4-Hydroxybenzophenone

Product Name: 4-Hydroxybenzophenone
CAS No.: 1137-42-4
Chemical Name: 4-Hydroxybenzophenone
Synonyms: POB;P-HYDROXYBENZOPHENONE;4-Hydroxydiphenylketone;NSC 1887;ENCL-001;benzoylphenol;Ospemifene INT;4-BENZOYLPHENOL;P-BENZOYLPHENOL;PARA-BENZOYLPHENOL
CBNumber: CB9237221
Molecular Formula: C13H10O2
Formula Weight: 198.22
MOL File: 1137-42-4.mol

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4-Hydroxybenzophenone Property

Melting point:: 132-135 °C(lit.)
Boiling point:: 260-262°C 42mm
Density: 1.1184 (rough estimate)
vapor pressure: 0Pa at 20℃
refractive index: 1.5954 (estimate)
Flash point:: 260-262°C/24mm
storage temp.: Store below +30°C.
solubility: Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
form: Powder
pka: 8.14±0.13(Predicted)
color: White to beige to brown
Water Solubility: Insoluble in water.
BRN: 777776
LogP: 1.6 at 35℃
CAS DataBase Reference: 1137-42-4(CAS DataBase Reference)
NIST Chemistry Reference: Methanone, (4-hydroxyphenyl)phenyl-(1137-42-4)
EPA Substance Registry System: Methanone, (4-hydroxyphenyl)phenyl- (1137-42-4)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36/37-24/25-36
WGK Germany: 2
RTECS: PC4959775
Hazard Note: Irritant
TSCA: Yes
HS Code: 29145000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H373May cause damage to organs through prolonged or repeated exposure

H412Harmful to aquatic life with long lasting effects

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P273Avoid release to the environment.

P314Get medical advice/attention if you feel unwell.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: H20202
Product name: 4-Hydroxybenzophenone
Purity: 98%
Packaging: 25g
Price: $67.8
Updated: 2024/03/01

Sigma-Aldrich

Product number: H20202
Product name: 4-Hydroxybenzophenone
Purity: 98%
Packaging: 100g
Price: $229
Updated: 2024/03/01

Sigma-Aldrich

Product number: 8.20661
Product name: 4-Hydroxybenzophenone
Purity: for synthesis
Packaging: 25g
Price: $50.7
Updated: 2024/03/01

Sigma-Aldrich

Product number: 8.20661
Product name: 4-Hydroxybenzophenone
Purity: for synthesis
Packaging: 100g
Price: $169
Updated: 2024/03/01

TCI Chemical

Product number: H0222
Product name: 4-Hydroxybenzophenone
Purity: >98.0%(GC)(T)
Packaging: 25g
Price: $45
Updated: 2024/03/01

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4-Hydroxybenzophenone Chemical Properties,Usage,Production

Chemical Properties

white to beige fine crystalline powder

Uses

4-Hydroxybenzophenone is used in the field of organic synthesis. It is used as pharmaceutical intermediate of clomifene citrate.

Uses

Metabolite of benzophenone.

Definition

ChEBI: 4-Hydroxybenzophenone is a member of benzophenones.

Preparation

Preparation by condensation of benzotrichloride,
? with phenol in the presence of aluminium chloride in carbon disulfide at 0° (90%) or in the presence of zinc oxide in a water bath;
? with p-bromophenol in 30% sodium hydroxide solution at 80–85° (81%). There is substitution of the bromine atom by the benzoyl group.

Synthesis Reference(s)

Journal of the American Chemical Society, 77, p. 4674, 1955 DOI: 10.1021/ja01622a074
The Journal of Organic Chemistry, 19, p. 978, 1954 DOI: 10.1021/jo01371a016
Tetrahedron Letters, 31, p. 3943, 1990 DOI: 10.1016/S0040-4039(00)97513-0

Flammability and Explosibility

Not classified

Purification Methods

Dissolve p-benzoylphenol in hot EtOH (charcoal), filter and cool. Alternatively crystallise it once from EtOH/H2O and twice from *benzene [Grunwald J Am Chem Soc 73 4934 1951, Dryland & Sheppard J Chem Soc Perkin Trans 1 125 1986]. [Beilstein 8 IV 1263.]

4-Hydroxybenzophenone Preparation Products And Raw materials

Raw materials

Aluminum chloride Phenyl benzoate

Preparation Products

Clomiphene Citrate 4-[2-(diethylamino)ethoxy]benzophenone alpha-[4-[2-(diethylamino)ethoxy]phenyl]-alpha-phenylphenethyl alcohol

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4-Hydroxybenzophenone Suppliers

Americas 1 Belgium 1 Canada 3 China 430 Europe 3 France 3 Germany 8 India 54 Japan 5 Poland 1 Slovakia 1 South Korea 4 Switzerland 3 Ukraine 2 United Kingdom 18 United States 39 Global 576

Shandong Vantage Specialty Chemicals Biotechnology Co., Ltd.

