Ethyl 2-aminothiazole-5-carboxylate

Product Name: Ethyl 2-aminothiazole-5-carboxylate
CAS No.: 32955-21-8
Chemical Name: Ethyl 2-aminothiazole-5-carboxylate
Synonyms: BUTTPARK 77\50-04;RARECHEM AL BI 1263;2-aMinothiazole-5-Ethyl;ETHYL 2-AMINO-5-CARBOXLATE;2-aMino-5-thiazolecarboxylate;Ethyl-2-aminothiazole-5-carbonylate;ETHYL 2-AMINOTHIAZOLE-5-CARBOXYLATE;Ethyl 2-amino-5-thiazolecarboxylate;ethyl 2-Aminothiozole-5-carboxylate;2-AMINOTHIAZOLE-5-ETHYL CARBOXYLATE
CBNumber: CB8303716
Molecular Formula: C6H8N2O2S
Formula Weight: 172.2
MOL File: 32955-21-8.mol

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Ethyl 2-aminothiazole-5-carboxylate Property

Melting point:: 144-148
Boiling point:: 308.0±15.0 °C(Predicted)
Density: 1.336±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
Water Solubility: Insoluble in water
form: powder to crystal
pka: 3.12±0.10(Predicted)
color: White to Yellow to Orange
Sensitive: Moisture & Light Sensitive
λmax: 299nm(EtOH)(lit.)
InChI: InChI=1S/C6H8N2O2S/c1-2-10-5(9)4-3-8-6(7)11-4/h3H,2H2,1H3,(H2,7,8)
InChIKey: VNZXERIGKZNEKB-UHFFFAOYSA-N
SMILES: S1C(C(OCC)=O)=CN=C1N
CAS DataBase Reference: 32955-21-8(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36/37/39
WGK Germany: 2
HazardClass: IRRITANT
HS Code: 29339900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 708437
Product name: Ethyl 2-aminothiazole-5-carboxylate
Purity: 97%
Packaging: 5g
Price: $132
Updated: 2025/07/31

Sigma-Aldrich

Product number: 708437
Product name: Ethyl 2-aminothiazole-5-carboxylate
Purity: 97%
Packaging: 1g
Price: $54
Updated: 2023/06/20

TCI Chemical

Product number: E0907
Product name: Ethyl 2-Aminothiazole-5-carboxylate
Purity: >97.0%(HPLC)(T)
Packaging: 1g
Price: $33
Updated: 2025/07/31

TCI Chemical

Product number: E0907
Product name: Ethyl 2-Aminothiazole-5-carboxylate
Purity: >97.0%(HPLC)(T)
Packaging: 5g
Price: $38
Updated: 2025/07/31

TRC

Product number: A630420
Product name: 2-Amino-5-thiazolecarboxylicAcidEthylEster
Packaging: 2.5g
Price: $120
Updated: 2021/12/16

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Ethyl 2-aminothiazole-5-carboxylate Chemical Properties,Usage,Production

Chemical Properties

White to yellow or light brown crystal or powder

Uses

2-Amino-5-thiazolecarboxylic Acid Ethyl Ester is used in the synthesis of dual-action antidiabetic agents that inhibit glycogen phosphorylase.

Synthesis Reference(s)

Tetrahedron Letters, 42, p. 2101, 2001 DOI: 10.1016/S0040-4039(01)00161-7

Synthesis

1001-26-9

17356-08-0

32955-21-8

1. N-bromosuccinimide (19.6 g, 0.11 mol) was slowly added to a water/dioxane (1:1, 100 mL) solution of ethyl 3-ethoxyacrylate (14.4 g, 0.1 mol) at -10 °C. 2. The reaction mixture was stirred at room temperature for 1 h. 3. After the addition of thiourea (7.6 g, 0.1 mol), the reaction mixture was was heated to 80 °C and maintained for 1 h. 4. Upon completion of the reaction, the solution was cooled to room temperature followed by the addition of ammonia (20 mL). 5. The resulting paste was stirred at room temperature for 10 min and then filtered. 6. The filter cake was washed with water and dried under vacuum to give the final product, ethyl 2-aminothiazole-5-carboxylate (12.1 g, 70% yield).

References

[1] Patent: EP2615092, 2013, A1. Location in patent: Paragraph 0095; 0096
[2] Patent: WO2006/8556, 2006, A1. Location in patent: Page/Page column 20-21

Ethyl 2-aminothiazole-5-carboxylate Preparation Products And Raw materials

Raw materials

Ammonium hydroxide Ethanol Ethyl formate Sodium sulfate Sodium Sodium ethoxide Diethyl ether Hydrochloric acid Magnesium Potassium Ethyl chloroacetate Thiourea

Preparation Products

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Ethyl 2-aminothiazole-5-carboxylate Suppliers

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View Lastest Price from Ethyl 2-aminothiazole-5-carboxylate manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Ethyl 2-aminothiazole-5-carboxylate 32955-21-8
Price: US $0.00-0.00/Kg/Bag
Min. Order: 100g
Purity: 98%min
Supply Ability: 500kg
Release date: 2021-09-11

Henan Aochuang Chemical Co.,Ltd.

Product: Ethyl 2-aminothiazole-5-carboxylate 32955-21-8
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1ton
Release date: 2022-10-10

Suzhou Nordica Biopharma CO.,LTD

Product: Ethyl 2-aminothiazole-5-carboxylate 32955-21-8
Price: US $0.00-0.00/kg
Min. Order: 0.1kg
Purity: 99%
Supply Ability: 5 tons
Release date: 2024-11-15

32955-21-8, Ethyl 2-aminothiazole-5-carboxylateRelated Search:

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BUTTPARK 77\50-04

RARECHEM AL BI 1263

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ETHYL 2-AMINO-1,3-THIAZOLE-5-CARBOXYLATE HYDROBROMIDE

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ethyl 2-Aminothiozole-5-carboxylate

Ethyl2-Aminothiazole-5-carboxylate&gt

TIANFUCHEM-- 32955-21-8 -- Ethyl 2-aminothiazole-5-carboxylate in stock

5-Thiazolecarboxylic acid, 2-amino-, ethyl ester (6CI, 9CI, ACI)

2-amino-5-Thiazolecarboxylic acid ethyl ester (6CI 9CI ACI)

2-AMINOTHIAZOLE-5-ETHYL CARBOXYLATE

Ethyl 2-amino-thiazol-5-carboxylate

32955-21-8

2955-21-8

32995-21-8

32599-21-8

Amines and Anilines

Heterocycles

Carboxes

Thiazoles

Thiazole series

Thiazole

Heterocycle intermediates

Amines

blocks