1H-Indole, 4-broMo-6-(trifluoroMethyl)-

Product Name: 1H-Indole, 4-broMo-6-(trifluoroMethyl)-
CAS No.: 1000342-93-7
Chemical Name: 1H-Indole, 4-broMo-6-(trifluoroMethyl)-
Synonyms: 4-broMo-6-trifluoroMethyl-1H indole;4-bromo-6-(trifluoromethyl)-2H-indole;1H-Indole, 4-broMo-6-(trifluoroMethyl)-
CBNumber: CB92606483
Molecular Formula: C9H5BrF3N
Formula Weight: 264.04
MOL File: 1000342-93-7.mol

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1H-Indole, 4-broMo-6-(trifluoroMethyl)- Property

Boiling point:: 298.1±35.0 °C(Predicted)
Density: 1.742±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
pka: 14.66±0.30(Predicted)
Appearance: Colorless to light yellow Liquid
InChI: InChI=1S/C9H5BrF3N/c10-7-3-5(9(11,12)13)4-8-6(7)1-2-14-8/h1-4,14H
InChIKey: GVQHXKQOACYLJU-UHFFFAOYSA-N
SMILES: N1C2=C(C(Br)=CC(C(F)(F)F)=C2)C=C1

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H317May cause an allergic skin reaction

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TRC

Product number: B811243
Product name: 4-Bromo-6-(trifluoromethyl)-1H-indole
Packaging: 50mg
Price: $175
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0621226
Product name: 4-BROMO-6-(TRIFLUOROMETHYL)-1H-INDOLE
Purity: 95.00%
Packaging: 5MG
Price: $454.35
Updated: 2021/12/16

AK Scientific

Product number: 0051AA
Product name: 4-Bromo-6-(trifluoromethyl)-1H-indole
Packaging: 5g
Price: $897
Updated: 2021/12/16

Ambeed

Product number: A101212
Product name: 4-Bromo-6-(trifluoromethyl)-1H-indole
Purity: 98+%
Packaging: 100mg
Price: $30
Updated: 2021/12/16

Abosyn

Product number: 21-2718
Product name: 4-bromo-6-(trifluoromethyl)-1H-indole
Purity: 95%-98%
Packaging: 1g
Price: $585
Updated: 2021/12/16

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1H-Indole, 4-broMo-6-(trifluoroMethyl)- Chemical Properties,Usage,Production

Uses

1H-Indole, 4-bromo-6-(trifluoromethyl)- can be used as a research compound for its unique reactivity due to the presence of both the halogen and the highly electronegative trifluoromethyl group.

Synthesis

1100215-58-4

1000342-93-7

A solution of 3-bromo-2-ethynyl-5-(trifluoromethyl)aniline (7.54 g, 28.6 mmol) was slowly added dropwise from its N-methylpyrrolidone (50 mL) solution to an N-methylpyrrolidone (200 mL) solution of potassium tert-butoxide (6.41 g, 57.1 mmol) at 0°C. The reaction mixture was stirred at room temperature for 4 hours. Subsequently, the reaction mixture was poured into brine (500 mL) and extracted with ethyl acetate (4 x 50 mL). The organic layers were combined, washed with brine (100 mL), dried over magnesium sulfate and concentrated. The residue was purified by silica gel column chromatography using a 10% to 25% ethyl acetate/hexane gradient elution to afford 4-bromo-6-trifluoromethyl-1H-indole (7.16 g, 95% yield) as a brown oil. The product was confirmed by 1H-NMR (CDCl3, 400 MHz) and LC/MS (HPLC Method 4): 1H-NMR δ 8.54 (bs, 1H), 7.63 (s, 1H), 7.53 (s, 1H), 7.40 (t, J = 2.8Hz, 1H), 6.66 (t, J = 2.8Hz, 1H); LC/MS: tR = 3.280min, 264.12 (MH)+.

References

[1] Patent: US2009/18132, 2009, A1. Location in patent: Page/Page column 85; 86
[2] Patent: US2015/266872, 2015, A1. Location in patent: Paragraph 0668; 0669
[3] Patent: EP2982670, 2016, A1

1H-Indole, 4-broMo-6-(trifluoroMethyl)- Preparation Products And Raw materials

Raw materials

Preparation Products

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1H-Indole, 4-broMo-6-(trifluoroMethyl)- Suppliers

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View Lastest Price from 1H-Indole, 4-broMo-6-(trifluoroMethyl)- manufacturers

Career Henan Chemical Co

Product: 1H-Indole, 4-broMo-6-(trifluoroMethyl)- 1000342-93-7
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1lg; 2kg; 5kg; 10kg; 100kg
Release date: 2019-08-31

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