ETHYL 2-CHLOROOXAZOLE-4-CARBOXYLATE

Product Name: ETHYL 2-CHLOROOXAZOLE-4-CARBOXYLATE
CAS No.: 460081-18-9
Chemical Name: ETHYL 2-CHLOROOXAZOLE-4-CARBOXYLATE
Synonyms: CAS:460081-18-9;Ethyl 2-chlorooxazole-4-c...;ETHYL 2-CHLOROOXAZOLE-4-CARBOXYLATE;2-CHLOROOXAZOLE-4-CARBOXYLIC ACID ETHYL;Ethyl 2-chloro-1,3-oxazole-4-carboxylate;2-CHLOROOXAZOLE-4-CARBOXYLIC ACID ETHYL ESTER;4-Oxazolecarboxylic acid, 2-chloro-, ethyl ester;2-Chloro-1,3-Oxazole-4-Carboxylic Acid Ethylester;4-Oxazolecarboxylicacid,2-chloro-,ethylester(9CI);2-chloro-1,3-Oxozole-4-carboxylic acid ethyl ester
CBNumber: CB9737655
Molecular Formula: C6H6ClNO3
Formula Weight: 175.57
MOL File: 460081-18-9.mol

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ETHYL 2-CHLOROOXAZOLE-4-CARBOXYLATE Property

Melting point:: 97-98℃
Boiling point:: 254.1±32.0 °C(Predicted)
Density: 1.332±0.06 g/cm3(Predicted)
storage temp.: Inert atmosphere,Store in freezer, under -20°C
pka: -3.20±0.10(Predicted)
Appearance: White to pink Solid
InChI: InChI=1S/C6H6ClNO3/c1-2-10-5(9)4-3-11-6(7)8-4/h3H,2H2,1H3
InChIKey: SYWQOPRAPDMWMC-UHFFFAOYSA-N
SMILES: O1C=C(C(OCC)=O)N=C1Cl
CAS DataBase Reference: 460081-18-9(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
HazardClass: IRRITANT
HS Code: 2934999090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TRC

Product number: E903623
Product name: Ethyl 2-chlorooxazole-4-carboxylate
Packaging: 250mg
Price: $55
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H23-5-W5
Product name: Ethyl 2-chloro-1,3-oxazole-4-carboxylate
Packaging: 1g
Price: $56
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0419858
Product name: 2-CHLOROOXAZOLE-4-CARBOXYLIC ACID ETHYL ESTER
Purity: 95.00%
Packaging: 250MG
Price: $642.99
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0419858
Product name: 2-CHLOROOXAZOLE-4-CARBOXYLIC ACID ETHYL ESTER
Purity: 95.00%
Packaging: 2.5G
Price: $1363.65
Updated: 2021/12/16

Apolloscientific

Product number: OR2874
Product name: Ethyl2-chloro-1,3-oxazole-4-carboxylate
Purity: 95%
Packaging: 1g
Price: $51
Updated: 2021/12/16

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ETHYL 2-CHLOROOXAZOLE-4-CARBOXYLATE Chemical Properties,Usage,Production

Synthesis

177760-52-0

460081-18-9

Under nitrogen protection, 1.70 mL (14.3 mmol) of tert-butyl nitrite was added dropwise to a suspension of 1.65 g (12.3 mmol) cuprous(I) chloride in 50 mL of acetonitrile. The reaction mixture was heated to 75 °C, followed by the addition of 1.60 g (10.2 mmol) of ethyl 2-aminooxazole-4-carboxylate in batches over 20 min (Ref: G Crank MJ Foulis, J Med Chem 1971,14:1075-1077). Gases were released during the reaction. After continued stirring for 30 min, the reaction mixture was cooled to room temperature, diluted with 50 mL of ethyl acetate and washed with water (2 x 25 mL). The organic layer was dried over anhydrous magnesium sulfate and concentrated under reduced pressure to give a dark oily solid. Purification by neutral silica gel column chromatography using a solvent mixture of hexane and ethyl acetate (3:1) afforded 1.27 g (71% yield) of the target compound, ethyl 2-chloroxazole-4-carboxylate, as white needle-like crystals (recrystallized from hexane). Mass spectrum (electrospray positive ion mode): m/z 176/177 [M+H]+. 1H NMR (CDCl3) δ: 1.47 (t, 3H, J = 7.16 Hz); 4.48 (q, 2H, J = 7.16 Hz); 8.28 (s, 1H).

References

[1] Organic Letters, 2003, vol. 5, # 16, p. 2911 - 2914
[2] Organic Letters, 2002, vol. 4, # 17, p. 2905 - 2907
[3] European Journal of Medicinal Chemistry, 2019, p. 80 - 108
[4] Patent: WO2005/26149, 2005, A1. Location in patent: Page/Page column 111
[5] Journal of Medicinal Chemistry, 2010, vol. 53, # 9, p. 3814 - 3830

ETHYL 2-CHLOROOXAZOLE-4-CARBOXYLATE Preparation Products And Raw materials

Raw materials

Preparation Products

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ETHYL 2-CHLOROOXAZOLE-4-CARBOXYLATE Suppliers

China 141 Europe 1 Germany 1 India 5 United Kingdom 5 United States 21 Global 174

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View Lastest Price from ETHYL 2-CHLOROOXAZOLE-4-CARBOXYLATE manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: Ethyl 2-chlorooxazole-4-carboxylate 460081-18-9
Price: US $1.10-9.90/KG
Min. Order: 1KG
Purity: 99% min
Supply Ability: 100kg
Release date: 2025-08-18

Career Henan Chemical Co

Product: ETHYL 2-CHLOROOXAZOLE-4-CARBOXYLATE 460081-18-9
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 100KG
Release date: 2018-08-20

460081-18-9, ETHYL 2-CHLOROOXAZOLE-4-CARBOXYLATERelated Search:

4-Oxazolecarboxylic acid, 2-amino-, ethyl ester ETHYL 2-AMINOOXAZOLE-4-CARBOXYLATE Ethyl 2-chlorooxazole-5-carboxylate (2-CHLOROOXAZOL-4-YL)METHANOL 2-Chlorooxazole-4-carboxylic acid 2-Chloroxazole ETHYL 2-CHLOROOXAZOLE-4-CARBOXYLATE

2-CHLOROOXAZOLE-4-CARBOXYLIC ACID ETHYL ESTER, 95+%

Ethyl 2-chlorooxazole-4-c...

2-Chloro-1,3-Oxazole-4-Carboxylic Acid Ethylester

2-CHLOROOXAZOLE-4-CARBOXYLIC ACID ETHYL

4-Oxazolecarboxylic acid, 2-chloro-, ethyl ester

ETHYL 2-CHLOROOXAZOLE-4-CARBOXYLATE

2-CHLOROOXAZOLE-4-CARBOXYLIC ACID ETHYL ESTER

Ethyl 2-chloro-1,3-oxazole-4-carboxylate

4-Oxazolecarboxylicacid,2-chloro-,ethylester(9CI)

Ethyl 2-chlorooxazole-4-carboxylatexazole-4-carboxylate

2-chloro-1,3-Oxozole-4-carboxylic acid ethyl ester

CAS:460081-18-9

460081-18-9

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