6-Bromo-1H-indol-4-amine
- Product Name
- 6-Bromo-1H-indol-4-amine
- CAS No.
- 350800-81-6
- Chemical Name
- 6-Bromo-1H-indol-4-amine
- Synonyms
- 4-AMINO-6-BROMOINDOLE;6-BROMO-4-AMINOINDOLE;6-BROMOINDOL-4-YLAMINE;6-bromo-1H-indol-4-amine;4-Amino-6-bromo-1H-indole;1H-Indol-4-aMine, 6-broMo-
- CBNumber
- CB0277482
- Molecular Formula
- C8H7BrN2
- Formula Weight
- 211.06
- MOL File
- 350800-81-6.mol
6-Bromo-1H-indol-4-amine Property
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- Appearance
- White to off-white Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- A607818
- Product name
- 4-Amino-6-bromoindole
- Packaging
- 10mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- HCH0012844
- Product name
- 4-AMINO-6-BROMOINDOLE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $1431.05
- Updated
- 2021/12/16
- Product number
- 350800816
- Product name
- 6-Bromo-1H-indol-4-amine
- Packaging
- 5g
- Price
- $1735.22
- Updated
- 2021/12/16
- Product number
- A127841
- Product name
- 6-Bromo-1H-indol-4-amine
- Purity
- 95%
- Packaging
- 100mg
- Price
- $70
- Updated
- 2021/12/16
- Product number
- A127841
- Product name
- 6-Bromo-1H-indol-4-amine
- Purity
- 95%
- Packaging
- 250mg
- Price
- $104
- Updated
- 2021/12/16
6-Bromo-1H-indol-4-amine Chemical Properties,Usage,Production
Synthesis
350800-78-1
350800-81-6
To 6-bromo-1H-indol-4-amine (3 g, 9.49 mmol) was added HCl solution (61.20 g, 167.86 mmol) of TiCl3 (7.32 g, 47.45 mmol). The reaction mixture was stirred at 25 °C for 16 hours. After completion of the reaction, the mixture was slowly poured into 2N aqueous NaOH solution (150 mL) and extracted with EtOAc (150 mL). The organic phase was dried over anhydrous Na2SO4, filtered and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography (eluent: petroleum ether to petroleum ether/ethyl acetate = 5/1) to afford 6-bromo-1H-indol-4-amine (2 g, 36% yield) as a gray solid.1H NMR (CDCl3, 400 MHz) δ 8.10 (br s, 1H), 7.09-7.08 (m, 1H), 7.02 (d, J = 1.4Hz , 1H), 6.54 (d, J = 1.4Hz, 1H), 6.44-6.43 (m, 1H), 3.98 (br s, 2H).
References
[1] Patent: WO2016/168682, 2016, A2. Location in patent: Paragraph 0256
[2] European Journal of Medicinal Chemistry, 2001, vol. 36, # 2, p. 165 - 178
6-Bromo-1H-indol-4-amine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 6-Bromo-1H-indol-4-amine manufacturers
- Product
- 4-AMINO-6-BROMOINDOLE 350800-81-6
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 200kg
- Release date
- 2020-01-09