6-methoxy-1-tetralone

Product Name: 6-methoxy-1-tetralone
CAS No.: 1078-19-9
Chemical Name: 6-methoxy-1-tetralone
Synonyms: 6-Methoxy-3,4-dihydronaphthalen-1(2H)-one;6-METHOXY-1-TETRALONE;1(2H)-NAPHTHALENONE, 3,4-DIHYDRO-6-METHOXY-;6-Methoxy;6-METHOXY-3,4-DIHYDRO-2H-NAPHTHALEN-1-ONE;6-Methoxy-3,4-dihydro-1(2H)-naphthalenone;6-METHOXY-1,2,3,4-TETRAHYDRONAPHTHALEN-1-ONE;6-Methoxy-tetalone;6-Methoxy-1-tetraL;6-METHOXY TETRALONE
CBNumber: CB0277174
Molecular Formula: C11H12O2
Formula Weight: 176.21
MOL File: 1078-19-9.mol

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6-methoxy-1-tetralone Property

Melting point:: 77-79 °C (lit.)
Boiling point:: 171 °C/11 mmHg (lit.)
Density: 1.0558 (rough estimate)
refractive index: 1.5250 (estimate)
Flash point:: 171°C/11mm
storage temp.: Sealed in dry,Room Temperature
form: Fine Crystalline Powder
color: Yellow to light brown
PH: 5.96 at 23℃ and 10g/L
Merck: 14,6000
BRN: 972739
InChIKey: MNALUTYMBUBKNX-UHFFFAOYSA-N
CAS DataBase Reference: 1078-19-9(CAS DataBase Reference)
NIST Chemistry Reference: 1(2H)-Naphthalenone, 3,4-dihydro-6-methoxy-(1078-19-9)
EPA Substance Registry System: 1(2H)-Naphthalenone, 3,4-dihydro-6-methoxy- (1078-19-9)

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Safety

Hazard Codes: Xn,Xi
Risk Statements: 22-36/37/38-20/21/22
Safety Statements: 24/25-36-26
WGK Germany: 3
Hazard Note: Irritant
TSCA: Yes
HS Code: 29145000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P284Wear respiratory protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P342+P311IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: M25589
Product name: 6-Methoxy-1-tetralone
Purity: 99%
Packaging: 25g
Price: $36.66
Updated: 2024/03/01

Sigma-Aldrich

Product number: M25589
Product name: 6-Methoxy-1-tetralone
Purity: 99%
Packaging: 100g
Price: $99.5
Updated: 2024/03/01

TCI Chemical

Product number: M0787
Product name: 6-Methoxy-1-tetralone
Purity: >99.0%(GC)
Packaging: 25g
Price: $55
Updated: 2024/03/01

TCI Chemical

Product number: M0787
Product name: 6-Methoxy-1-tetralone
Purity: >99.0%(GC)
Packaging: 250g
Price: $318
Updated: 2024/03/01

Alfa Aesar

Product number: A15967
Product name: 6-Methoxy-1-tetralone, 99%
Packaging: 5g
Price: $18.65
Updated: 2024/03/01

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6-methoxy-1-tetralone Chemical Properties,Usage,Production

Chemical Properties

yellow to light brown fine crystalline powder

Uses

6-Methoxy-1-tetralone is a reagent useful in the synthesis of (2-(furanyl)vinyl)-1-tetralone chalcones which possesses anticancer agents and inducers of apoptosis.

Definition

ChEBI: 6-Methoxy-1-tetralone is a member of tetralins.

Preparation

(1) Reacting anisole with an acylating agent in Lewis acid and a solvent at the temperature of-10-40 ℃ to generate an intermediate 1, wherein the molar ratio of the Lewis acid to the acylating agent to the anisole is 1-10: 1-10: 1, the Lewis acid is selected from one or more of concentrated sulfuric acid, phosphoric acid, polyphosphoric acid, zinc chloride, aluminum trichloride, superacid and heteropoly acid;
(2) the intermediate 1 does not need to be separated, the temperature is raised to 70-120 ℃, and the intermediate 1 continues to react to generate 6-methoxy-1-tetralone;
(3) cooling the reaction product, adding water to stop the reaction, extracting, purifying and desolventizing to obtain a crude product of the 6-methoxy-1-tetralone, and refining the crude product by a solvent to obtain a high-purity product.

Synthesis Reference(s)

Journal of the American Chemical Society, 64, p. 94, 1942 DOI: 10.1021/ja01253a025
Tetrahedron Letters, 9, p. 2917, 1968 DOI: 10.1016/S0040-4039(00)89611-2

Synthesis

The synthesis of 6-methoxy-1-tetralone is as follows:Eaton's reagent (1.00 mL, 5.31 mmol) was added slowly to a stirred solution of methyl 4-(3-methoxyphenyl)butanoate (4; 0.37g, 1.78 mmol) in DCE (1 mL). The resulting mixture was stirred at 75 °C for 2h under N₂ atmosphere. Then, the reaction mixture was allowed to reach room temperature, and was poured over ice-water and extracted with EtOAc (3 × 15 mL). The combined organic extracts were washed successively with brine (2 × 15 mL) and H₂O (2 × 20 mL), filtered over Na₂SO₄ and concentrated under reduced pressure. The resulting brownish oil was fractionated by column chromatography (silica gel, EtOAc-hexanes, 1:9) to obtain 6-methoxy-1-tetralone as ayellowish oil; yield: 0.28 g (91%).

