Oxethazaine

Product Name: Oxethazaine
CAS No.: 126-27-2
Chemical Name: Oxethazaine
Synonyms: fh099;C12552;mutesa;oxaine;Wy 806;tepilta;mucaine;mucoxin;muthesa;betalgil
CBNumber: CB0287425
Molecular Formula: C28H41N3O3
Formula Weight: 467.64
MOL File: 126-27-2.mol

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Oxethazaine Property

Melting point:: 104-105°C
Boiling point:: 570.1°C (rough estimate)
Density: 1.0974 (rough estimate)
refractive index: 1.7800 (estimate)
storage temp.: Refrigerator
solubility: Practically insoluble in water; freely soluble in methanol; soluble in ethyl acetate.
pka: 14.62±0.10(Predicted)
form: Solid
color: White to Off-White
Water Solubility: <0.1 g/100 mL at 23 ºC
CAS DataBase Reference: 126-27-2(CAS DataBase Reference)
EPA Substance Registry System: Oxethazaine (126-27-2)

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Safety

Hazard Codes: Xn
Risk Statements: 22
Safety Statements: 36
WGK Germany: 3
RTECS: AC3325000
Toxicity: LD50 oral in rat: 1gm/kg

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: O5380
Product name: Oxethazaine
Purity: analytical standard
Packaging: 5g
Price: $160
Updated: 2024/03/01

AK Scientific

Product number: 2622AH
Product name: Oxethazaine
Packaging: 10mg
Price: $115
Updated: 2021/12/16

ApexBio Technology

Product number: A8494
Product name: Oxethazaine
Packaging: 5g
Price: $150
Updated: 2021/12/16

ApexBio Technology

Product number: A8494
Product name: Oxethazaine
Packaging: 10mM(in 1mL DMSO)
Price: $50
Updated: 2021/12/16

ApexBio Technology

Product number: A8494
Product name: Oxethazaine
Packaging: 1g
Price: $50
Updated: 2021/12/16

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Oxethazaine Chemical Properties,Usage,Production

Chemical Properties

White Solid

Originator

Oxaine,Wyeth,US,1960

Uses

A potent local anesthetic that is active even in acidic conditions. It is used (usually in combination with an antacid) for the relief of pain associated with peptic ulcer disease or esophagitis.

Uses

antiviral, RT inhibitor

Definition

ChEBI: Oxethazaine is an amino acid amide.

Manufacturing Process

Chlor-N-methyl-N-ω-phenyl-tert-butyl acetamide (23.95 g) (0.1 mol) is added to n-butanol (150.0 cc) containing anhydrous potassium carbonate (50.0 g). To the stirred refluxing solution is added dropwise freshly distilled ethanolamine (3.1 g) (0.05 mol). Stirring and refluxing is maintained for twenty hours. Upon cooling the solution is filtered; the residue is washed with n-butanol. The combined filtrates are washed with aqueous sodium carbonate solution then water and finally dried over anhydrous magnesium sulfate. The solvent is distilled under vacuum leaving a dry solid residue. The residue is dissolved in dry benzene to which is added n-hexane to crystallize the product melting at 104°C to 104.5°C. Yield 71-73%. Analysis-Carbon: calc. 71.9%; found 71.93%; hydrogen: calc. 8.8%; found 8.9%; nitrogen: calc. 9.0%; found 9.0%.
To make the hydrochloride salt, the bisacetamide or, by another name, 1,11diphenyl-2,2,3,9,10,10-hexamethyl-4,8-diketo-6-(β-hydroxyethyl)-3,6,9triazaundecane is dissolved in n-butanol. The solution is chilled and then dry hydrogen chloride gas is passed into the solution causing an oil to separate. To the heavy oil ether is added and then stirred causing crystallization to occur. MP 146°C to 147°C. Analysis for nitrogen: calc. 83%. found 8.2%.
To make the acetate salt, the bisacetamide (4.7 g) (0.01 mol) is dissolved in ethyl acetate to which is added glacial acetic acid (0.6 g) (0.01 mol). Ether is added to precipitate the acetate as a gum which is washed with hexane, and finally added to dry ether. Allow to stand for crystallization. MP 141°C. Analysis for nitrogen: calc. 8.0%; found 8.2%.
Other salts are: sulfate, MP 56°C; acid oxalate, MP 127°C; tartrate, MP 45°C; picrate, MP 151°C to 152°C.

