ETHYL 2-AMINOOXAZOLE-4-CARBOXYLATE

Product Name: ETHYL 2-AMINOOXAZOLE-4-CARBOXYLATE
CAS No.: 177760-52-0
Chemical Name: ETHYL 2-AMINOOXAZOLE-4-CARBOXYLATE
Synonyms: CAS:177760-52-0;ETHYL 2-AMINOOXAZOLE-4-CARBOXYLATE;ETHYL 2-AMINO-4-OXAZOLECARBOXYLATE;Ethyl 2-amino-oxazol-4-carboxylate;Ethyl-2-aminooxalzole-4-carboxylate;2-Amino-4-(ethoxycarbonyl)-1,3-oxazole;Ethyl 2-amino-1,3-oxazole-4-carboxylate;2-AMinooxazole-4-carboxylate ethyl ester;2-Amino-4-oxazolecarboxylic Acid Ethyl Ester;2-AMINOOXAZOLE-4-CARBOXYLIC ACID ETHYL ESTER
CBNumber: CB0276773
Molecular Formula: C6H8N2O3
Formula Weight: 156.14
MOL File: 177760-52-0.mol

More

Less

ETHYL 2-AMINOOXAZOLE-4-CARBOXYLATE Property

Melting point:: 124-128
Boiling point:: 282.9±32.0 °C(Predicted)
Density: 1.278±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
pka: 2.82±0.10(Predicted)
form: solid
Appearance: Off-white to light yellow Solid
InChI: InChI=1S/C6H8N2O3/c1-2-10-5(9)4-3-11-6(7)8-4/h3H,2H2,1H3,(H2,7,8)
InChIKey: NBABLVASYFPOEV-UHFFFAOYSA-N
SMILES: O1C=C(C(OCC)=O)N=C1N
CAS DataBase Reference: 177760-52-0(CAS DataBase Reference)

More

Less

Safety

Hazard Codes: Xi
Safety Statements: 24/25
WGK Germany: 3
Hazard Note: Harmful/Irritant/Keep Cold
HazardClass: IRRITANT
HS Code: 29349990

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 750794
Product name: Ethyl 2-aminooxazole-4-carboxylate
Purity: 95%
Packaging: 5g
Price: $39.4
Updated: 2025/07/31

TRC

Product number: A618540
Product name: 2-Amino-4-oxazolecarboxylicAcidEthylEster
Packaging: 10g
Price: $470
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM1050717
Product name: 2-AMINOOXAZOLE-4-CARBOXYLIC ACID ETHYL ESTER
Purity: 95.00%
Packaging: 5G
Price: $845.34
Updated: 2021/12/16

Matrix Scientific

Product number: 057454
Product name: Ethyl 2-aminooxazole-4-carboxylate
Purity: 95%
Packaging: 5g
Price: $44
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H58-1-V3
Product name: Ethyl 2-amino-1,3-oxazole-4-carboxylate
Packaging: 5G
Price: $48
Updated: 2021/12/16

More

Less

ETHYL 2-AMINOOXAZOLE-4-CARBOXYLATE Chemical Properties,Usage,Production

Chemical Properties

Ethyl 2-aminooxazole-4-carboxylate is a carboxylate derivative that can undergo esterification reaction.

Uses

Ethyl 2-aminooxazole-4-carboxylate is an intermediate used in the preparation of inhibitors of Akt activity useful in the treatment of cancer and arthritis.

Synthesis

70-23-5

57-13-6

177760-52-0

General procedure for the synthesis of ethyl 2-aminooxazole-4-carboxylate from ethyl 3-bromopyruvate and urea: ethyl 3-bromopyruvate (50.2 g, 257.2 mmol) was dissolved in ethanol and urea (23.2 g, 385.8 mmol) was added with stirring. The reaction mixture was heated to reflux overnight. After completion of the reaction, the solvent was removed by concentration under reduced pressure. The obtained residue was dissolved in a solvent mixture of ethyl acetate and water to separate the organic and aqueous layers. The aqueous layer was extracted with ethyl acetate. All organic layers were combined, washed sequentially with saturated sodium chloride solution and dried over anhydrous magnesium sulfate. After filtration, the organic phase was concentrated under reduced pressure to afford the target product ethyl 2-aminooxazole-4-carboxylate in 85% yield. The structure of the product was confirmed by nuclear magnetic resonance (NMR) and mass spectrometry (MS) analyses.LCMS (ESI+) m/z: 157.1 ([M+H]+).

References

[1] Patent: US2009/23707, 2009, A1. Location in patent: Page/Page column 33-34
[2] Patent: WO2017/17631, 2017, A2. Location in patent: Paragraph 00382
[3] European Journal of Medicinal Chemistry, 2019, p. 80 - 108
[4] Patent: WO2007/146066, 2007, A2. Location in patent: Page/Page column 156-157
[5] Journal of Medicinal Chemistry, 2010, vol. 53, # 9, p. 3814 - 3830

ETHYL 2-AMINOOXAZOLE-4-CARBOXYLATE Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

ETHYL 2-AMINOOXAZOLE-4-CARBOXYLATE Suppliers

Canada 1 China 192 Europe 1 Germany 2 India 5 United Kingdom 5 United States 24 Global 230

Shanghai Jian Chao Chemical Technology Co., Ltd.

