Ethyl 2-chloro-1,3-oxazole-5-carboxylate
- Product Name
- Ethyl 2-chloro-1,3-oxazole-5-carboxylate
- CAS No.
- 862599-47-1
- Chemical Name
- Ethyl 2-chloro-1,3-oxazole-5-carboxylate
- Synonyms
- Ethyl 2-chlorooxazole-5-carboxylate;2-Chloro-5-(ethoxycarbonyl)-1,3-oxazole;Ethyl 2-chloro-1,3-oxazole-5-carboxylate;Ethyl 2-chloro-1,3-oxazole-5-carboxylate 98%;5-Oxazolecarboxylic acid, 2-chloro-, ethyl ester
- CBNumber
- CB7958263
- Molecular Formula
- C6H6ClNO3
- Formula Weight
- 175.57
- MOL File
- 862599-47-1.mol
Ethyl 2-chloro-1,3-oxazole-5-carboxylate Property
- Boiling point:
- 254.1±32.0 °C(Predicted)
- Density
- 1.332±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Store in freezer, under -20°C
- pka
- -2?+-.0.10(Predicted)
- form
- liquid
- color
- Orange
- InChI
- InChI=1S/C6H6ClNO3/c1-2-10-5(9)4-3-8-6(7)11-4/h3H,2H2,1H3
- InChIKey
- ZFLDTEIDAGWEEI-UHFFFAOYSA-N
- SMILES
- O1C(C(OCC)=O)=CN=C1Cl
Safety
- Hazard Codes
- Xi
- Hazard Note
- Irritant/Keep Cold
- HS Code
- 2934999090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- E903778
- Product name
- Ethyl2-Chlorooxazole-5-carboxylate
- Packaging
- 500mg
- Price
- $155
- Updated
- 2021/12/16
- Product number
- 4H23-5-W3
- Product name
- Ethyl 2-chloro-1,3-oxazole-5-carboxylate
- Purity
- 96%
- Packaging
- 1g
- Price
- $225
- Updated
- 2021/12/16
- Product number
- 4H23-5-W3
- Product name
- Ethyl 2-chloro-1,3-oxazole-5-carboxylate
- Purity
- 96%
- Packaging
- 250mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- Y5588
- Product name
- Ethyl2-chlorooxazole-5-carboxylate
- Packaging
- 100mg
- Price
- $101
- Updated
- 2021/12/16
- Product number
- CM105102
- Product name
- ethyl2-chloro-1,3-oxazole-5-carboxylate
- Purity
- 97%
- Packaging
- 5g
- Price
- $314
- Updated
- 2021/12/16
Ethyl 2-chloro-1,3-oxazole-5-carboxylate Chemical Properties,Usage,Production
Synthesis
118994-89-1
862599-47-1
General procedure for the synthesis of ethyl 2-chlorooxazole-5-carboxylate from ethyl oxazole-5-carboxylate: to a solution of ethyl oxazole-5-carboxylate (15.0 g, 106 mmol) in tetrahydrofuran (THF, 150 mL) was added slowly and dropwise to a solution of lithium hexamethyldisilanamide (LiHMDS, 178 mL, 170 mmol) at -60 °C. The reaction mixture was stirred continuously at -50 °C for 1 hour. Subsequently, hexachloroethane (37.8 g, 160 mmol) was added to the reaction system. The reaction mixture was warmed to room temperature and stirred for 12 hours. Upon completion of the reaction, the reaction was quenched with saturated aqueous ammonium chloride (NH4Cl) solution (50 mL) and subsequently extracted with ethyl acetate (EtOAc, 50 mL). The organic layer was separated, dried over anhydrous sodium sulfate (Na2SO4) and concentrated under reduced pressure. The residue was purified by column chromatography to afford the target product ethyl 2-chlorooxazole-5-carboxylate (10 g, 56% yield) as a colorless oil.1H NMR (400 MHz, CDCl3) δ 7.71 (s, 1H), 3.39 (q, J=7.2 Hz, 2H), 1.38 (t, J=7.2 Hz, 3H).
References
[1] Organic Letters, 2005, vol. 7, # 15, p. 3351 - 3354
[2] Patent: WO2015/116663, 2015, A1. Location in patent: Paragraph 0116
Ethyl 2-chloro-1,3-oxazole-5-carboxylate Preparation Products And Raw materials
Raw materials
Preparation Products
Ethyl 2-chloro-1,3-oxazole-5-carboxylate Suppliers
- Tel
- 18993966060
- Fax
- 0943-8288977
- sales@techbiochem.com
- Country
- China
- ProdList
- 806
- Advantage
- 61
- Tel
- 021-50795510 4000665055
- sy-c6@accelachem.com
- Country
- China
- ProdList
- 10000
- Advantage
- 58
- Tel
- 025-86918202 4000255188
- Fax
- 86-025-86918232
- sales@pharmablock.com
- Country
- China
- ProdList
- 5000
- Advantage
- 55
- Tel
- 021-021-58432009 400-005-6266
- Fax
- 021-58436166
- sales8178@energy-chemical.com
- Country
- China
- ProdList
- 44801
- Advantage
- 61
- Tel
- 86-027-67849912
- Fax
- 86-027-87531808
- sales@chemwish.com
- Country
- China
- ProdList
- 35896
- Advantage
- 56
- Tel
- 13526569071
- sales@leadmedpharm.com
- Country
- China
- ProdList
- 7892
- Advantage
- 64
- Tel
- 10-61256048 13810278579
- Fax
- +86 10 61256049
- sales@zeroschem.com
- Country
- China
- ProdList
- 1371
- Advantage
- 59
- Tel
- 15921303235
- Fax
- QQ489466966
- sales@synthfine.com
- Country
- China
- ProdList
- 1041
- Advantage
- 58
- Tel
- 0931-4190454 13893344397
- Fax
- +86-931-8506154
- sales@kyxpharma.com
- Country
- China
- ProdList
- 310
- Advantage
- 55
- Tel
- 18652989687
- Fax
- +86-25-52131256
- sales@norris-pharm.com
- Country
- China
- ProdList
- 8878
- Advantage
- 55
View Lastest Price from Ethyl 2-chloro-1,3-oxazole-5-carboxylate manufacturers
- Product
- ethyl 2-chlorooxazole-5-carboxylate 862599-47-1
- Price
- US $0.00/KG
- Min. Order
- 0.0001KG
- Purity
- 98%min
- Supply Ability
- 100kgs/month
- Release date
- 2022-05-10
- Product
- Ethyl 2-chloro-1,3-oxazole-5-carboxylate 862599-47-1
- Price
- US $1.00/g
- Min. Order
- 100g
- Purity
- 99%
- Supply Ability
- G/KG/T
- Release date
- 2019-12-20