ChemicalBook > CAS DataBase List > METHYL ISOXAZOLE-5-CARBOXYLATE

METHYL ISOXAZOLE-5-CARBOXYLATE

Product Name: METHYL ISOXAZOLE-5-CARBOXYLATE
CAS No.: 15055-81-9
Chemical Name: METHYL ISOXAZOLE-5-CARBOXYLATE
Synonyms: AKOS PAO-1372;methyl 5-isoxazolcarboxylate;methyl oxazole-5-carboxylate;METHYL ISOXAZOLE-5-CARBOXYLATE;methyl 1,2-oxazole-5-carboxylate;5-Isoxazolecarboxylic acid, Methyl ester;ISOXAZOLE-5-CARBOXYLIC ACID METHYL ESTER;methyl isoxazole-5-carboxylate - [M83091];Isoxazole-5-carboxylic acid ethyl ester;Methyl 1,2-oxazole-5-carboxylate, 5-(Methoxycarbonyl)isozazole
CBNumber: CB3191387
Molecular Formula: C5H5NO3
Formula Weight: 127.1
MOL File: 15055-81-9.mol

Less

METHYL ISOXAZOLE-5-CARBOXYLATE Property

Melting point:: 48-51
Boiling point:: 203.9±13.0 °C(Predicted)
Density: 1.229±0.06 g/cm3(Predicted)
storage temp.: Store at room temperature
pka: -3.88±0.50(Predicted)
Appearance: Off-white to light brown Solid

Less

Safety

Hazard Codes: Xi
Safety Statements: 22-24/25
Hazard Note: Irritant
HS Code: 2934999090

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Less

N-Bromosuccinimide Price

TRC

Product number: I918115
Product name: 5-IsoxazolecarboxylicAcidMethylEster
Packaging: 1g
Price: $140
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H23-1-72
Product name: Methyl isoxazole-5-carboxylate
Packaging: 5G
Price: $336
Updated: 2021/12/16

AK Scientific

Product number: W3292
Product name: Methylisoxazole-5-carboxylate
Packaging: 25g
Price: $1171
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H23-1-72
Product name: Methyl isoxazole-5-carboxylate
Packaging: 1g
Price: $104
Updated: 2021/12/16

Less

METHYL ISOXAZOLE-5-CARBOXYLATE Chemical Properties,Usage,Production

Uses

5-Isoxazolecarboxylic Acid Methyl Ester is used as a reagent in the synthesis of pyridine derivatives as integrase inhibitors and antiviral agents. 5-Isoxazolecarboxylic Acid Methyl Ester is also a useful synthetic intermediate in the preparation of pyrazolopyrimidine derivatives useful in the prevention and treatment of cancer.

Synthesis

21169-71-1

74-88-4

15055-81-9

A mixture of isoxazole-5-carboxylic acid (2.5 g, 22.1 mmol), sodium bicarbonate (5.57 g, 66.32 mmol) and iodomethane (8.26 mL, 132.65 mmol) in N,N-dimethylformamide (DMF, 30 mL) was stirred and reacted for 19 hr at 25 °C. After completion of the reaction, the mixture was diluted with deionized water (30 mL) and extracted with ether (2 × 50 mL). The combined organic layers were washed with saturated saline, dried over anhydrous magnesium sulfate, filtered and concentrated under reduced pressure to give the crude product. The crude product was purified by a Biotage fast chromatography system (40 m column) with the eluent of ethyl acetate-hexane (1:2, v/v), followed by switching to pure ethyl acetate, resulting in methyl isoxazole-5-carboxylate as an amorphous solid (1.2 g, 42.7% yield). Mass spectrum (+ESI): m/z 128 [M+H]+.