Tel: 150-2103-5486 18017383231
Fax: qq：2817624287
Email: 983544897@qq.com
Country: China
ProdList: 9342
Advantage: 55

Shaoyuan Technology (Shanghai) Co., Ltd.

Tel: 021-50795510 4000665055
Email: sy-c5@accelachem.com
Country: China
ProdList: 10000
Advantage: 58

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Alfa Aesar

Tel: 400-6106006
Fax: 021-67582001/03/05
Email: saleschina@alfa-asia.com
Country: China
ProdList: 30123
Advantage: 84

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44801
Advantage: 61

Wuhan Chemwish Technology Co., Ltd

Tel: 86-027-67849912
Fax: 86-027-87531808
Email: sales@chemwish.com
Country: China
ProdList: 35896
Advantage: 56

Capot Chemical Co., Ltd

Tel: +86 (0) 571 85 58 67 18
Fax: 0086-571-85864795
Country: China
ProdList: 18207
Advantage: 66

JinYan Chemicals(ShangHai) Co.,Ltd.

Tel: 13817811078
Fax: 86-021-50426522,50426273
Email: sales@jingyan-chemical.com
Country: China
ProdList: 9976
Advantage: 60

Jia Xing Isenchem Co.,Ltd

Tel: 0573-85285100 18627885956
Fax: 0573-85285100
Email: isenchem@163.com
Country: China
ProdList: 9310
Advantage: 66

Shanghai Yuanding Chem. Sci. & Tech. Co., Ltd.

Tel: 21-57721279
Fax: QQ：14057904
Email: sales@shydchem.com.cn
Country: China
ProdList: 998
Advantage: 56

More

Less

View Lastest Price from ETHYL 2-AMINOOXAZOLE-4-CARBOXYLATE manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: Ethyl 2-amino-1,3-oxazole-4-carboxylate 177760-52-0
Price: US $1.10-9.90/KG
Min. Order: 1KG
Purity: 99% min
Supply Ability: 100kg
Release date: 2025-08-18

Zhuozhou Wenxi import and Export Co., Ltd

Product: ETHYL 2-AMINOOXAZOLE-4-CARBOXYLATE 177760-52-0
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-08-11

Zhuozhou Wenxi import and Export Co., Ltd

Product: Ethyl 2-Aminooxazole-4-carboxylate 177760-52-0
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

177760-52-0, ETHYL 2-AMINOOXAZOLE-4-CARBOXYLATERelated Search:

ETHYL 2-CHLOROOXAZOLE-4-CARBOXYLATE 4-Oxazolecarboxylic acid, 2-amino-, ethyl ester ETHYL 2-AMINOOXAZOLE-5-CARBOXYLATE Ethyl 2-(t-BOC-amino)oxazole-5-carboxylate ETHYL 2-MORPHOLINOOXAZOLE-4-CARBOXYLATE 2- amino-1,3-oxazole-4-carboxylic acid ETHYL 2-AMINOOXAZOLE-4-CARBOXYLATE 4-Oxazolecarboxylic acid, 2-amino-5-bromo-, ethyl ester Ethyl 2-amino-1,3-thiazole-4-carboxylate Ethyl 2-aminothiazole-5-carboxylate

2-AMINOOXAZOLE-4-CARBOXYLIC ACID ETHYL ESTER

2-AMINOOXAZOLE-4-CARBOXYLIC ACID ETHYL ESTER, 95+%

Ethyl 2-amino-1,3-oxazole-4-carboxylate

4-Oxazolecarboxylicacid,2-amino-,ethylester(9CI)

2-AMinooxazole-4-carboxylate ethyl ester

2-AMino-1,3-Isoxazole-4-Carboxylic Acid Ethylester

2-Amino-4-oxazolecarboxylic Acid Ethyl Ester

ETHYL 2-AMINO-4-OXAZOLECARBOXYLATE

ETHYL 2-AMINOOXAZOLE-4-CARBOXYLATE

2-Amino-4-(ethoxycarbonyl)-1,3-oxazole

4-Oxazolecarboxylic acid, 2-amino-, ethyl ester

4-Oxazolecarboxylic acid, 2-amino-, ethyl ester (9CI, ACI)

2-amino-4-Oxazolecarboxylic acid ethyl ester (9CI ACI)

2-amino-1,3-Oxozole-4-carboxylic acid ethyl ester

CAS:177760-52-0

Ethyl-2-aminooxalzole-4-carboxylate

Ethyl 2-amino-oxazol-4-carboxylate

177760-52-0

Building Blocks

Chemical Synthesis

Heterocyclic Building Blocks

New Products for Chemical Synthesis

Oxazoles, Isoxazoles & Benzoxazoles

Esters

Oxazoles, Isoxazoles & Benzoxazoles

CARBOXYLICESTER

GLYCINESCAFFOLD

Amines

blocks

Carboxes

Oxazoles