Toremifene
- Product Name
- Toremifene
- CAS No.
- 89778-26-7
- Chemical Name
- Toremifene
- Synonyms
- Toremifene USP/EP/BP;(2-[4-((Z)-4-CHLORO-1,2-DIPHENYL-BUT-1-ENYL)-PHENOXY]-ETHYL)-DIMETHYL-AMINE;C08166;101083;TOREMIFENE;Z-ToreMifene;Toremifene-d6;ChlortaMoxifen;2-diphenyl-1-butenyl)phenoxy)-n,n-dimethyl-2-(4-(4-chloro-(z)-ethanamin;2-[4-(4-chloro-1,2-diphenyl-but-1-enyl)phenoxy]-n,n-dimethyl-ethanamine
- CBNumber
- CB0287854
- Molecular Formula
- C26H28ClNO
- Formula Weight
- 405.96
- MOL File
- 89778-26-7.mol
Toremifene Property
- Melting point:
- 108-110°C
- Boiling point:
- 535.1±50.0 °C(Predicted)
- Density
- 1.104±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- 25℃: DMSO 120mg/mL ;Water <1mg/mL; Ethanol <1mg/mL
- pka
- 8.69±0.28(Predicted)
- form
- Powder
- color
- White to light yellow
- Stability:
- Light sensitive
- CAS DataBase Reference
- 89778-26-7(CAS DataBase Reference)
- IARC
- 3 (Vol. 66) 1996
Safety
- HazardClass
- 9
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H318Causes serious eye damage
H400Very toxic to aquatic life
H410Very toxic to aquatic life with long lasting effects
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- J63803
- Product name
- Toremifene, 98+%
- Packaging
- 1g
- Price
- $193
- Updated
- 2023/06/20
- Product number
- J63803
- Product name
- Toremifene, 98+%
- Packaging
- 5g
- Price
- $632
- Updated
- 2021/12/16
- Product number
- 30728
- Product name
- Toremifene-d6
- Packaging
- 1mg
- Price
- $396
- Updated
- 2024/03/01
- Product number
- J63803
- Product name
- Toremifene, 98+%
- Packaging
- 500mg
- Price
- $121
- Updated
- 2023/06/20
- Product number
- T547513
- Product name
- Toremifene
- Packaging
- 100mg
- Price
- $180
- Updated
- 2021/12/16
Toremifene Chemical Properties,Usage,Production
Description
Toremifene is an antiestrogenic anticancer agent effective in the treatment of advanced recurrent breast cancer in postmenopausal patients. It is claimed to be more effective than tamoxifen in several rat mammary tumor models. Side-effects are mild, including hot flushes and sweating.
Chemical Properties
White-to-Off-White Solid
Originator
Farmos (Finland)
Uses
antineoplastic;selective estrogen receptor modulator
Uses
An antiestrogen and antineoplastic. Nonsteroidal antiestrogen structurally similar to tamoxifen
Uses
A chlorinated tamoxifen analogue, that induces apoptosis in some cells
Definition
ChEBI: Toremifene is a tertiary amine, an organochlorine compound and an aromatic ether. It has a role as an antineoplastic agent, an estrogen antagonist, an estrogen receptor modulator and a bone density conservation agent. It derives from a hydride of a stilbene.
Manufacturing Process
The reaction is performed under dry conditions. 2.1 g of lithium aluminum
hydride and 50 ml of dry tetrahydrofuran are placed in a flask. Then 13.2 g of
cinnamaldehyde in 50 ml of dry tetrahydrofuran are added while stirring and
keeping the temperature at 25°-35°C. The stirring is continued for another 30
min at room temperature. Then 26.9 g of 4-[2-(N,N-dimethylamino)-
ethoxy]benzophenone in 70 ml of dry tetrahydrofuran are added while
stirring. The temperature is kept at 35°-45°C during the addition. After
stirring for 2 h at 40°C the reaction mixture is poured into 150 ml of 25%
ammonium chloride solution, and aluminium hydroxide is precipitated and
filtered off. The filtrate is transferred to a separating funnel and the organic
layer is separated. The aqueous layer is once again extracted with 60 ml of
ethyl acetate. The organic layers are combined and dried over sodium sulfate.