References

[1] Patent: US2007/219186, 2007, A1. Location in patent: Page/Page column 51

METHYL ISOXAZOLE-5-CARBOXYLATE Preparation Products And Raw materials

Raw materials

Preparation Products

Less

METHYL ISOXAZOLE-5-CARBOXYLATE Suppliers

Austria 1 China 70 Germany 3 India 2 Slovakia 1 Switzerland 2 United Kingdom 4 United States 7 Global 90

Alfa Aesar

Tel: 400-6106006
Fax: 021-67582001/03/05
Email: saleschina@alfa-asia.com
Country: China
ProdList: 30123
Advantage: 84

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44801
Advantage: 61

China DongFan Chemical Co.,LTD

Tel: 86-0571-85151182
Fax: 86-0571-85151182
Country: China
ProdList: 5691
Advantage: 66

Syntechem Co.,Ltd

Tel
Fax: E-Mail Inquiry
Email: info@syntechem.com
Country: China
ProdList: 12984
Advantage: 57

Hangzhou Sage Chemical Co., Ltd.

Tel: +86057186818502 13588463833
Fax: Pls mail us for more information!
Email: info@sagechem.com
Country: China
ProdList: 10266
Advantage: 58

Nanjing Norris-Pharm Technology Co., Ltd

Tel: 18652989687
Fax: +86-25-52131256
Email: sales@norris-pharm.com
Country: China
ProdList: 8878
Advantage: 55

Shanghai Fengchen Chem Co., Ltd.

Tel: +86 (21) 13764690794 657056093
Fax: +86 (21) 33321990
Email: sales@shfcchem.com
Country: China
ProdList: 95
Advantage: 58

Shanghai Carlow Chemicals Co., Ltd.

Tel: 21-33526724 18930996265
Fax: 37023730
Email: info@carlowchem.com
Country: China
ProdList: 1922
Advantage: 58

Wuhan Chemduro Pharm Tech Co. Ltd.

Tel: 18040571231/1402788087
Fax: sales@chemduro.com
Country: China
ProdList: 1973
Advantage: 58

Shanghai HuanChuan Industry Co.,Ltd.

Tel: 021-61478794
Fax: 021-61478794
Email: sales@hcshhai.com
Country: China
ProdList: 9793
Advantage: 50

Anhui CONO Fine Chemical Co., Ltd.

Tel: 0550-0550-7097550 15051613561
Fax: 0550-7097550
Email: sales@ahknchem.com
Country: China
ProdList: 221
Advantage: 60

Shanghai Send Pharmaceutical Technology Co., Ltd.

Tel: 021-58088081 Q2635253576
Fax: QQ3382968513
Email: hailey@shsendpharm.com
Country: China
ProdList: 1984
Advantage: 55

Codow Chemical Co.,Ltd.

Tel: 18620099427
Fax: +86-20-62619665
Email: amy@howeipharm.com
Country: China
ProdList: 6687
Advantage: 55

Shanghai Qiao Chemical Science Co., Ltd

Tel: 021-58892003
Email: info@qiaochem.com
Country: China
ProdList: 6059
Advantage: 65

Shanghai Anmike Chemical Co. Ltd.

Tel: 微信 17321281695 18019252918
Fax: 021-31261685
Email: sale@amkchem.com
Country: China
ProdList: 9519
Advantage: 55

Aikon International Limited

Tel: 025-58859352 18068836627
Fax: (5)02557626880
Email: dt3@aikonchem.com
Country: China
ProdList: 15493
Advantage: 58

Henan Alfa Chemical Co., Ltd

Tel: +8615838112936
Email: alfa10@alfachem.cn
Country: China
ProdList: 12921
Advantage: 58

Hefei TNJ Chemical Industry Co.,Ltd.

Tel: +86-0551-65418671 +8618949823763
Fax: 0551-65418697
Email: sales@tnjchem.com
Country: China
ProdList: 34563
Advantage: 58

Blocksynth Pharmaceutical Technology Co.,Ltd

Tel: 0086-19817745290; +8619817745290
Email: bd@blocksynth.com
Country: China
ProdList: 5661
Advantage: 58

Dayang Chem (Hangzhou) Co.,Ltd.

