4-Hydroxybenzophenone
- Product Name
- 4-Hydroxybenzophenone
- CAS No.
- 1137-42-4
- Chemical Name
- 4-Hydroxybenzophenone
- Synonyms
- POB;P-HYDROXYBENZOPHENONE;4-Hydroxydiphenylketone;NSC 1887;ENCL-001;benzoylphenol;Ospemifene INT;4-BENZOYLPHENOL;P-BENZOYLPHENOL;PARA-BENZOYLPHENOL
- CBNumber
- CB9237221
- Molecular Formula
- C13H10O2
- Formula Weight
- 198.22
- MOL File
- 1137-42-4.mol
4-Hydroxybenzophenone Property
- Melting point:
- 132-135 °C(lit.)
- Boiling point:
- 260-262°C 42mm
- Density
- 1.1184 (rough estimate)
- vapor pressure
- 0Pa at 20℃
- refractive index
- 1.5954 (estimate)
- Flash point:
- 260-262°C/24mm
- storage temp.
- Store below +30°C.
- solubility
- Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
- form
- Powder
- pka
- 8.14±0.13(Predicted)
- color
- White to beige to brown
- Water Solubility
- Insoluble in water.
- BRN
- 777776
- LogP
- 1.6 at 35℃
- CAS DataBase Reference
- 1137-42-4(CAS DataBase Reference)
- NIST Chemistry Reference
- Methanone, (4-hydroxyphenyl)phenyl-(1137-42-4)
- EPA Substance Registry System
- Methanone, (4-hydroxyphenyl)phenyl- (1137-42-4)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36/37-24/25-36
- WGK Germany
- 2
- RTECS
- PC4959775
- Hazard Note
- Irritant
- TSCA
- Yes
- HS Code
- 29145000
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H373May cause damage to organs through prolonged or repeated exposure
H412Harmful to aquatic life with long lasting effects
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P273Avoid release to the environment.
P314Get medical advice/attention if you feel unwell.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- H20202
- Product name
- 4-Hydroxybenzophenone
- Purity
- 98%
- Packaging
- 25g
- Price
- $67.8
- Updated
- 2024/03/01
- Product number
- H20202
- Product name
- 4-Hydroxybenzophenone
- Purity
- 98%
- Packaging
- 100g
- Price
- $229
- Updated
- 2024/03/01
- Product number
- 8.20661
- Product name
- 4-Hydroxybenzophenone
- Purity
- for synthesis
- Packaging
- 25g
- Price
- $50.7
- Updated
- 2024/03/01
- Product number
- 8.20661
- Product name
- 4-Hydroxybenzophenone
- Purity
- for synthesis
- Packaging
- 100g
- Price
- $169
- Updated
- 2024/03/01
- Product number
- H0222
- Product name
- 4-Hydroxybenzophenone
- Purity
- >98.0%(GC)(T)
- Packaging
- 25g
- Price
- $45
- Updated
- 2024/03/01
4-Hydroxybenzophenone Chemical Properties,Usage,Production
Chemical Properties
white to beige fine crystalline powder
Uses
4-Hydroxybenzophenone is used in the field of organic synthesis. It is used as pharmaceutical intermediate of clomifene citrate.
Uses
Metabolite of benzophenone.
Definition
ChEBI: 4-Hydroxybenzophenone is a member of benzophenones.
Preparation
Preparation by condensation of benzotrichloride,
? with phenol in the presence of aluminium chloride in carbon disulfide at 0° (90%) or in the presence of zinc oxide in a water bath;
? with p-bromophenol in 30% sodium hydroxide solution at 80–85° (81%). There is substitution of the bromine atom by the benzoyl group.
Synthesis Reference(s)
Journal of the American Chemical Society, 77, p. 4674, 1955 DOI: 10.1021/ja01622a074
The Journal of Organic Chemistry, 19, p. 978, 1954 DOI: 10.1021/jo01371a016
Tetrahedron Letters, 31, p. 3943, 1990 DOI: 10.1016/S0040-4039(00)97513-0
Flammability and Explosibility
Not classified
Purification Methods
Dissolve p-benzoylphenol in hot EtOH (charcoal), filter and cool. Alternatively crystallise it once from EtOH/H2O and twice from *benzene [Grunwald J Am Chem Soc 73 4934 1951, Dryland & Sheppard J Chem Soc Perkin Trans 1 125 1986]. [Beilstein 8 IV 1263.]
4-Hydroxybenzophenone Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-Hydroxybenzophenone manufacturers
- Product
- 4-Hydroxybenzophenone 1137-42-4
- Price
- US $30.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 5000kg/week
- Release date
- 2024-04-24
- Product
- 4-Hydroxybenzophenone 1137-42-4
- Price
- US $99.00-66.00/kg
- Min. Order
- 0.0010000000474974513kg
- Purity
- 99%
- Supply Ability
- 5000
- Release date
- 2024-08-19
- Product
- 4-Hydroxybenzophenone 1137-42-4
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2024-10-25