BOC-D-4,4'-BIPHENYLALANINE

Product Name: BOC-D-4,4'-BIPHENYLALANINE
CAS No.: 128779-47-5
Chemical Name: BOC-D-4,4'-BIPHENYLALANINE
Synonyms: BOC-D-4;impurity 43;BOC-D-BPH-OH;BOC-D-BIP-OH;-BIPHENYLALANINE;BOC-D-BIP(4,4')-OH;SACUBITRIL(LCZ696);BOC-D-4,4'-BIPHE-OH;LCZ-696 Impurity 80;BOC-4-BIPHENYL-D-ALA
CBNumber: CB0285209
Molecular Formula: C20H23NO4
Formula Weight: 341.4
MOL File: 128779-47-5.mol

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BOC-D-4,4'-BIPHENYLALANINE Property

Boiling point:: 528.2±50.0 °C(Predicted)
Density: 1.161±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Store in freezer, under -20°C
solubility: DMSO (Slightly), Methanol (Slightly)
form: Solid
pka: 3.88±0.10(Predicted)
Appearance: White to off-white Solid
CAS DataBase Reference: 128779-47-5(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
HS Code: 2922498590

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

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N-Bromosuccinimide Price

TRC

Product number: B642900
Product name: Boc-D-4,4''-biphenylalanine
Packaging: 1g
Price: $95
Updated: 2021/12/16

Activate Scientific

Product number: AS32716
Product name: Boc-D-4,4-Biphenylalanine
Purity: 95+% ee
Packaging: 1g
Price: $29
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB47981
Product name: Boc-p-phenyl-D-Phenylalanine
Packaging: 1g
Price: $40
Updated: 2021/12/16

Chem-Impex

Product number: 04083
Product name: Boc-p-phenyl-D-phenylalanine,99%(HPLC)
Purity: 99%(HPLC)
Packaging: 1G
Price: $40.54
Updated: 2021/12/16

Matrix Scientific

Product number: 074852
Product name: Boc-D-4,4-Biphenylalanine
Purity: 95+%
Packaging: 1g
Price: $44
Updated: 2021/12/16

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BOC-D-4,4'-BIPHENYLALANINE Chemical Properties,Usage,Production

Uses

Boc-D-4,4'-biphenylalanine is used as a reagent in the synthesis of pyrrolopyrimidine inhibitors of Akt as antitumor agents. Boc-D-4,4'-biphenylalanine is also used in the preparation of (-)-Bestatin-based inhibitors.

Synthesis

24424-99-5

155760-02-4

119273-61-9

To a mixed solution of tetrahydrofuran (THF) (80 mL) and water (80 mL) of (S)-3-([1,1'-biphenyl]-4-yl)-2-aminopropanoic acid (25) (5 g, 20.72 mmol) was added di-tert-butyl dicarbonate (BOC2O) (5.77 mL, 24.87 mmol) and sodium hydroxide (NaOH) (1.077 g. 26.9 mmol). The reaction mixture was stirred at room temperature for 6 hours before being cooled to 0 °C and the pH was adjusted to about 6-7 by slowly adding 1.5 N aqueous hydrochloric acid (HCl) to quench the reaction. Subsequently, the reaction mixture was extracted with ethyl acetate (EtOAc) (3 x 50 mL). The combined organic layers were washed sequentially with brine (50 mL) and water (50 mL), dried over anhydrous sodium sulfate and concentrated to give the crude product as a colloidal off-white solid. The crude product was purified by washing with petroleum ether (PE) with 10% ethyl acetate (4 x 20 mL). The resulting white solid was filtered and dried under vacuum to afford (S)-3-([1,1'-biphenyl]-4-yl)-2-((tert-butoxycarbonyl)amino)propionic acid (26) (6.5 g, 19.04 mmol, 92% yield). The product was analyzed by 1H NMR (400 MHz, DMSO-d6) and mass spectrometry (ESI) to confirm the structure.1H NMR data: δ 7.67-7.62 (m, 2H), 7.58 (d, J=8.5 Hz, 2H), 7.50-7.43 (m, 2H), 7.39-7.31 (m, 3H), 7.10 (d, J=8.0 Hz. 1H), 4.17-4.07 (m, 1H), 3.07 (dd, J=13.6,4.5Hz, 1H), 2.88 (dd, J=13.6,10.0Hz, 1H), 1.37-1.23 (m, 9H). Mass spectral data: 340.2 ([M-1]-).

References

[1] Tetrahedron Letters, 2018, p. 4267 - 4271

BOC-D-4,4'-BIPHENYLALANINE Preparation Products And Raw materials

Raw materials

Preparation Products

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BOC-D-4,4'-BIPHENYLALANINE Suppliers

China 120 France 1 Germany 3 India 2 Japan 2 South Korea 1 United Kingdom 5 United States 23 Global 157

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View Lastest Price from BOC-D-4,4'-BIPHENYLALANINE manufacturers

Zhuozhou Wenxi import and Export Co., Ltd

Product: BOC-D-4,4"-BIPHENYLALANINE 128779-47-5
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-08-11

Career Henan Chemical Co

Product: BOC-D-4,4'-BIPHENYLALANINE 128779-47-5
Price: US $7.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2018-12-24

Career Henan Chemical Co

Product: BOC-D-4,4'-BIPHENYLALANINE 128779-47-5
Price: US $7.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100kg
Release date: 2018-12-24