Tel: +86-0571-88938639 +8617705817739
Fax: +86-571-88938652，+86-571- 88492614
Email: info@dycnchem.com
Country: China
ProdList: 52846
Advantage: 58

Hebei Chuanghai Biotechnology Co., Ltd

Tel: +8615350571055
Fax: whatapp+8619930503282
Email: Sibel@chuanghaibio.com
Country: China
ProdList: 8768
Advantage: 58

Accela ChemBio Co.,Ltd.

Tel: 021-50795510 4000665055
Email: sales@accelachem.com
Country: China
ProdList: 10467
Advantage: 58

Chengdu Feibo Pharm Technology Co., Ltd

Tel: +86 028-84641798 15982321820
Email: abby@arkpharm.com
Country: China
ProdList: 10000
Advantage: 58

Changzhou Yinghao Technology Development Co., Ltd

Tel: 15151934985
Email: sales@yingsapharm.com
Country: China
ProdList: 5173
Advantage: 58

Qi Qi hang Biotechnology Co., Ltd.

Tel: 18151111370
Email: 1046215251@qq.com
Country: China
ProdList: 5999
Advantage: 58

CONIER CHEM AND PHARMA LIMITED

Tel: +8618523575427
Email: sales@conier.com
Country: China
ProdList: 49975
Advantage: 58

career henan chemical co

Tel: +86-0371-86658258 +8613203830695
Fax: 0086-371-86658258
Email: factory@coreychem.com
Country: China
ProdList: 29798
Advantage: 58

Changzhou Kechem Bio-Scientific Co., LTD.

Tel: 0519-68985668 13685222090
Fax: qq735434464
Email: sales@kechem.cn
Country: China
ProdList: 26028
Advantage: 58

TCI (Shanghai) Chemical Trading Co., Ltd.

Tel: 021-61109150
Fax: 021-61105897
Email: sales@tcisct.com
Country: China
ProdList: 29668
Advantage: 58

Beijing Jin Ming Biotechnology Co., Ltd.

Tel: 010-60605840 15801484223;
Email: psaitong@jm-bio.com
Country: China
ProdList: 29757
Advantage: 58

Shaanxi Dideu Medichem Co. Ltd

Tel: 029-81124267 17392282731
Fax: 029-88380327
Email: 1073@dideu.com
Country: China
ProdList: 9992
Advantage: 58

Shanghai Haohong Pharmaceutical Co., Ltd.

Tel: 400-8210725 4008210725
Email: malulu@leyan.com
Country: China
ProdList: 40000
Advantage: 58

PharmaBlock Sciences (Nanjing), Inc.

Tel: 4000255188
Fax: 025 86918232
Email: sales_china@pharmablock.com
Country: China
ProdList: 10000
Advantage: 58

Bide Pharmatech Ltd.

Tel: 400-1647117 13681763483
Email: product02@bidepharm.com
Country: China
ProdList: 59936
Advantage: 58

Henan Evonik Biotechnology Co. LTD

Tel: 15672878902
Email: hnyingchuang@163.com
Country: China
ProdList: 3905
Advantage: 58

Zhengzhou Converging Chemical Co. LTD

Tel: 0371-53399770 18037166334
Email: 2853031800@qq.com
Country: China
ProdList: 5891
Advantage: 58

Shanghai Jianchao Biotechnology Co., LTD

Tel: 15021035486 18081542813
Email: 1804873256@qq.com
Country: China
ProdList: 6684
Advantage: 58

Yanggu Rongke Trading Co., Ltd

Tel: 15863541132
Email: 18366413387@163.com
Country: China
ProdList: 3898
Advantage: 58

Shanghai Titan Enterprise Development Co., Ltd

Tel: 16621224781
Email: syy@titansci.com
Country: China
ProdList: 2896
Advantage: 58

Ningbo Zhenyue Pharmaceutical Technology Co., Ltd

Tel: 19817745290
Email: bd@blocksynth.com
Country: China
ProdList: 5870
Advantage: 58

Jiangsu Watson Bio Ltd

Tel: 0512-81863996 13773182657;
Email: sales@watson.bio
Country: China
ProdList: 183
Advantage: 58

Heze Xingda Pharmaceutical Technology Co., Ltd.

