-(+)-tartrate with enantiomeric content reduced to 0.08%. Finally, the entire product was dissolved in a mixture of 200 mL of water and 40 mL of hydrochloric acid and stirred until completely dissolved. Subsequently, 35 drops of aqueous potassium hydroxide solution (mass percent is the ratio of potassium hydroxide to the total mass of the solution) were added to neutralize. The reaction mixture was cooled to room temperature and stirred for 1 h. The reaction mixture was filtered, the precipitate was washed with water and dried under vacuum at 55°C to 65°C and -0.01 MPa to -0.1 MPa for 8-12 h. The final product was 9.43 g of (S)-2,6-diamino-4,5,6,7-tetrahydrobenzothiazole in a yield of 27.9% and enantiomeric content of 0.08%.

References

[1] Journal of Medicinal Chemistry, 2015, vol. 58, # 14, p. 5501 - 5521
[2] Patent: CN108084115, 2018, A. Location in patent: Paragraph 0086; 0089
[3] Journal of Medicinal Chemistry, 1987, vol. 30, # 3, p. 494 - 498
[4] Patent: WO2011/21214, 2011, A2
[5] Investigational New Drugs, 2010, vol. 28, # 4, p. 454 - 465

Pramipexole impurity 7 Preparation Products And Raw materials

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Preparation Products

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View Lastest Price from Pramipexole impurity 7 manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: (S)-4,5,6,7-Tetrahydro-2,6-benzothiazolediamine 106092-09-5
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-20

Hangzhou ICH Biofarm Co., Ltd

Product: (S)-4,5,6,7-Tetrahydro-2,6-benzothiazolediamine 106092-09-5
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99.0%min
Supply Ability: 5MT
Release date: 2023-06-14

Zhuozhou Wenxi import and Export Co., Ltd

Product: (S)-4,5,6,7-Tetrahydro-2,6-benzothiazolediamine 106092-09-5
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-08-11

106092-09-5, Pramipexole impurity 7Related Search:

Iminodiacetonitrile Diaminomaleonitrile 2-Mercaptobenzothiazole AMINOACETONITRILE HYDROGEN SULFATE Iminodiacetic acid 4,4'-Methylenedianiline Benzothiazole 2,2'-Dithiobis(benzothiazole) 2,6-diamino-4,5,6,7-tetrahydrobenzo[d]thiazol-7-ol Pemetrexed Impurity 1 Dabigatran Impurity 8 PeMetrexed EP IMpurity A Desethyl Dabigatran Etexilate PeMetrexed IMpurity D (R)-Pramipexole N6-propyl-3a,4,5,6,7,7a-hexahydrobenzo[d]thiazole-2,6-diamine Pramipexole EP Impurity E N-(Aminothioxomethyl)-5-oxo-1-propyl-2-pyrrolidineacetamide

(6S)-4,5,6,7-TETRAHYDRO-1,3-BENZOTHIAZOL-2,6-DIAMINE

(6S)-4,5,6,7-TETRAHYDRO-1,3-BENZOTHIAZOLE-2,6-DIAMINE

S-(-)-2,6-Diamino-4,5,6,7-tetrahydrobenzothiazole (6S)-2,6-Diamino-4,5,6,7-tetrahydrobenzothiazole

(6S)-2,6-Diamino-4,5,6,7-tetrahydrobenzothiazole

(-)-2,6-DIAMINO-4,5,6,7-TETRA-HYDROXYBENZOTHIAZOL

S-(-)-2,6-Diamino-4,5,6,7-tetrahydro-2,6-benzothiazole

(S)-2-Amino-4,5,6,7-tetrahydro-6-aminobenzothiazole

(S)-(-)-2,6-Diamino-4,5,6,7-tetrahydrobenzothiazole, 99%, ee: 99%

Pramipexole Impurity 1(Pramipexole EP Impurity A)

(s)-4,5,6,7-tetrahydro-2,6-benzothiazolediamine

(S)-4,5,6,7-TETRAHYDROBENZO[D]THIAZOLE-2,6-DIAMINE

(S)-4,5,6,7-TETRAHYDRO-BENZOTHIAZOLE-2,6-DIAMINE

S-(-)-2,6-Diamino-4,5,6,7-tetrahydrobenzothiazole

(-)-2,6-diamino-4,5,6,7-tetrahydroben thiazole

(-)-(6S)-2,6-Diamino-4,5,6-tetrahydrobenzothiazole

S(-) 2-Amino-6-amino-4,5,6,7-tetrahydro benzothiazole

Praxsol Hydrochloride Impurity A

4,5,6,7-tetrahydrobenzo[d]thiazole-2,6-diamine

Pramipexole Intermediate 1

(6S)-4,5,6,7-Tetrahydro-2,6-benzothiazolediamine

(S)-N-Despropyl PraMipexole

2,6-BenzothiazolediaMine,4,5,6,7-tetrahydro-,(6S)-

Pramipexole Related Compound A (15 mg) ((S)-4,5,6,7-Tetrahydrobenzothiazole-2,6-diamine)

PraMipexole EP IMpurity A (USP RC A)

PraMipexole IMpurity A

PraMipexole IMpurity C

(s)-4,5,6,7-tetrahydrobenzothiazole-2,6-diaMino

(-)-2,6-diaMino-4,5,6,7-tetrahydroben thiazo...

Pramipexole impurity I

Pramipexole Dihydrochloride Monohydrate EP Impurity A

PraMipexole Related CoMpound A

(s)-(-) 4,5,6,7-Tetrahydrobenzothiazole-2,6-diamine 95%

Pramipexole-1

(S)-(-)-2,6-Diamino-4,5,6,7-tetrahydrobenzothiazole&gt

Pramipexole Impurity A1

(S)-2,6-Diamino-4,5,6,7-tetrahydrobenzothiazoL

Paramipexole Impurity-A

pramipexole impurities1162

Pramipexole EP Impurity AQ: What is Pramipexole EP Impurity A Q: What is the CAS Number of Pramipexole EP Impurity A Q: What is the storage condition of Pramipexole EP Impurity A Q: What are the applications of Pramipexole EP Impurity A

Pramipexole Related Compound A ((S)-4,5,6,7-Tetrahydrobenzothiazole-2,6-diamine) (1553768)

Pramipexole USP Related Compound A

(6S)-4,5,6,7-Tetrahydro-2,6-benzodthiazolediamine

Pramipexole Dihydrochloride Monohydrate Impurity A

(<i>S</i>)-(?)-2,6-Diamino-4,5,6,7-tetrahydrobenzothiazole

(?)-(6S)-2,6-Diamino-4,5,6,7-tetrahydrobenzothiazole

(S)-4,5,6,7-Tetrahydro-benzo[d]thiazol-2,6-diamine

106092-09-5

06092-09-5

API

(intermediate of pramipexole)

intermidiate of Pramipexole

All Inhibitors

Inhibitors

Intermediates

Intermediates & Fine Chemicals

Pharmaceuticals

Pramipexole Dihydrochloride Monohydrate