The solvent is evaporated. The residue is recrystallized from toluene. The yield
is 27.5 g (68%) of 1,2-diphenyl-1-[4-[2-(N,N-dimethylamino)ethoxy]phenyl]-
butane-1,4-diol.
The reaction is performed under dry conditions. 40.5 g 1,2-diphenyl-1-[4-[2-
(N,N-dimethylamino)ethoxy]phenyl]butane-1,4-diol and 150 ml of acetic acid
anhydride are placed in a flask. The temperature is raised to 90°C, where it is
kept until the primary OH-group is completely acetylated. [4-Acetoxy-1,2-diphenyl-1-[4-[2-(N,N-dimethylamino)ethoxy]phenyl]butan-1-ol is obtained as
intermediate; melting point of the (RR, SS)-isomer pair is 97°-99°C. While
stirring the reaction mixture, 30 ml of acetyl chloride in 50 ml of acetic acid
anhydride are added at 90°C. The stirring is continued at this temperature for
2 h. The solvent is evaporated. Then 1 M sodium carbonate solution is added
in excess, after which the product is extracted in toluene. The solution is dried
over sodium sulfate, and the solvent is evaporated. The yield of the pure
isomer mixture (Z:E 2:1) of 4-acetoxy-1,2-diphenyl-1-[4-[2-(N,N_x0002_dimethylamino)ethoxy]-phenyl]-1-butene is quantitative.
The4-acetoxy-1,2-diphenyl-1-[4-[2-(N,N-dimethylamino)ethoxy]-phenyl]-1-
butene are dissolved in 94% ethanol, after which water and 20% sodium
hydroxide solution are added. The mixture is refluxed for 1 h. The solution is
neutralized with 2 M hydrochloric acid, after wich the ethanol is evaporated.
Water is added into the residue. The product is extracted in ethyl acetate, the
ethyl acetate solution is dried and the solvent is avaporated. The product is
recrystallized from a mixture of water and methanol. The yield of the pure
mixture of the isomers (Z:E 2:1) of 1,2-diphenyl-1-[4-[2-(N,Ndimethylamino)ethoxy]phenyl]-1-buten-4-ol, melting point 93°-100°C, is
quantitative.
Isolation of the (Z)-isomer as a free base: the mixture of the isomers (Z:E
2:1) of 1,2-diphenyl-1-[4-[2-(N,N-dimethylamino)ethoxy]phenyl]-1-buten-4-ol
is recrystallized from toluene, and 15.9 g (41%) of the (Z)-isomer is obtained,
melting point 110°-112°C.
The reaction is performed under dry conditions. 42.4 g of (Z)-1,2-diphenyl-1-
[4-[2-(N,N-dimethylamino)ethoxy]phenyl]-1-buten-4-ol are dissolved in 250
ml of chloroform. Then 23.8 g of thionyl chloride are added dropwise. The
mixture is refluxed 3 h. The solvent is evaporated, after which the product is
recrystallized from ethyl acetate. The yield of the hydrochloride salt of 4-
chloro-1,2-diphenyl-1-[4-[2-(N,N-dimethylamino)ethoxy]-phenyl]-1-butene
(Z) is 36.7 g (83%), melting point 194°-196°C.
The base can be liberated from the salt with 1 M sodium carbonate solution,
after which the base is extracted in toluene. The toluene solution is dried and
the solvent is evaporated. The free base, 4-chloro-1,2-diphenyl-1-[4-[2-(N,Ndimethylamino)ethoxy]-phenyl]-1-butene (Z), has melting point 108°-110°C
(from acetone).
In practice it is usually used as citrate salt (1:1).
brand name
Fareston
Therapeutic Function
Antiestrogen, Antineoplastic
Clinical Use
Hormone dependent metastatic breast cancer in post menopausal women
Drug interactions
Potentially hazardous interactions with other drugs
Anticoagulants: enhanced anticoagulant effect of
coumarins.
Cytotoxics: possible increased risk of ventricular
arrhythmias with vandetanib - avoid.
Metabolism
Toremifene is metabolised mainly by the cytochrome P450 isoenzyme CYP3A4. The main metabolite is N-demethyltoremifene and has similar anti-oestrogenic activity but weaker anti-tumour activity than toremifene. Toremifene is eliminated mainly as metabolites in the faeces.
Toremifene Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Toremifene manufacturers
- Product
- Toremifene 89778-26-7
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-08-11