6-methoxy-1-tetralone Preparation Products And Raw materials

Raw materials

FUMING SULFURIC ACID 6-METHOXY-1,2,3,4-TETRAHYDRONAPHTHALENE Detergent

Preparation Products

17-Ethinyl-3,17-dihydroxy-18-methylestra-2,5(10)-diene3-methylether 3-Methoxy-18-methylestra-1,3,5(10),8-tetraen-17-ethylene ketal 17-Ethinyl-17-hydroxy-18-methylestra-5(10),9(11)-dien-3-one-3-ethylene ketal 3-Methoxy-18-methylestra-2,5(10)dien-17-one 17-ethylene ketal

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6-methoxy-1-tetralone Suppliers

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View Lastest Price from 6-methoxy-1-tetralone manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: 6-methoxy-1-tetralone 1078-19-9
Price: US $0.00/KG
Min. Order: 1KG
Purity: 98%min
Supply Ability: 30tons/month
Release date: 2023-02-22

HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD

Product: 6-methoxy-1-tetralone 1078-19-9
Price: US $100.00-75.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 5000
Release date: 2024-08-22

Hebei Chuanghai Biotechnology Co,.LTD

Product: 6-methoxy-1-tetralone 1078-19-9
Price: US $30.00-10.00/kg
Min. Order: 10kg
Purity: 99%
Supply Ability: 100000kg
Release date: 2024-08-20

1078-19-9, 6-methoxy-1-tetraloneRelated Search:

Nabumetone 1-Tetralone (Trifluoromethoxy)benzene 2-Bromo-6-methoxynaphthalene 6-Methoxy-2-naphthaldehyde 7-Methoxy-1-tetralone 6,7-Dimethoxy-1-tetralone 7-Methoxy-2-tetralone 6,7-Dimethoxy-2-tetralone 5-Methoxy-3,4-dihydro-2H-naphthalen-1-one 5 8-DIMETHOXY-1-TETRALONE 99 5-Methoxy-2-tetralone 1,2,3,4-Tetrahydronaphthalene 6-METHOXY-1,2,3,4-TETRAHYDRONAPHTHALENE 6-METHOXY-2-METHYL-1-TETRALONE 6,7-(METHYLENEDIOXY)-1-TETRALONE dactylocycline B 3,11-DIMETHOXY-7-PHENYL-6,8,9,13B-TETRAHYDRO-5H-DIBENZO[C,H]XANTHYLIUM PERCHLORATE

6-METHOXY-1,2,3,4-TETRAHYDRONAPHTHALEN-1-ONE

6-METHOXY-1,2,3,4-TETRAHYDRO-1-NAPHTHALENONE

6-METHOXY-1,2,3,4-TETRAHYDRO-1-NAPHTHONE

6-METHOXY-3,4-DIHYDRO-2H-NAPHTHALEN-1-ONE

6-METHOXY-1-TETRALONE

6-METHOXY TETRALONE

6-METHOXY-ALPHA-TETRALONE

TIMTEC-BB SBB007549

6-Methoxy-1,2,3,4-tetrahydro-1-naphthalenone for synthesis

3,4-dihydro-6-methoxy-1(2h)-naphthalenon

3,4-Dihydro-6-methoxy-1(2H)-napthalenone

6-Methoxy-3,4-dihydro-1(2H)-naphthalenone

6-Methoxy-tetalone

6-Methoxytetralin-1-one

3,4-Dihydro-6-methoxynaphthalen-1(2H)-one 98%

6-Methoxy-1-tetralone, 99% 25GR

6-METHOXY-1,2,3,4-TETRAHYDRO-1-NAPHTHALE

METHOXY(6-)-1-TETRALONE

3,4-DIHYDRO-6-METHOXY-1(2H)-NAPHTHALENONE

1(2H)-NAPHTHALENONE, 3,4-DIHYDRO-6-METHOXY-

6-Metoxy-1-tetralone

6-Methoxy-1-Tetralon

6-METHOXYA-TETRALONE

6-Methoxy

6-Methoxy-l-tetralone

1,2,3,4-Tetrahydro-6-methoxy-1-naphthalenone

1-Oxo-1,2,3,4-tetrahydro-6-methoxynaphthalene

6-Methoxy-1-oxo-1,2,3,4-tetrahydronaphthalene

3,4-Dihydro-6-methoxynaphthalen-1(2H)-one

6-Methoxy-3,4-dihydronaphthalen-1(2H)-one

6-Methoxy-1-tetraL

Levonorgestrel Impurity 13

Levonorgestrel Impurity 13 (6-Methoxy-1-tetralone)

6-Methoxy-1-tetralone&gt

1078-19-9

1078-19-1

KETONE

Building Blocks

C11 to C12

Carbonyl Compounds

Organic Building Blocks

Ketones

Ketone

C11 to C12

Carbonyl Compounds

Ketones

Carbonyl Compounds