Tel: 13583079096
Email: 18366413387@163.com
Country: China
ProdList: 3881
Advantage: 58

Santa Cruz Biotechnology Inc

Tel: 021-60936350
Email: scbt@scbt.com
Country: China
ProdList: 6594
Advantage: 58

Bejing Famous Pharmaceutical Technology Co., Ltd.

Tel: 15811073878
Email: sales@peking-pharmacy.com
Country: China
ProdList: 6297
Advantage: 58

XIAMEN AMITY INDUSTRY AND TRADE CO., LTD.

Tel: +8618950047208
Email: ellena@amitychem.com
Country: China
ProdList: 43416
Advantage: 58

Suzhou ARTK Medchem Co., Ltd.

Tel: +86-512-68323658 +86-18168183658
Email: sales1@artkmedchem.com
Country: China
ProdList: 39002
Advantage: 58

Jilin Chinese Academy of Sciences-yanshen Technology

Tel: +undefined18143011203
Email: info@chemextension.com
Country: China
ProdList: 42056
Advantage: 58

GIHI CHEMICALS CO.,LIMITED

Tel: +8618058761490
Email: info@gihichemicals.com
Country: China
ProdList: 49934
Advantage: 58

PT CHEM GROUP LIMITED

Tel: +86-85511178;
Email: peter68@ptchemgroup.com
Country: China
ProdList: 35425
Advantage: 58

Hangzhou MolCore BioPharmatech Co.,Ltd.

Tel: +86-057181025280; +8617767106207
Fax: 0571-85806285
Email: sales@molcore.com
Country: China
ProdList: 49734
Advantage: 58

Less

View Lastest Price from METHYL ISOXAZOLE-5-CARBOXYLATE manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: METHYL ISOXAZOLE-5-CARBOXYLATE 15055-81-9
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20 mt
Release date: 2024-11-18

Career Henan Chemical Co

Product: METHYL ISOXAZOLE-5-CARBOXYLATE 15055-81-9
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 200kgs
Release date: 2020-01-28

15055-81-9, METHYL ISOXAZOLE-5-CARBOXYLATERelated Search:

Isoxazole 5-Isoxazolecarboxylicacid,ethylester(9CI) ISOXAZOLE-4-CARBOXYLIC ACID ETHYL ESTER Isoxazol-4-ylmethanamine oxalate ISOXAFLUTOLE ISOXAZOLO[5,4-B]PYRIDIN-3-YLAMINE ISOXAZOLE-5-CARBOXYLIC ACID ISOXAZOLIDIN-3-ONE 1,2-oxazol-3-ylMethanaMine hydrochloride 3-AMINOISOXAZOLO[4,5-B]PYRAZINE Isoxazole-4-boronicacid C-ISOXAZOL-5-YL-METHYLAMINE HYDROCHLORIDE 4-Aminoisoxazole C-ISOXAZOL-4-YL-METHYLAMINE HYDROCHLORIDE ISOXAZOLE-3-CARBONITRILE Isoxazolo[5,4-c]pyridin-3-amine (9CI) isoxazol-3-yl-acetic acid 4-HYDROXYMETHYL-ISOXAZOLE

AKOS PAO-1372

ISOXAZOLE-5-CARBOXYLIC ACID METHYL ESTER

METHYL ISOXAZOLE-5-CARBOXYLATE

Isoxazole-5-carboxylic acid ethyl ester

methyl oxazole-5-carboxylate

5-Isoxazolecarboxylic acid, Methyl ester

Methyl 1,2-oxazole-5-carboxylate, 5-(Methoxycarbonyl)isozazole

methyl 1,2-oxazole-5-carboxylate

methyl 5-isoxazolcarboxylate

methyl isoxazole-5-carboxylate - [M83091]

15055-81-9