Tel: 133-96369453 18678026865
Fax: 0536-2101172
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Country: China
ProdList: 852
Advantage: 58

Weifang Mingran Chemical Co., Ltd.

Tel: 15066331899,0536-2082396,117761326 15063661899
Fax: 0536-2082397
Email: mingranchem@163.com
Country: China
ProdList: 430
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Weifang Weimeng Chemical Co., Ltd.

Tel: 0536-8790166 15105445095
Email: weimengchem@163.com
Country: China
ProdList: 459
Advantage: 58

Wuhan EnTai Technology Development Co,.Ltd

Tel: 86-27-82330560
Fax: 86-27-82330547
Email: 2536851935@qq.com
Country: China
ProdList: 348
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J & K SCIENTIFIC LTD.

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Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
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Tel: 4006608290; 18621169109
Fax: 86-21-61259102
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Country: China
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INTATRADE GmbH

Tel: +49 3493/605464
Fax: +49 3493/605470
Email: sales@intatrade.de
Country: Germany
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future industrial shanghai co., ltd

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ProdList: 1998
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Alfa Aesar

Tel: 400-6106006
Fax: 021-67582001/03/05
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TAIYUAN RHF CO.,LTD.

Tel: +86 351 7031519
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View Lastest Price from 4-Hydroxybenzophenone manufacturers

Ouhuang Engineering Materials (Hubei) Co., Ltd

Product: 4-Hydroxybenzophenone 1137-42-4
Price: US $50.00/kg
Min. Order: 1kg
Purity: 99.10%
Supply Ability: 5000kg
Release date: 2024-04-16

Hebei Yibangte Import and Export Co. , Ltd.

Product: 4-Hydroxybenzophenone 1137-42-4
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 50000kg
Release date: 2024-04-01

Wuhan Boyuan Import & Export Co., LTD

Product: 4-Hydroxybenzophenone 1137-42-4
Price: US $65.00-30.00/kg
Min. Order: 1kg
Purity: 99.5%
Supply Ability: 500tons
Release date: 2023-02-21

1137-42-4, 4-HydroxybenzophenoneRelated Search:

Acetaldehyde HYDROXYAPATITE TYPE I Diphenyl ether Phenyl salicylate Glycolic acid Benzophenone hydrazone Benzophenone PHENYL VALERATE Hydroxy silicone oil 4-Chlorobenzophenone 4-Methoxybenzophenone AKOS BB-9928 PHENYL RESIN 2,3,3',4'-TETRAMETHOXYBENZOPHENONE 3,4-Dihydroxybenzophenone 2,4-Dihydroxybenzophenone 2,6-DIHYDROXYANTHRAQUINONE 2,2'-Dihydroxy-4-methoxybenzophenone

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P-BENZOYLPHENOL

POB

P-HYDROXYBENZOPHENONE

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HYDROXYBENZOPHENONE-4

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PARA-BENZOYLPHENOL

(4-hydroxy)(phenyl)methanone

4-Hydroxybenzophenone, 98+%

4-Hydroxybenzophenone, 99+% 25GR

1-(4-Hydroxyphenyl)-1-phenylMethanone

NSC 1887

p-Hydroxybenzophenonfe

(4-Hydroxyphenyl)(phenyl)methanone, 4-Benzoylphenol

4-Hydroxybenzophenone≥ 99% (HPLC)

1-benzoyl-4-hydroxy-benzene

4-Hydroxybenzophenone, (4-Hydroxyphenyl)phenyl-methanone

ENCL-001

4-Hydroxybenzophene

4-Hydroxybenzophenone, 99%, for synthesis

4-Hydroxybenzophenone&gt

4-HYDROXYBENZOPHENONE FOR SYNTHESIS

4',2,4-trimethoxy benzophenone

Benzophenone 4-Hydroxybenzophenone organic photoinitiators

Ospemifene INT

4-hydroxy benzophenone (PHBP)

1137-42-4

1137-72-4

HOC6H4COC6H5

Building Blocks

Organic Building Blocks

Ketones

KETONE

Carbonyl Compounds

C7 to C8

Aromatics, Metabolites & Impurities

Organic Photoinitiators

Benzophenone

Polymerization Initiators

FINE Chemical & INTERMEDIATES

Aromatic Benzophenones & Derivatives (substituted)

Aromatics

Metabolites & Impurities

bc0001

1137-42-4