METHYL ISOXAZOLE-5-CARBOXYLATE

Product Name: METHYL ISOXAZOLE-5-CARBOXYLATE
CAS No.: 15055-81-9
Chemical Name: METHYL ISOXAZOLE-5-CARBOXYLATE
Synonyms: AKOS PAO-1372;methyl 5-isoxazolcarboxylate;methyl oxazole-5-carboxylate;METHYL ISOXAZOLE-5-CARBOXYLATE;methyl 1,2-oxazole-5-carboxylate;5-Isoxazolecarboxylic acid, Methyl ester;ISOXAZOLE-5-CARBOXYLIC ACID METHYL ESTER;methyl isoxazole-5-carboxylate - [M83091];Isoxazole-5-carboxylic acid ethyl ester;Methyl 1,2-oxazole-5-carboxylate, 5-(Methoxycarbonyl)isozazole
CBNumber: CB3191387
Molecular Formula: C5H5NO3
Formula Weight: 127.1
MOL File: 15055-81-9.mol

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METHYL ISOXAZOLE-5-CARBOXYLATE Property

Melting point:: 48-51
Boiling point:: 203.9±13.0 °C(Predicted)
Density: 1.229±0.06 g/cm3(Predicted)
storage temp.: Store at room temperature
pka: -3.88±0.50(Predicted)
Appearance: Off-white to light brown Solid

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Safety

Hazard Codes: Xi
Safety Statements: 22-24/25
Hazard Note: Irritant
HS Code: 2934999090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: I918115
Product name: 5-IsoxazolecarboxylicAcidMethylEster
Packaging: 1g
Price: $140
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H23-1-72
Product name: Methyl isoxazole-5-carboxylate
Packaging: 5G
Price: $336
Updated: 2021/12/16

AK Scientific

Product number: W3292
Product name: Methylisoxazole-5-carboxylate
Packaging: 25g
Price: $1171
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H23-1-72
Product name: Methyl isoxazole-5-carboxylate
Packaging: 1g
Price: $104
Updated: 2021/12/16

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METHYL ISOXAZOLE-5-CARBOXYLATE Chemical Properties,Usage,Production

Uses

5-Isoxazolecarboxylic Acid Methyl Ester is used as a reagent in the synthesis of pyridine derivatives as integrase inhibitors and antiviral agents. 5-Isoxazolecarboxylic Acid Methyl Ester is also a useful synthetic intermediate in the preparation of pyrazolopyrimidine derivatives useful in the prevention and treatment of cancer.

Synthesis

21169-71-1

74-88-4

15055-81-9

A mixture of isoxazole-5-carboxylic acid (2.5 g, 22.1 mmol), sodium bicarbonate (5.57 g, 66.32 mmol) and iodomethane (8.26 mL, 132.65 mmol) in N,N-dimethylformamide (DMF, 30 mL) was stirred and reacted for 19 hr at 25 °C. After completion of the reaction, the mixture was diluted with deionized water (30 mL) and extracted with ether (2 × 50 mL). The combined organic layers were washed with saturated saline, dried over anhydrous magnesium sulfate, filtered and concentrated under reduced pressure to give the crude product. The crude product was purified by a Biotage fast chromatography system (40 m column) with the eluent of ethyl acetate-hexane (1:2, v/v), followed by switching to pure ethyl acetate, resulting in methyl isoxazole-5-carboxylate as an amorphous solid (1.2 g, 42.7% yield). Mass spectrum (+ESI): m/z 128 [M+H]+.

References

[1] Patent: US2007/219186, 2007, A1. Location in patent: Page/Page column 51

METHYL ISOXAZOLE-5-CARBOXYLATE Preparation Products And Raw materials

Raw materials

Preparation Products

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METHYL ISOXAZOLE-5-CARBOXYLATE Suppliers

Austria 1 China 70 Germany 3 India 2 Slovakia 1 Switzerland 2 United Kingdom 4 United States 7 Global 90

Alfa Aesar

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Energy Chemical

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China DongFan Chemical Co.,LTD

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Syntechem Co.,Ltd

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Hangzhou Sage Chemical Co., Ltd.

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Shanghai Fengchen Chem Co., Ltd.

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View Lastest Price from METHYL ISOXAZOLE-5-CARBOXYLATE manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: METHYL ISOXAZOLE-5-CARBOXYLATE 15055-81-9
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20 mt
Release date: 2024-11-18

Career Henan Chemical Co

Product: METHYL ISOXAZOLE-5-CARBOXYLATE 15055-81-9
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 200kgs
Release date: 2020-01-28

15055-81-9, METHYL ISOXAZOLE-5-CARBOXYLATERelated Search:

Isoxazole 5-Isoxazolecarboxylicacid,ethylester(9CI) ISOXAZOLE-4-CARBOXYLIC ACID ETHYL ESTER Isoxazol-4-ylmethanamine oxalate ISOXAFLUTOLE ISOXAZOLO[5,4-B]PYRIDIN-3-YLAMINE ISOXAZOLE-5-CARBOXYLIC ACID ISOXAZOLIDIN-3-ONE 1,2-oxazol-3-ylMethanaMine hydrochloride 3-AMINOISOXAZOLO[4,5-B]PYRAZINE Isoxazole-4-boronicacid C-ISOXAZOL-5-YL-METHYLAMINE HYDROCHLORIDE 4-Aminoisoxazole C-ISOXAZOL-4-YL-METHYLAMINE HYDROCHLORIDE ISOXAZOLE-3-CARBONITRILE Isoxazolo[5,4-c]pyridin-3-amine (9CI) isoxazol-3-yl-acetic acid 4-HYDROXYMETHYL-ISOXAZOLE

AKOS PAO-1372

ISOXAZOLE-5-CARBOXYLIC ACID METHYL ESTER

METHYL ISOXAZOLE-5-CARBOXYLATE

Isoxazole-5-carboxylic acid ethyl ester

methyl oxazole-5-carboxylate

5-Isoxazolecarboxylic acid, Methyl ester

Methyl 1,2-oxazole-5-carboxylate, 5-(Methoxycarbonyl)isozazole

methyl 1,2-oxazole-5-carboxylate

methyl 5-isoxazolcarboxylate

methyl isoxazole-5-carboxylate - [M83091]

15055-81-9