ChemicalBook > CAS DataBase List > 6-BROMO-4-FLUORO INDOLE

6-BROMO-4-FLUORO INDOLE

Product Name
6-BROMO-4-FLUORO INDOLE
CAS No.
885520-59-2
Chemical Name
6-BROMO-4-FLUORO INDOLE
Synonyms
6-BROMO-4-FLUORO INDOLE;4-Fluoro-6-bromo-indole;6-broMo-4-fluoro-1H-indole;1H-Indole, 6-broMo-4-fluoro-
CBNumber
CB2111896
Molecular Formula
C8H5BrFN
Formula Weight
214.03
MOL File
Mol file
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6-BROMO-4-FLUORO INDOLE Property

Boiling point:
315.1±22.0 °C(Predicted)
Density 
1.750±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
pka
15.47±0.30(Predicted)
Appearance
Off-white to light brown Solid
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Safety

HS Code 
2933998090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
B804275
Product name
6-Bromo-4-fluoro-1H-indole
Packaging
1mg
Price
$45
Updated
2021/12/16
TRC
Product number
B804275
Product name
6-Bromo-4-fluoro-1H-indole
Packaging
2mg
Price
$60
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB105513
Product name
6-Bromo-4-fluoro-1H-indole
Packaging
100mg
Price
$150
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB105513
Product name
6-Bromo-4-fluoro-1H-indole
Packaging
250mg
Price
$250
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB105513
Product name
6-Bromo-4-fluoro-1H-indole
Packaging
500mg
Price
$350
Updated
2021/12/16
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6-BROMO-4-FLUORO INDOLE Chemical Properties,Usage,Production

Synthesis

18503-89-4

502496-34-6

885520-59-2

To a dry 100 mL round bottom flask was added 4-bromo-2-fluoro-6-nitrotoluene (1.3 g, 5.56 mmol, 1 eq.), N,N-dimethylformamide diisopropyl acetal (2.6 mL, 12.22 mmol, 2.2 eq.), triethylamine (0.85 mL, 6.11 mmol, 1.1 eq.) and anhydrous DMF (5 mL). The mixture was stirred at 130 °C for 2 hours. Upon completion of the reaction, the solvent was removed under reduced pressure and the residue was dissolved in a solvent mixture of toluene (30 mL) and acetic acid (40 mL). Iron powder (6.2 g, 11.10 mmol, 20 eq.) and silica (6 g) were then added. The dark red mixture was heated to 100 °C under vigorous stirring and maintained for 30 min. After the reaction mixture was cooled to room temperature, it was diluted with EtOAc, filtered and the solid was washed thoroughly with EtOAc. The combined filtrates were washed sequentially with saturated aqueous NaHCO3, aqueous Na2S2O3, saturated aqueous NaHCO3 and brine, dried over Na2SO4 and concentrated under reduced pressure. Purification of the residue by fast column chromatography (20% DCM in hexane solution) afforded 6-bromo-4-fluoro-1H-indole (814 mg, 3.75 mmol, 68% yield; UPLC purity: 99%).

References

[1] Patent: WO2016/180537, 2016, A1. Location in patent: Page/Page column 181; 182

6-BROMO-4-FLUORO INDOLE Preparation Products And Raw materials

Raw materials

Preparation Products

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6-BROMO-4-FLUORO INDOLE Suppliers

China 81 India 2 United Kingdom 4 United States 6 Global 93
Accela ChemBio Co.,Ltd.
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021-50795510 4000665055
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021-50795055
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sales@accelachem.com
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China
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Shanghai Devinchem Ltd
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027-65318838 13646286950
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sales@devinchem.com
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Shanghai Run-Biotech Co., Ltd.
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021-57171705 13817537615
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+86-510-68873513
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Bide Pharmatech Ltd.
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Shenzhen Gre-syn Chemical Technology Co., Ltd.
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Bellen Chemistry Co., Ltd.
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010-60400365-8001 15910885229
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010-60400361
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service@bellenchem.com
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Tianjin Being Technology Co., Ltd.
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18622939839
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QQ:343281693
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tjby921@163.com
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View Lastest Price from 6-BROMO-4-FLUORO INDOLE manufacturers

SHANGHAI FLUORORING PHARMACEUTICAL CO LTD
Product
4-Fluoro-6-bromo-indole 885520-59-2
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
99
Supply Ability
100
Release date
2025-07-02
Career Henan Chemical Co
Product
6-BROMO-4-FLUORO INDOLE 885520-59-2
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
200kg
Release date
2019-12-31

885520-59-2, 6-BROMO-4-FLUORO INDOLERelated Search:

1H-Indole, 4-broMo-6-(trifluoroMethyl)- 1H-Indole, 6-broMo-4-(phenylMethoxy)- 4-BROMO-6-AMINOINDOLE 1H-Indole, 6-broMo-4-nitro- 6-Chloro-4-methoxyindole 1H-Indol-4-amine,6-iodo-(9CI) 6-Bromo-1H-indol-4-amine

  • 6-BROMO-4-FLUORO INDOLE
  • 1H-Indole, 6-broMo-4-fluoro-
  • 6-broMo-4-fluoro-1H-indole
  • 4-Fluoro-6-bromo-indole
  • 885520-59-2