128779-47-5, BOC-D-4,4'-BIPHENYLALANINERelated Search:

Telmisartan Impurity 10 1426129-50-1 enantioMer (R,E)-ethyl 5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpent-2-enoate N-[2’-(1H-tetrazol-5-yl)biphenyl-4-yl methyl]-N-Valeryl-(L)-Valine benzyl ester N-NITROSO-DI-ISO-PROPYLAMINE LCZ-696 Impurity 60 Valsartan Impurity 32 (2R,4S)-ethyl 5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpentanoate Valsartan Impurity 1 [1,1'-Biphenyl]-4-pentanoic acid, γ-amino-α-methyl-, ethyl ester, (Hydrochloride)(1:1), (αS,γS)- 4-(2-Cyanophenyl)benzyl alcohol Valsartan n-Propyl Valsartan Desvaleryl Impurity Isoleucine Valsartan USAWIVMZUYOXCF-UHFFFAOYSA-N Valsartan Ethyl Ester Valsartan Impurity 3 Valsartan Impurity 61

BOC-D-PHE(4-PHENYL)-OH

BOC-D-BPH-OH

BOC-D-BIP(4,4')-OH

BOC-D-BIP-OH

BOC-D-ALA(4,4'-BIPHENYL)-OH

BOC-3-(4-BIPHENYLYL)-D-ALANINE

BOC-4-PHENYL-D-PHENYLALANINE

BOC-4-PHENYL-D-PHE-OH

BOC-4-BIPHENYL-D-ALA

BOC-BETA-(4-BIPHENYLYL)-D-ALA-OH

BOC-P-PHENYL-D-PHE-OH

BOC-(R)-2-AMINO-3-(1,1'-BIPHENY-4-YL)PROPANOIC ACID

D-TBOC-P-BIPHENYLALANINE

(R)-3-BIPHENYL-4-YL-2-TERT-BUTOXYCARBONYLAMINO-PROPIONIC ACID

Boc-D-4-Phenylphenylalanine

N-ALPHA-T-BUTOXYCARBONYL-D-4,4'-BIPHENYLALANINE

N-ALPHA-T-BUTOXYCARBONYL-D-(4-PHENYL)PHENYLALANINE

(R)-N-ALPHA-TERT-BUTYLOXYCARBONYL-BIPHENYLALANINE

N-Boc-3-(4-biphenylyl)-D-alanine, 95%

(2R)-3-(Biphenyl-4-yl)-2-[(tert-butoxycarbonyl)amino]propanoic acid

(2R)-3-(Biphenyl-4-yl)-2-[(tert-butoxycarbonyl)amino]propionic acid, tert-Butyl [(1R)-2-(biphenyl-4-yl)-1-carboxyethyl]carbamate

(R)-a-(Boc-amino)-biphenyl-4-propanoic acid

N-Boc-3-(4-biphenylyl)-D-alani

(2R)-2-[(2-methylpropan-2-yl)oxycarbonylamino]-3-(4-phenylphenyl)propanoic acid

Boc-p-phenyl-D-Phenylalanine≥ 99% (HPLC)

4-Phenyl-D-phenylalanine, N-BOC protected

(R)-3-(biphenyl-4-yl)-2-(tert-butoxycarbonylamino)propanoic acid

(R)-N-ALPHA-T-BUTYLOXYCARBONYL-BIPHENYLALANINE

3-(4-Biphenylyl)-N-(tert-butoxycarbonyl)-D-alanine

REF DUPL: Boc-D-4,4'-Biphenylalanine

(S)-2-AMino-3-(4'-((S)-2-(tert-butoxycarbonylaMino)-2-carboxyethyl)biphenyl-4-yl)propanoic acid

Boc-b-(4-biphenylyl)-D-Ala-OH, Boc-D-Bip-OH

BOC-D-4,4'-BIPHE-OH

[1,1'-Biphenyl]-4-propanoic acid, α-[[(1,1-dimethylethoxy)carbonyl]amino]-, (αR)-

(Tert-Butoxy)Carbonyl D-4,4'-Biphenylalanine

(R)-3-([1,1\'-biphenyl]-4-yl)-2-aminopropanoic acid hydrochloride

Sacubitril Impurity 55

SACUBITRIL(LCZ696)

-BIPHENYLALANINE

(2R)-3-{[1,1'-biphenyl]-4-yl}-2-{[(tert-butoxy)carbonyl]amino}propanoic acid

impurity 43

N-Boc-3-(4-biphenylyl)-D-alanine,95%

(2R)-2-[(2-methylpropan-2-yl)oxycarbonylamino]-3-(4-phenylphenyl)propanoicaci

BOC-D-4,4'-BIPHENYLALANINE USP/EP/BP

BOC-D-4

LCZ-696 Impurity 80

Boc-d-4,4'-biphenylalanine

(R)-3-([1,1'-Biphenyl]-4-yl)-2-((tert-butoxycarbonyl)amino)propanoic acid

LCZ696 valsartan + sacubitril impurity 43

N-Boc-3-(4-biphenylyl)-D-alanine

128779-47-5

C20H23NO4

Phenylalanine analogs and other aromatic alpha amino acids

Amino Acids

a-amino

Biphenyl & Diphenyl ether

Amino Acid Derivatives