Therapeutic Function

Local anesthetic

General Description

White powder.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

A hydroxylated amide. Organic amides/imides react with azo and diazo compounds to generate toxic gases. Flammable gases are formed by the reaction of organic amides/imides with strong reducing agents. Amides are very weak bases (weaker than water). Imides are less basic yet and in fact react with strong bases to form salts. That is, they can react as acids. Mixing amides with dehydrating agents such as P2O5 or SOCl2 generates the corresponding nitrile. The combustion of these compounds generates mixed oxides of nitrogen (NOx).

Fire Hazard

Flash point data are not available for Oxethazaine, but Oxethazaine is probably combustible.

Oxethazaine Preparation Products And Raw materials

Raw materials

Preparation Products

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Oxethazaine Suppliers

Canada 1 China 63 Germany 1 India 7 South Korea 1 Switzerland 1 United Kingdom 3 United States 18 Global 95

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View Lastest Price from Oxethazaine manufacturers

Zhuozhou Wenxi import and Export Co., Ltd

Product: Oxethazaine 126-27-2
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-08-11

126-27-2, OxethazaineRelated Search:

3,4'-DIAMINODIPHENYLMETHANE tert-Butyl acetate Monoethanolamine 2,2-Diethoxyethylamine 2-(4-Aminophenyl)ethanol Thiophanate-methyl Benzocaine tert-Butanol Articaine PHENYL VALERATE 2-AMINO-1-PHENYLETHANOL Tribenuron methyl Mepivacaine tert-Butyl peroxyacetate Mepivacaine hydrochloride Kresoxim-methyl Methyl salicylate Methyl

OXETHAZAINE

OXETHAZINE

OXETACAINE

2-hydroxyethyliminobis(n-[α,α-dimethylphenethyl]-n-methylacetamide)

2,2'-[(2-Hydroxyethyl)imino]bis[N-(a,a-dimethylphenethyl)-N-methylacetamide]

Acetamide, 2,2'-[(2-hydroxyethyl)imino]bis[N-(1,1-dimethyl-2-phenylethyl)-N-methyl-

C12552

2,2’-((2-hydroxyethyl)imino)bis(n-(1,1-dimethyl-2-phenylethyl)-n-methylaceta

2,2’-((2-hydroxyethyl)imino)bis(n-(alpha,alpha-dimethylphenethyl)-n-acetamid

2,2’-((2-hydroxyethyl)imino)bis(n-(alpha,alpha-dimethylphenethyl)-n-methylac

acetamide,2,2’-(2-hydroxyethyl)imino)bis(n-(1,1-dimethylphenylethyl)-n-methy

betalgil

fh099

oxethacaine

stomacain

tepilta

topicain

2-HYDROXYETHYLIMINOBIS-[N-(ALPHA,ALPHA-DIMETHYLPHENETHYL)-N-METHYLACETAMIDE]

2-di(n-methyl-n-phenyl-tert-butyl-carbamoylmethyl)aminoethanol

N,N-bis(alpha,alpha-dimethylphenethyl)-N,N-dimethyl-2,2-(2-hydroxyethylimino)di(acetamide)

mucaine

mucoxin

mutesa

muthesa

n,n-bis(n-methyl-n-phenyl-tert-butylacetamido)-beta-hydroxyethylamine

oxaine

oxethacaina

2,2'-[(2-Hydroxyethyl)iMino]bis[N-(α,α-diMethylphenethyl)-N-MethylacetaMide]

Storocain

Storocaine

Wy 806

Oxethazaine API - BP

OxetacaineQ: What is Oxetacaine Q: What is the CAS Number of Oxetacaine Q: What is the storage condition of Oxetacaine Q: What are the applications of Oxetacaine

peptic ulcer disease,hemorrhoid,Inhibitor,esophagitis,HBV,analgesic,Oxethazaine,inhibit,precursor,Hepatitis B virus

Clopamide Impurity 2 (Clopamide EP Impurity B)

126-27-2

C28H41N3O3

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